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Recombinant Human Gamma-crystallin B (CRYGB)

  • 中文名稱：
    Recombinant Human Gamma-crystallin B(CRYGB)
  • 貨號(hào)：
    CSB-EP006018HU
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP006018HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CRYGB.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP006018HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CRYGB.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    CRYGB
  • Uniprot No.：
  • 別名：
    CRYGB; CRYG2Gamma-crystallin B; Gamma-B-crystallin; Gamma-crystallin 1-2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length
  • 來源：
    E.coli
  • 分子量：
    24.9 kDa
  • 表達(dá)區(qū)域：
    1-175aa
  • 氨基酸序列
    MGKITFYEDRAFQGRSYECTTDCPNLQPYFSRCNSIRVESGCWMIYERPNYQGHQYFLRRGEYPDYQQWMGLSDSIRSCCLIPPHSGAYRMKIYDRDELRGQMSELTDDCISVQDRFHLTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRVMDLY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer，50% glycerol
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Crystallins are the dominant structural components of the vertebrate eye lens.
  • 基因功能參考文獻(xiàn)：
    1. Glycation of human gammaB-crystallin PMID: 28013006
    2. Allelic variant frequency of the gamma-crystallin promoter (g(-47) ->a) affects the level of its expression in platelets from cataract patients. PMID: 26552302
    3. Complex heterogeneous mutations in the gammaB crystallin gene have been described resulting in autosomal dominant congenital cataracts with three distinct phenotypes (lamellar, anterior polar, and complete cataracts) in the same family. PMID: 23288985
    4. -47C allele of rs2289917 in CRYGB showed the strongest association with cataract. PMID: 21941057
    5. The alphaB-crystallin oligomers formed long-lived stable complexes with their gammaD-crystallin substrates. PMID: 20621668
    6. In gammaD-crystallin, methylation is exclusively at Cys 110, whereas in gammaC- and gammaB-crystallins, the principal methylation site is Cys 22 with minor methylation at Cys 79 PMID: 12876325
    7. Possible sites for posttranslational modifications in gamma B crystallin. PMID: 14517968

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  • 相關(guān)疾?。?/div>
    Cataract 39, multiple types (CTRCT39)
  • 蛋白家族：
    Beta/gamma-crystallin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2409

    OMIM: 123670

    KEGG: hsa:1419

    STRING: 9606.ENSP00000260988

    UniGene: Hs.248102