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  4. Recombinant Human Inhibin beta B chain protein (INHBB), partial

Recombinant Human Inhibin beta B chain protein (INHBB), partial

  • 中文名稱：
    人INHBB重組蛋白
  • 貨號：
    CSB-EP011720HU1
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    16.5 kDa
  • 表達(dá)區(qū)域：
    295-405aa
  • 氨基酸序列
    ECDGRTNLCCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    13-23 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
  • 基因功能參考文獻(xiàn)：
    1. Results found that INHBB expression was reduced in nasopharyngeal carcinoma (NPC) tissues, and associated with lymph node metastasis. Further data revealed that INHBB could suppress anoikis resistance and migration of NPC cells by the TGF-beta signaling pathway, decrease p53 overexpression, and could serve as a potential biomarker for NPC metastasis and prognosis . PMID: 30151927
    2. Presence of varicocele was associated with lower serum inhibin B. PMID: 27423503
    3. Elevated activin B levels together with normal activin A levels identified patients with the diagnostic symptoms of chronic fatigue syndrome/myalgic encephalomyelitis. PMID: 28302133
    4. Results identified Inhbb as one factor mediating the proliferative effect of Pdx-1 on islet cells. PMID: 27620967
    5. Low activin B level is associated with tubal ectopic pregnancy. PMID: 26968108
    6. Pregnant Han Chinese women carrying the rs7579169 CC genotype and G-G-C haplotype are significantly more likely to develop pre-eclampsia, especially late-onset and multiparous cases. PMID: 26313529
    7. We report here an original observation that activin-B is upregulated in the human idiopathic pulmonary fibrosis lung. PMID: 25361680
    8. reduction of RhoA signaling by Activin B together with persistent Rac1 activity is a prerequisite for inducing an invasive phenotype in clear cell renal cell carcinoma. PMID: 25343250
    9. inhibin B and anti-Mullerian hormone serum concentrations did not provide an additional diagnostic tool for male infertility PMID: 25581422
    10. inhibin B levels, but not FSH, are increased in primary hypothyroidism, which is consistent with a hypogonadotrophic hypogonadal state affecting the reproductive segment of the gonadotrophic axis PMID: 23692058
    11. There are significant differences in serum inhibin B levels in patients with diminished ovarian reserve before and after supplementation with dehydroepiandrosterone (DHEA). PMID: 23664458
    12. Inhibin B production was decreased following recombinant human chorionic gonadotropin administration in both control and polycystic ovary syndrome women. PMID: 24188875
    13. Inhibin B was measured in plasma samples obtained from 34 healthy male subjects selected on criteria typical for a phase I clinical trial across a wide age range. PMID: 23349064
    14. Data indicate that neither serum inhibin B nor follicle-stimulating hormone (FSH) is a suitable surrogate for determination of sperm concentration in a semen sample. PMID: 23423746
    15. The signaling pathway responsible for hepcidin up-regulation in the inflammatory context is still not understood completely. Activin B has an unexpected but crucial role in the induction of hepcidin by inflammation. PMID: 22611157
    16. A genome-wide association study for preeclampsia in unrelated Australian individuals of Caucasian ancestry was performed to genotype single nucleotide polymorphisms the Inhibin, beta B gene on 2q14.2, in preeclampsia and normal pregnancy controls. PMID: 22432041
    17. inhibin-betaB subunit appears not to be a useful prognostic marker regarding endometrioid adenocarcinomas. PMID: 21938679
    18. Compared with antimullerian hormone (AMH), stimulated serum inhBB is a more accurate predictor of ovarian response in patients undergoing in vitro fertilization. PMID: 21843890
    19. Inhibin B constitutes a reliable marker of Sertoli cell function as well as spermatogenesis, while the clinical significance of anti-Mullerian hormone in men with varicocele remains to be elucidated. PMID: 21285453
    20. High inhibin beta B is associated with cervical intraepithelial neoplasia grades 1 and 2 compared to cervix uteri. PMID: 21475087
    21. Inhibin B and antimullerian hormone have a role in gonadal function after treatment for medulloblastoma or posterior fossa ependymoma during childhood PMID: 21168856
    22. A variant in the fibrillin-3 gene is associated with TGF-beta and inhibin B levels in women with polycystic ovary syndrome. PMID: 20630504
