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  4. Recombinant Human Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (COX4I2), partial

Recombinant Human Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (COX4I2), partial

  • 中文名稱：
    Recombinant Human Cytochrome c oxidase subunit 4 isoform 2, mitochondrial(COX4I2) ,partial,Yeast
  • 貨號：
    CSB-YP856966HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Cytochrome c oxidase subunit 4 isoform 2, mitochondrial(COX4I2) ,partial,Yeast
  • 貨號：
    CSB-EP856966HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Cytochrome c oxidase subunit 4 isoform 2, mitochondrial(COX4I2) ,partial,Yeast
  • 貨號：
    CSB-EP856966HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Cytochrome c oxidase subunit 4 isoform 2, mitochondrial(COX4I2) ,partial,Yeast
  • 貨號：
    CSB-BP856966HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Cytochrome c oxidase subunit 4 isoform 2, mitochondrial(COX4I2) ,partial,Yeast
  • 貨號：
    CSB-MP856966HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    COX IV-2; COX4 2; COX4; COX42_HUMAN; COX4B; Cox4i2; COX4L2; COXIV 2; Cytochrome c oxidase subunit 4 isoform 2; Cytochrome c oxidase subunit 4 isoform 2 mitochondrial [Precursor]; cytochrome c oxidase subunit IV isoform 2 (lung); Cytochrome c oxidase subunit IV isoform 2; dJ857M17.2; mitochondrial; RP23 106A3.3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 表達區(qū)域：
    -
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunbit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能參考文獻：
    1. Identification of three transcription factors that bind a conserved responsive element of the COX4I2 gene, namely recombination signal sequence-binding protein Jkappa (RBPJ), coiled-coil-helix-coiled-coil-helix domain 2 (CHCHD2) and CXXC finger protein 5 (CXXC5). PMID: 23303788
    2. Mutation analysis of COX4I2 is warranted in patients with malabsorption due to exocrine pancreatic insufficiency and in patients with dyserythropoeitic anemia. PMID: 19268275
    3. COX4I2 is regulated by a novel oxygen sensitive promoter element (5'-GGACGTTCCCACG-3') conserved in mammals. Gene activity is maximal at 4% oxygen. Lung cytochrome c oxidase (COX) is 2.5 fold more active compared to liver COX, which lacks COX4I2. PMID: 17937768
    4. COX4I2 is expressed in the highly oxygenated lung tissue. It is found in all cell types of the lung. PMID: 11311561
  • 相關(guān)疾病：
    Exocrine pancreatic insufficiency dyserythropoietic anemia and calvarial hyperostosis (EPIDACH)
  • 亞細胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    Cytochrome c oxidase IV family
  • 組織特異性：
    Highly expressed in lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16232

    OMIM: 607976

    KEGG: hsa:84701

    STRING: 9606.ENSP00000365243

    UniGene: Hs.277101