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  4. Recombinant Human Glutamate receptor ionotropic, NMDA 2D (GRIN2D), partial

Recombinant Human Glutamate receptor ionotropic, NMDA 2D (GRIN2D), partial

  • 中文名稱：
    人GRIN2D重組蛋白
  • 貨號：
    CSB-YP009915HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GRIN2D重組蛋白
  • 貨號：
    CSB-EP009915HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GRIN2D重組蛋白
  • 貨號：
    CSB-EP009915HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GRIN2D重組蛋白
  • 貨號：
    CSB-BP009915HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GRIN2D重組蛋白
  • 貨號：
    CSB-MP009915HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    EB11; estrogen receptor binding CpG island; GluN2D; Glutamate [NMDA] receptor subunit epsilon 4; Glutamate [NMDA] receptor subunit epsilon-4; Glutamate receptor ionotropic; glutamate receptor ionotropic NMDA 2D; Glutamate receptor, ionotropic, N-methyl D-aspartate 2D; Grin2d; N methyl D aspartate receptor subtype 2D; N methyl d aspartate receptor subunit 2D; N-methyl D-aspartate receptor subtype 2D; NMDA 2D; NMDAR2D; NMDE4; NMDE4_HUMAN; NR2D
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition.
  • 基因功能參考文獻(xiàn)：
    1. This study found that NMDAR activation, NR2D in particular, is involved in human fetal lung fibroblast proliferation and collagen production through a potential ERK1/2-mediated mechanism. PMID: 28987794
    2. High GRIN2D expression is associated with colorectal cancer. PMID: 26943033
    3. This study showed that the higher GluN2D mRNA level in healthy but not in depressed pregnant women as compared to non-pregnant individuals. PMID: 28284346
    4. GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers PMID: 27616483
    5. After 7 days of chronic alcohol exposure, there are significant increases in mRNA expression of GRIN2D in cultured neurons derived from alcoholic subjects, but not in cultures from nonalcoholics. PMID: 22486492
    6. Absence of truncating mutation in GRIN1 and GRIN2D genes in patients with autism spectrum disorder and schizophrenia and controls. PMID: 22833210
    7. In microsatellite instable and microsatellite and chromosomally stable cancers, CIMP and BRAF/KRAS mutations are similarly distributed indicating common mechanisms of tumor initiation or progression in the molecular pathogenesis. PMID: 21915661
    8. data show that the NMDAR2D was specifically expressed in cultivated keratinocytes PMID: 16328341

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  • 相關(guān)疾?。?/div>
    Epileptic encephalopathy, early infantile, 46 (EIEE46)
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glutamate-gated ion channel (TC 1.A.10.1) family, NR2D/GRIN2D subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4588

    OMIM: 602717

    KEGG: hsa:2906

    STRING: 9606.ENSP00000263269

    UniGene: Hs.445015