    23. The aim of the present study is to investigate the effect of obesity on testicular function by evaluating reproductive hormones, inhibinB, insulin-like 3(INSL3), and leptin, in obese and non-obese adolescents according to pubertal Tanner stages. PMID: 20713036
    24. Serum inhibin-b levels decrease nonlinearly during the daytime, and are positively correlated with sperm counts, but the predictive power is best when inhibin-b is low. PMID: 20149358
    25. Antral follicle size influences serum inhibin B and FSH levels and alters their expected relationship with the number of antral follicles on day 3 PMID: 19061996
    26. Gonads in anorexia nervosa with weight gain have low level of activity. Inhibin B is early marker of gonadal activity, and with weight gain, awakening of the reproductive function is gradual. PMID: 15070953
    27. Inhibin B pubertal surge is prominent signal of gonadal maturation in females as well as in males. Significantly higher in boys than in girls. Review. PMID: 15319819
    28. The expression of inhibin betaB by Sertoli cells is dependent on the coexistence of spermatogenic activity within these seminiferous tubules and is low in patients with Sertoli cell only syndrome. PMID: 15551748
    29. Ovulatory cycles were characterized by higher FSH and lower inhibin B leveels in hypergonadotropic hypogonadism or premature ovarian failure. PMID: 15562017
    30. Regular increase of inhibin B(InhB) during puberty. In first phases of gonadal maturation, InhB and FSH correlate positively, while in mid-late stages relationship is inverse. In mid-puberty (G3-G4), serum InhB increases. PMID: 15757857
    31. Exposure of the cells of Sertoli to excessive amounts of lead results in inappropriate inhibin B overproduction that may be involved in the impairment of spermatogenesis. PMID: 15910540
    32. inhibin B may have a role in male fecundity PMID: 16024538
    33. INHBB expression was high in human adipocytes, reduced by weight loss and adipose tissue INHBB mRNA levels correlated to metabolic risk factors. PMID: 16650820
    34. A significant down-regulation of inhibin-beta (B) subunit in extravillous trophoblast cells in IUGR syncytiotrophoblast cells was demonstrated. PMID: 16670820
    35. Preoperative serum inhibin B concentration could not reliably predict a response to varicocelectomy, but the increase in inhibin B levels after treatment might suggest an improvement in testicular function. PMID: 16728349
    36. Follistatin was overexpressed while both activin subunits were downregulated in the majority of rat and human liver tumours PMID: 16935389
    37. The present findings showed that treatment with vaginal estroprogestinic decreases serum inhibin A and inhibin B levels, the follicular diameter PMID: 16989826
    38. Varicocele sclerotherapy improves inhibin B levels and seminal parameters. PMID: 17376219
    39. it is not clear that inhibin B does not seem to play any role in the mechanism of action of laparoscopic ovarian diathermy [letter] PMID: 17525068
    40. Granulosa cell production of inhibin B is reduced by pharmacologically induced increase in the intrafollicular androgen levels. PMID: 17628551
    41. decreased levels of inhibin b are associated with hot flushes, aches, joint pain, stiffness and depressed mood in the stages of menopausal transition. PMID: 17666595
    42. Activin B is a potent inducer of Pdx1 as well as Shh in differentiating embryonic stem cell derived embryoid bodies PMID: 17761145
    43. Activin and estrogen crosstalk regulates transcription in human breast cancer cells. PMID: 17914098
    44. Used monoclonal antibody to xenopus laevis Inhbb in ELISA for detection of human Inhbb. PMID: 17991484
    45. Expression of the beta-B subunit is related to decidualization and can be detected in the circulation as activin B. PMID: 18381568
    46. The degree of inhibin B increment during controlled ovarian stimulation provides a way for for predicting ovarian response to ovarian stimulation. PMID: 18555227
    47. There was no significant association of (log)inhibin B profiles with age at final menstrual period. PMID: 18593767
    48. Functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators. PMID: 18927237
    49. Serum inhibin B and estradiol concentrations obtained shortly after Gn therapy may offer an accurate and early prediction of ovarian response. PMID: 19198021
    50. Inhibin B is more potent than inhibin A in suppressing FSH in vitro and in vivo, and this difference in bioactivity is not explained by its affinity to betaglycan or activin type II receptors. PMID: 19589860

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6067

    OMIM: 147390

    KEGG: hsa:3625

    STRING: 9606.ENSP00000295228

    UniGene: Hs.1735