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  4. Recombinant Human E3 ubiquitin-protein ligase RBBP6 (RBBP6), partial

Recombinant Human E3 ubiquitin-protein ligase RBBP6 (RBBP6), partial

  • 中文名稱：
    人RBBP6重組蛋白
  • 貨號：
    CSB-YP768776HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RBBP6重組蛋白
  • 貨號：
    CSB-EP768776HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RBBP6重組蛋白
  • 貨號：
    CSB-EP768776HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RBBP6重組蛋白
  • 貨號：
    CSB-BP768776HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RBBP6重組蛋白
  • 貨號：
    CSB-MP768776HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RBBP6
  • Uniprot No.：
  • 別名：
    DKFZp686P0638; DKFZp761B2423; E3 ubiquitin-protein ligase RBBP6; MY038; P2P R; P2PR; p53 associated cellular protein of testis; p53-associated cellular protein of testis; p53-associated cellular protein, testis-derived; PACT; Proliferation potential related protein; Proliferation potential-related protein; Protein P2P R; Protein P2P-R; Protein P2PR; Protein RBQ 1; Protein RBQ1; RB binding protein 6, ubiquitin ligase; RB binding Q protein 1; RBBP 6; Rbbp6; RBBP6_HUMAN; RBQ 1; RBQ-1; RBQ1; Retinoblastoma binding protein 6 isoform 3; Retinoblastoma binding Q protein 1; Retinoblastoma-binding protein 6; Retinoblastoma-binding Q protein 1; SNAMA; SNAMA, Drosophila, homolog of
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication.; (Microbial infection) restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription.
  • 基因功能參考文獻：
    1. RBBP6 might potentiate cervical carcinoma cell viability. PMID: 29501043
    2. Results from a study on gene expression variability markers in early-stage human embryos shows that RBBP6 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    3. RBBP6 overexpression could resist colorectal cancer cells against radiation. PMID: 29369481
    4. These results suggest that the RBBP6-3 isoform may be involved in promoting apoptosis in cancerous cells. PMID: 26905308
    5. RBBP6 is a candidate gene for myeloproliferative neoplasms (MPNs) susceptibility in a subset of pedigrees with familial MPN. PMID: 26574608
    6. High expression levels of RBBP6 and high apoptosis levels were found in HIV-associated nephropathy (HIVAN) cases. This direct association between RBBP6 expression and apoptosis levels suggests that RBBP6 play a role in HIVAN pathogenesis. PMID: 25910411
    7. gene silencing sensitises breast cancer cells to staurosporine and camptothecin-induced cell death PMID: 24703106
    8. RBBP6 prevents DNA damage by destabilizing the transcriptional repressor ZBTB38. PMID: 24726359
    9. RBBP6 gene variants are associated with glioma and contribute to glioma susceptibility PMID: 25127414
    10. implicate RBBP6 and iso3 as novel regulators of 3' processing, especially of RNAs with AU-rich 3' UTRs. PMID: 25319826
    11. these findings suggest that RBBP6 isoform 3 is a cell cycle regulator and may be deregulated in carcinogenesis PMID: 22139301
    12. AGO2, PACT and TRBP are required for the efficient functioning of Dicer in cells PMID: 22163034
    13. Taken together with the structural similarities to U-box-containing proteins, our data suggest that RBBP6 plays a role in chaperone-mediated ubiquitination and possibly in protein quality control. PMID: 22130672
    14. RBBP6 may be involved in the degradation of p53, thereby enhancing cell proliferation and inhibiting apoptosis in lung cancer. PMID: 21676486
    15. P2P-R expression may be translationally regulated by PUM2 and that P2P-R may modulate translation by influencing ribosomal protein gene expression PMID: 15617101
    16. RBBP6 has a role in mRNA processing and ubiquitin-like pathways PMID: 16396680
    17. The authors showed that RBBP6 and its isolated RING finger domain were able to ubiquitinate YB-1, resulting in its degradation in the proteosome. As a result, RBBP6 was able to suppress the levels of YB-1 in vivo and reduce its transactivational ability. PMID: 18851979

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  • 亞細胞定位：
    Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.
  • 組織特異性：
    Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9889

    OMIM: 600938

    KEGG: hsa:5930

    STRING: 9606.ENSP00000317872

    UniGene: Hs.188553