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  4. Recombinant Human Fibrinogen gamma chain (FGG)

Recombinant Human Fibrinogen gamma chain (FGG)

  • 中文名稱：
    人FGG重組蛋白
  • 貨號：
    CSB-YP008651HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FGG重組蛋白
  • 貨號：
    CSB-EP008651HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FGG重組蛋白
  • 貨號：
    CSB-BP008651HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FGG重組蛋白
  • 貨號：
    CSB-MP008651HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    FGG; FIBG_HUMAN; Fibrinogen gamma chain; Fibrinogen gamma polypeptide; fibrinogen gamma-b chain
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    27-453
  • 氨基酸序列
    YVAT RDNCCILDER FGSYCPTTCG IADFLSTYQT KVDKDLQSLE DILHQVENKT SEVKQLIKAI QLTYNPDESS KPNMIDAATL KSRKMLEEIM KYEASILTHD SSIRYLQEIY NSNNQKIVNL KEKVAQLEAQ CQEPCKDTVQ IHDITGKDCQ DIANKGAKQS GLYFIKPLKA NQQFLVYCEI DGSGNGWTVF QKRLDGSVDF KKNWIQYKEG FGHLSPTGTT EFWLGNEKIH LISTQSAIPY ALRVELEDWN GRTSTADYAM FKVGPEADKY RLTYAYFAGG DAGDAFDGFD FGDDPSDKFF TSHNGMQFST WDNDNDKFEG NCAEQDGSGW WMNKCHAGHL NGVYYQGGTY SKASTPNGYD NGIIWATWKT RWYSMKKTTM KIIPFNRLTI GEGQQHHLGG AKQVRPEHPA ETEYDSLYPE DDL
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
  • 基因功能參考文獻(xiàn)：
    1. These data suggest that single nucleotide polymorphisms ABO rs8176719 and FGG rs2066865 may contribute individually to the venous thromboembolism susceptibility in the Portuguese population. PMID: 29995659
    2. DNA sequencing revealed a novel heterozygous CCTTTGATG deletion in the exon 8 of FGG, leading to the deletion of Ala289, Phe290, and Asp291 in fibrinogen gamma-chain PMID: 29748775
    3. The simultaneous retention of fibrinogen and APOB-lipoproteins in FSD can be detected in routinely stained histological sections. The analysis of protein structures unraveled the pathomorphogenesis of this unexpected phenomenon. Fibrinogen gamma chain mutations provoke conformational changes in the region of the globular domain involved in the "end-to-end" interaction, thus impairing the D-dimer formation PMID: 29244742
    4. The D356V (D330V) mutation located in the C-terminus was predicted to be highly deleterious and to affect the function of the protein. The obtained computational results suggest that the substitution of the neutral amino acid valine for the acidic amino acid aspartic acid at position 356 results in an unwound conformation within 50 ns, which might contribute to defective polymerization. PMID: 27677677
    5. Fibrinogen gamma acts as thrombomodulin II. (Review) PMID: 27784620
    6. Gene analysis of the fibrinogen phenotype reveals the importance of polygenic co-regulation. PMID: 27771416
    7. Fibrinogen gamma chain and complement factor H were found to be bound as a protein complex in the plasma of a patient with advanced ovarian cancer PMID: 28551622
    8. Our data indicate that the amplitude and maximal velocity of coagulation curves from plasma samples from FGG p.Arg301(275)Cys dysfibrinogenemic patients were comparable to those from plasma samples with fibrinogen in the normal range, whereas the amplitude of coagulation curves from patients with acquired low fibrinogen levels was lower PMID: 28318107
    9. These results suggest that among the elderly, gamma ' fibrinogen does not add much to cardiovascular disease prediction beyond traditional risk factors and total fibrinogen level. PMID: 27180117
    10. rs2066865 polymorphism has an important role in the development of venous thromboembolism in the white race PMID: 28353616
    11. Gene polymorphisms FGG C>T (rs6536024) were not associated with height, weight, or morbid obesity among European subjects. PMID: 27999448
    12. A lower plasma concentration of gamma' gamma fibrinogen in healthy adults does not appear to increase venous thromboembolism risk. PMID: 26916295
    13. In addition to the reduction of FG concentration expected by the nature of the mutation also a functional defect (hypodysfibrinogenemia) was found. Moreover this mutation seems to increase the risk of thrombosis warranting long term anticoagulation possibly in a combination with antiplatelet drugs. PMID: 26540127
    14. congenital dysfibrinogenemia with a novel mutation in fibrinogen gamma chain (gamma322 Phe-->Ile, Fibrinogen Beijing) and haemophilia B in a family PMID: 25982359
    15. 5877G>A mutation in the exon 8 of the FGG gene is underlies the pathogenesis of congenital dysfibrinogenemia in a Chinese family. PMID: 27060305
    16. Case Reports: clustering of mutations causing fibrinogen storage disease in the fibrinogen gamma chain between residues 284 and 375. PMID: 26039544
    17. Data indicate that mutations of the fibrinogen (Fg) gene seem to aggregate to the D region of fibrinogen gamma chain (FGG) PMID: 26663050
    18. Letter/Case Report: FGG 320Asp-Glu substitution that displayed both a quantitative and functional defect and presented as hypodysfibrinogenaemia. PMID: 25042726
    19. Low FI levels are strongly associated with rare CFI variants and age-related macular degeneration. PMID: 25788521
    20. Report role of gamma'-fibrinogen in control of hemostatic clot growth in the venous circulation. PMID: 25614284
    21. Letter/Case Report: FGG 339CysSer mutation causes only hypofibrinogenaemia. Accompanying functionality change is due to increased sialylation and inheritance of the B448Lys allele. PMID: 25588350
    22. Suggest gamma' fibrinogen concentrations reflect general inflammation that accompanies and may contribute to atherosclerotic CVD, instead of gamma' fibrinogen being a causal risk factor. PMID: 26494231
