Recombinant Human Epoxide hydrolase 1 (EPHX1), partial
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中文名稱:人EPHX1重組蛋白
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貨號(hào):CSB-YP007734HU
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規(guī)格:
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來(lái)源:Yeast
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其他:
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中文名稱:人EPHX1重組蛋白
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貨號(hào):CSB-EP007734HU-B
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規(guī)格:
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來(lái)源:E.coli
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共軛:Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他:
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中文名稱:人EPHX1重組蛋白
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貨號(hào):CSB-BP007734HU
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規(guī)格:
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來(lái)源:Baculovirus
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其他:
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中文名稱:人EPHX1重組蛋白
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貨號(hào):CSB-MP007734HU
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規(guī)格:
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來(lái)源:Mammalian cell
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其他:
產(chǎn)品詳情
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純度:>85% (SDS-PAGE)
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基因名:EPHX1
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Uniprot No.:
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別名:EPHX 1; EPHX; Ephx1; EPOX; Epoxide hydratase; Epoxide hydrolase 1; Epoxide hydrolase 1 microsomal (xenobiotic); Epoxide hydroxylase 1; Epoxide hydroxylase 1 microsomal (xenobiotic); HYEP_HUMAN; HYL1; MEH; Microsomal epoxide hydrolase
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種屬:Homo sapiens (Human)
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蛋白長(zhǎng)度:Partial
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蛋白標(biāo)簽:Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式:Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復(fù)溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲(chǔ)存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項(xiàng):Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet :Please contact us to get it.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol.
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基因功能參考文獻(xiàn):
- The substrate specificity of microsomal epoxide hydrolase should therefore be expanded to include not only epoxides but also the oxetanyl ring system present in AZD1979. PMID: 27256986
- EPHX1 variants were significantly associated with higher metabolic ratio of carbamazepine PMID: 27276192
- Single nucleotide polymorphisms in EPHX1, GSTP1, SERPINE2, and TGFB1 contributing to the quantitative traits of chronic obstructive pulmonary disease in Chinese Han population. PMID: 27193053
- This study showed that polymorphisms of EPHX1 and VKORC1L1 could be determinants of stable warfarin doses. PMID: 29054760
- The Tyr113His T/C variant of rs1051740 and very slow phenotype alters EPHX1, miR-26b-5p and miR-1207-5p expression, and contributes towards low blood iron levels and low birthweights. PMID: 28789952
- Structural characterization of human microsomal epoxide hydrolase by combined homology modeling, molecular dynamics simulations, and molecular docking calculations has been reported. PMID: 28120429
- Y113H polymorphism in EPHX1 gene contributed to increased susceptibility to COPD in the Kazakhstan population. PMID: 28464990
- EPHX1 polymorphisms were not associated with sporadic colorectal neoplasms. PMID: 28018104
- This study demonstrated that two SNPs might play roles in the process of nicotine metabolism and abstinence, rs1051740 being more important; and EPHX SNPs (rs1051740 and rs2234922) are associated with the effectiveness of Nicotine Replacement Therapy . PMID: 27783326
- No association was found between EPHX1 and COPD; however, a minor effect of EPHX1 on COPD risk was not completely excluded. PMID: 27173271
- The SCN1A IVS5-91G>A SNP is associated with susceptibility to epilepsy. SNPs in EPHX1 gene are influencing CBZ metabolism and disposition PMID: 26555147
- In conclusion, GSTs, EPHX1, and XPD are potential genetic factors for arsenic-induced skin cancers. The roles of these genes for arsenic-induced skin carcinogenesis need to be further evaluated. PMID: 26295053
- the EPHX1 Tyr113His polymorphism may be a risk factor for lung cancer in Asians, whereas it may be a decreased risk factor among Caucasians. However, this polymorphism was not found to be associated with breast cancer. PMID: 25222243
- To be poly(ADP-ribose)polymerase-1 (PARP-1) bound to the EPHX1 proximal promoter. PMID: 25992604
- Polymorphism in the EPHX1 gene may have a significant role in differential responses to treatment with N-acetylcysteine in patients with COPD. PMID: 25999707
- This review and meta-analysis suggests that EPHX1 Tyr113His polymorphism may be a risk factor for Head and Neck Cancer, while the EPHX1 His139Arg polymorphism has no association with Head and Neck Cancer risk. PMID: 25923690
