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  4. Recombinant Human F-box only protein 11 (FBXO11), partial

Recombinant Human F-box only protein 11 (FBXO11), partial

  • 中文名稱：
    人FBXO11重組蛋白
  • 貨號：
    CSB-YP774829HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FBXO11重組蛋白
  • 貨號：
    CSB-EP774829HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FBXO11重組蛋白
  • 貨號：
    CSB-EP774829HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FBXO11重組蛋白
  • 貨號：
    CSB-BP774829HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FBXO11重組蛋白
  • 貨號：
    CSB-MP774829HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FBXO11
  • Uniprot No.：
  • 別名：
    F box only protein 11; F box protein 11; F-box only protein 11; FBX11; FBX11_HUMAN; Fbxo11; PRMT9; Protein arginine N methyltransferase 9; Ubiquitin protein ligase E3 component n recognin 6; UBR6; UG063H01; VIT 1; VIT-1; VIT1; Vitiligo associated protein 1; Vitiligo associated protein VIT 1 ; Vitiligo-associated protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
  • 基因功能參考文獻：
    1. High expression of FBXO11 predicted a poor survival of hepatocellular carcinoma patients. PMID: 29518611
    2. Understanding of the functions of FBXO11. PMID: 29278851
    3. FBXO11 is a direct target of miR-621 in breast cancer cells. PMID: 25867061
    4. UBR3/6 regulate cardiomyocyte Nav 1.5 channel protein levels via the ubiquitin-proteasome pathway. PMID: 26059563
    5. siRNA-mediated knockdown of FBXO11 facilitated HIF-1alpha expression in various cancer cells and HIF-1alpha-driven gene expressions, but the FBXO10 knockdown did not. PMID: 26187670
    6. Our results identify FBXO11 as a novel miR-21 target gene, and demonstrate that the oncogenic miRNA miR-21 decreases the expression of FBXO11, which normally acts as a tumor suppressor, and thereby promotes tumorigenesis. PMID: 25589783
    7. The PKD1-FBXO11-SNAIL axis is a mechanism of posttranslational regulation of epithelial-mesenchymal transition and cancer metastasis. PMID: 25203322
    8. TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2. PMID: 23892434
    9. The functional interaction between FBXO11 and CDT2 is evolutionary conserved from worms to humans and plays an important role in regulating the timing of cell-cycle exit. PMID: 23478441
    10. Migration of epithelial cells is stimulated by CRL1(FBXO11)-mediated downregulation of Cdt2 and the consequent stabilization of Set8. PMID: 23478445
    11. A molecular mechanism controlling BCL6 stability--mutations and deletions in FBXO11 contribute to lymphomagenesis through BCL6 stabilization PMID: 22113614
    12. these data provide strong evidence for FBXO11 as a susceptibility gene for severe OM. PMID: 21293382
    13. Results support the notion that FBXO11 plays an important role in regulating proliferation and apoptosis of melanocytes, and functional export of tyrosinase from ER in vitiligo melanocytes. PMID: 20514423
    14. FBXO11 has a lower expression in skin lesion tissues than in normal tissues from vitiligo patients. PMID: 20646433
    15. A type II protein arginine methyltransferase that forms asymmetric dimethylarginine modifications in proteins. PMID: 16487488
    16. The FBXO11 gene is the human homologue of the gene mutated in the novel deaf mouse mutant jeff (Jf), a single gene model of otitis media. FBXO11 gene for association with chronic otitis media with effusion. PMID: 16847180
    17. FBXO11 promotes the Neddylation (NEDD8) of p53 and inhibits its transcriptional activity PMID: 17098746

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  • 相關(guān)疾?。?/div>
    Defects in FBXO11 may be a cause of diffuse large B-cell lymphoma by allowing the accumulation of BCL6, an oncoprotein that has a critical role in lymphomas.
  • 亞細胞定位：
    Nucleus. Chromosome.
  • 組織特異性：
    Isoform 5 is expressed in keratinocytes, fibroblasts and melanocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13590

    OMIM: 607871

    KEGG: hsa:80204

    STRING: 9606.ENSP00000384823

    UniGene: Hs.352677