    23. This study shows that homocysteine influences blood clot properties alone and in combination with total fibrinogen but not with fibrinogen gamma' isoform in Africans. PMID: 25688462
    24. investigated molecular basis of dysfibrinogenaemia in a Chinese pedigree; sequencing results of proband revealed a novel heterozygous IVS9+1delG mutation of FGG gene; same results were found in her mother sister and daughter; concluded the mutation is responsible for the proband's dysfibrinogenaemia PMID: 25551304
    25. Data indicate that leptin receptor gene (LEPR) single-nucleotide polymorphisms (SNPs) rs4291477 significantly associated with serum fibrinogen. PMID: 25296580
    26. A novel mutation in FGG gene is associated with congenital hypofibrinogenemia. PMID: 26037343
    27. Final clot structure may contribute to increased cardiovascular disease (CVD) risk in vivo through associations with other CVD risk factors independent from total or gamma' fibrinogen concentration. PMID: 25213709
    28. Novel fibrinogen mutations (gammaTrp208Leu and gammaLys232Thr) leading to congenital hypofibrinogenemia in two unrelated Chinese families have been described. PMID: 24914742
    29. Exploratory multilocus polygenic analyses with p <0.05 showed an association of optimism with SNPs in MAOA, IL10, and FGG genes, and an association of resilience with a SNP in MAOA. PMID: 24791650
    30. While the gamma Ser313Gly mutation manifested as dysfibrinogenemia with a thrombotic background, the gamma Phe204Val mutation manifested as hypofibrinogenemia without clinical symptoms. PMID: 25074738
    31. observed increased APC resistance in carriers of fibrinogen gamma gene (FGG) haplotype 2, which is associated with reduced levels of the alternatively spliced fibrinogen gamma' chain. We then studied the effects of fibrinogen and its gamma' chain on APC resistance. PMID: 24951429
    32. novel causitive mutation is identified in a New Zealand family with hypofibrinogenaemia PMID: 24352576
    33. elevated levels of gammaA/gammaA fibrinogen promote arterial thrombosis in vivo, whereas gammaA/gamma' does not PMID: 24916154
    34. Reduced plasminogen binding and delayed activation render gamma'-fibrin more resistant to lysis than gammaA-fibrin. PMID: 25128532
    35. report of 2 hypofibrinogenemias, Shizuoka III and Kanazawa II, caused by heterozygous nonsense mutation at the fibrinogen gamma-chain, gamma23X and gamma376X, respectively; analysis demonstrated the transcribed aberrant mRNAs from both gamma23X and gamma376X genes are degraded by nonsense-mediated mRNA decay and not translated to the truncated polypeptide PMID: 24011387
    36. A heterozygous point mutation located in exon 3 of the FGG gene c.140C>T (p.Thr21Ile)was found in a patient and her mother, both of whom had hypofibrinogenemia. PMID: 24556703
    37. A novel FGG mutation is associated with hypofibrinogenemia. PMID: 23492915
    38. A decreased number of factor XIIIa+ cells is found in the lower dermis following pulsed dye laser treatment. PMID: 23645504
    39. Results indicate that the alphaC domain of fibrinogen harbors a Zn(2+)-dependent heparin binding site. PMID: 23990470
    40. Data indicate that the adhesive alpha-granule proteins fibrinogen and thrombospondin are concentrated in a fibrin polymerization-dependent "cap" on phosphatidylserine-expressing platelets that promotes their incorporation into thrombi. PMID: 23995838
    41. Letter/Case Report: deep vein thrombosis associated with novel substitution (gamma346Gly-->Val) at an absolutely conserved site in the fibrinogen gamma chain. PMID: 23348147
    42. fibrinogen gamma' may contribute to the development of portal vein thrombosis PMID: 23306717
    43. Clot lysis time showed a stronger relationship with fibrinogen gamma' than with total fibrinogen, whereby increased fibrinogen gamma' delayed clot lysis. PMID: 23422752
    44. HepG2 cell gamma' fibrinogen is disproportionately up-regulated by inflammatory responses induced by interleukin-6. PMID: 23036532
    45. A novel congenital Fibrinogen Melbourne hypodysfibrinogenemia caused by g326Cys-Phe in the fibrinogen gamma chain, presenting as massive splanchnic venous thrombosis, has been described in one patient and his asymptomatic father. PMID: 22760446
    46. Fibrinogen gamma' is associated with the formation of mechanically weaker, non-uniform clots composed of thin fibers. This is caused by direct disruption of protofibril formation by gamma'. PMID: 22463367
    47. Fibrinogen residue gammaAla341 is important for the proper conformation of the gamma-module, maintaining calcium-binding site and 'A-a' interactions. PMID: 22437918
    48. mechanical unraveling of fibrin(ogen) is determined by the combined molecular transitions that couple stepwise unfolding of the gamma chain nodules and reversible extension-contraction of the alpha-helical coiled-coil connectors PMID: 22078561
    49. gamma' fibrinogen is associated with prevalent cardiovascular disease and with SNPs exclusively in and near the fibrinogen gene locus. PMID: 21757653
    50. potential biomarker for assessing a patient's inflammatory state and associated cardiovascular disease risk PMID: 21174007

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  • 相關(guān)疾?。?/div>
    Congenital afibrinogenemia (CAFBN); Dysfibrinogenemia, congenital (DYSFIBRIN)
  • 亞細(xì)胞定位：
    Secreted.
  • 組織特異性：
    Detected in blood plasma (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3694

    OMIM: 134850

    KEGG: hsa:2266

    STRING: 9606.ENSP00000336829

    UniGene: Hs.727584