- Studies suggest that the presence of microsomal epoxide hydrolase 1 (EPHX1) single nucleotide polymorphisms (SNPs) may significantly affect the risk of lung, upper aerodigestive tract, breast, bladder, and ovarian carcinomas. PMID: 26216302
- the genetic associations exist between mEH polymorphisms and lung cancer susceptibility in Asian populations PMID: 25312477
- These results demonstrate that 2-AG is an endogenous substrate for EPHX1, a potential role of EPHX1 in the endocannabinoid signaling and a new AA biosynthetic pathway. PMID: 24958911
- EPHX1 rs2292566 polymorphism may affect the maintenance dose of warfarin in Caucasians. PMID: 25629049
- His/His genotype of EPHX1 Tyr113His polymorphism is a risk factor for developing caner for Asian and mixed population, while no evidence was found for the association between the EPHX1 His139Arg polymorphism and increased cancer risk. PMID: 25261893
- EPHX1 Tyr113His and His139Arg polymorphism are not associated with esophageal cancer risk. PMID: 25714851
- This meta-analysis suggests that EPHX1 Tyr113His polymorphism contributes to HCC risk. PMID: 26065263
- No clear effect is evident for EPHX1 polymorphisms for different radon concentrations on the risk of lung cancer. PMID: 24852519
- Review/Meta-analysis: suggest p.Tyr113His and p.His139Arg polymorphisms in EPHX1 may not be associated with esophageal cancer development. PMID: 24803829
- This study provides direct evidence that methylation plays an important role in PCOS and demonstrates a novel role for EPHX1 in female reproduction. PMID: 24505354
- Meta-analysis showed that the Tyr113His polymorphism was a stronger power trend towards risk for esophageal cancer using a recessive model PMID: 24615030
- The association of EPHX1 polymorphism with the HELLP syndrome and eclampsia may hint to EPHX being a further key player in the pathogenesis of preeclampsia. PMID: 24013430
- Results suggest that Exons 3 and 4 polymorphisms of the mEH gene may contribute to lung cancer susceptibility through disturbed antioxidant balance. PMID: 23928928
- The C allele and C-G diplotype of EPHX1 may play important roles in increasing the risk of CBZ-SJS/toxic epidermal necrolysis development of epilepsy in Chinese Han patients. PMID: 24861996
- Chinese epilepsy patients with variant EPHX1 c.416A>G genotype have higher plasma carbamazepine concentrations compared to those with the wild type genotype. PMID: 24125961
- No evidence of an association of EPHX1 Tyr113His or His139Arg polymorphisms with risk for development of esophageal cancer. [Meta-analysis] PMID: 24222229
- EPHX1 genetic polymorphisms were not associated with the risk of HCC. PMID: 23955801
- The study showed that microsomal epoxide hydrolase exon 3 113Tyr-139Arg was associated with gastric cancer in presence of H. pylori, though in its absence, it appeared to be protective. PMID: 23580125
- Sp1 and Sp3 are functionally involved as transcriptional integrators regulating the basal expression of the derived microsomal epoxide hydrolase E1b variant transcript. PMID: 24315822
- Genotype frequencies for EPHX1 polymorphisms did not show any correlation with lymphoma. PMID: 23651475
- This meta-analysis suggests that EPHX1 His139Arg polymorphism is associated with decreased risk of esophageal cancer in Caucasians. PMID: 23681797
- There is substantial evidence that mEH polymorphisms interact synergistically with other genes and the environment to modulate risk of HCC PMID: 23451147
- findings suggest that benzene exposure may be associated with hypermethylation in ERCC3, and that genetic variants in EPHX1 may play an important role in epigenetic changes and hematotoxicity among benzene-exposed workers PMID: 23797950
- This is the first report that examined HIF1A polymorphisms in chronic obstructive pulmonary disease and demonstrated a possible role of HIF-1alpha in COPD, as well as GSTP1 and EPHX1. PMID: 21651746
- EPHX1 transcript, termed E1-b', drives EPHX1 expression primarily in the ovary. PMID: 23564882
- EPHX1 gene polymorphisms and haplotypes are associated with an increased risk for alcoholism in the Kota Indian population PMID: 22257321
- minor Tyr113 allele of mEPHX1 polymorphism had a higher risk of type 2 diabetes mellitus PMID: 22555758
- Microsomal epoxide hydrolase 1 T113C polymorphism is associated with lung cancer. PMID: 23378225
- the maternal EPHX1 rs1051740 genotype (RR = 3.26, P = .01) was associated with medulloblastoma risk. PMID: 22994552
- Meta-analyses of available data supported the concept of EPHX1 A139G polymorphism as a genetic susceptibility factor for lung cancer PMID: 23055191
- EPHX1 gene polymorphisms and haplotypes were not involved in the susceptibility to oral cancer in South Indian subjects. PMID: 21453055
- EPHX1 Tyr113His polymorphism may be not associated with CRC development PMID: 22928041
- Study analyzed the association between four SNPs in the EPHX1 and EPHX2 and the risk of oligozoospermia and asthenospermia; rs1051740, rs2234922 and rs751141 were not associated with oligozoospermia and asthenospermia and rs1042064 was a protective factor in idiopathic male infertility. PMID: 22986331
- microsomal epoxide hydrolase polymorphism is associated with chromosomal instability of 1,3-butadiene exposed workers. PMID: 22156006
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相關(guān)疾?。?/div>Familial hypercholanemia (FHCA)亞細(xì)胞定位:Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.蛋白家族:Peptidase S33 family組織特異性:Found in liver.數(shù)據(jù)庫(kù)鏈接:
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