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  4. Recombinant Human Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1)

Recombinant Human Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1)

  • 中文名稱：
    Recombinant Human Cyclin-dependent kinase 2-associated protein 1(CDK2AP1)
  • 貨號(hào)：
    CSB-EP005062HU
  • 規(guī)格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    CDK2AP1
  • Uniprot No.：
  • 別名：
    CDK2 A1; CDK2 associated protein 1; CDK2-associated protein 1; CDK2AP1; CDKA1; CDKA1_HUMAN; Cyclin dependent kinase 2 associated protein 1; Cyclin-dependent kinase 2-associated protein 1; Deleted in oral cancer 1; DOC 1; DOC 1 related protein; DOC 1R; DOC-1; DOC1; DOC1R; DORC1; p12DOC 1; Putative oral cancer suppressor; ST19
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full Length
  • 來(lái)源：
    E.coli
  • 分子量：
    39.4kDa
  • 表達(dá)區(qū)域：
    1-115aa
  • 氨基酸序列
    MSYKPNLAAHMPAAALNAAGSVHSPSTSMATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal GST-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    specific inhibitor of the cell-cycle kinase CDK2.
  • 基因功能參考文獻(xiàn)：
    1. A compelling relationship exists between high CDK2AP1 mRNA expression and lower TNM classification of breast cancer, which is consistent with CDK2AP1 having a tumour-suppressive function. PMID: 30343278
    2. Knockdown of CDK2AP1 in hESCs results in increased p53 and enhances differentiation and favors it over a self-renewal fate. PMID: 29734353
    3. DOC1 re-expression in oral cancer cells causes a reversal of EMT. DOC1 promotes NURD binding to a subset of target loci. PMID: 28683324
    4. The simultaneous overexpression of p12CDK2-AP1 and CD82 significantly suppressed the in vivo tumor growth. PMID: 27349208
    5. knockdown of CDK2AP1 in primary human fibroblasts reduced proliferation and induced premature senescence, with the observed phenotype being p53 dependent PMID: 25785833
    6. In summary, p12CDK2AP1 expression in myxofibrosarcoma cells induces G0/G1 arrest and mitochondria dependent proapoptotic activity and down-regulation of p12CDK2AP1 by shRNAi results in up-regulation of the CDK2 transcript and protein. PMID: 24889487
    7. Study reports that knockdown of CDK2AP1 by RNAi in glioma cells could effectively inhibit cell proliferation by inducing cell cycle arrest and apoptosis PMID: 24620959
    8. CDK2AP1 plays an important role in modulating the growth and tumorigenesis of lung cancer cells. PMID: 23404055
    9. Low CDK2AP1 expression is common and associated with adverse prognosis in nasopharyngeal carcinoma. PMID: 22791769
    10. Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region PMID: 22427660
    11. exerts its effect on stem cell maintenance/differentiation through epigenetic regulation [review] PMID: 21865592
    12. In comparison with the healthy gingiva, the expression of Doc-1 was decreased, whereas the expression of S100A7 was upregulated in all oral lesions. PMID: 21740085
    13. P12(CDK2AP1) is downregulated by miR-21 PMID: 21328460
    14. Missing down-regulation of the tumor-suppressor gene DOC-1, might exert protective effects and counteract malignant transformation of benign, proliferating lesions of the oral cavity. PMID: 21187770
    15. Data support the role of cdk2ap1 as a tumor suppressor gene that can regulate squamous cell carcinoma growth in a cell autonomous manner through decreases in invasiveness and a non-cell autonomous manner through decreases in angiogenesis phenotypes. PMID: 20541561
    16. The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation. PMID: 20727496
    17. Results indicate that DOC-1 is a bona fide subunit of the Mi-2/NuRD chromatin remodeling complex. PMID: 20523938
    18. CDK2AP1 is a novel multiple sclerosis susceptibility loci, and it's risk allele correlates with diminished RNA expression of the cell cycle regulator CDK2AP1 PMID: 20555355
    19. Data show low or moderate methylation was found in seven selected genes BAD, BBC3, CAV1, CDK2AP1, NPM1, PRKCDBP and THEM4. PMID: 19679565
    20. DOC1 has a differential expression in microsatellite-unstable human colorectal neoplasms. PMID: 13679870
    21. plays a role in TGF-beta1-mediated growth suppression by modulating CDK2 activities and pRB phosphorylation PMID: 14744761
    22. p12CDK2-AP1 forms nuclear homodimers in contact inhibited normal diploid cells and dimerization of p12 is a necessary process for the growth inhibition effect by p12 PMID: 15840587
    23. Resistance to TGF-beta 1-induced growth suppression is due to the disruption of its signaling pathway as a consequence of reduced or lost p12(CDK2-AP1). PMID: 17217620
    24. the del T poly (T) 8 observed in the 3'-UTR of the CDK2-AP1 gene in human microsatellite unstable colorectal cancer is functionally significant and results in decreased CDK2-AP1 expression PMID: 17689689
    25. expression negatively associated with a more advanced depth of tumor invasion and stage in gastric carcinoma PMID: 19279387
    26. p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma. PMID: 19513502
    27. The expression of cdk2ap1 correlated with a reduction in cellular growth, irrespective of inhibition or stimulation of androgen receptor (AR) signaling pathways PMID: 19585490

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  • 蛋白家族：
    CDK2AP family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14002

    OMIM: 602198

    KEGG: hsa:8099

    STRING: 9606.ENSP00000261692

    UniGene: Hs.433201