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Recombinant Human Integrin beta-like protein 1 (ITGBL1)

In Stock
  • 中文名稱：
    人ITGBL1重組蛋白
  • 貨號：
    CSB-EP011893HU
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    ITGBL1
  • Uniprot No.：
  • 別名：
    ITGBL1; OSCP; TIED; Integrin beta-like protein 1; Osteoblast-specific cysteine-rich protein; Ten integrin EGF-like repeat domain-containing protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    58.9 kDa
  • 表達(dá)區(qū)域：
    24-494aa
  • 氨基酸序列
    VPQSFSPSLRSWPGAACRLSRAESERRCRAPGQPPGAALCHGRGRCDCGVCICHVTEPGMFFGPLCECHEWVCETYDGSTCAGHGKCDCGKCKCDQGWYGDACQYPTNCDLTKKKSNQMCKNSQDIICSNAGTCHCGRCKCDNSDGSGLVYGKFCECDDRECIDDETEEICGGHGKCYCGNCYCKAGWHGDKCEFQCDITPWESKRRCTSPDGKICSNRGTCVCGECTCHDVDPTGDWGDIHGDTCECDERDCRAVYDRYSDDFCSGHGQCNCGRCDCKAGWYGKKCEHPQSCTLSAEESIRKCQGSSDLPCSGRGKCECGKCTCYPPGDRRVYGKTCECDDRRCEDLDGVVCGGHGTCSCGRCVCERGWFGKLCQHPRKCNMTEEQSKNLCESADGILCSGKGSCHCGKCICSAEEWYISGEFCDCDDRDCDKHDGLICTGNGICSCGNCECWDGWNGNACEIWLGSEYP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    A cDNA sequence coding for integrin beta-like protein 1 (ITGBL1) was inserted a 10xHis-tag at the N-terminus ＆ a Myc-tag at the C-terminus and then expressed in E.coli. The product is a full-length of mature protein consisting of 24-494AA of human ITGBL1. It has a calculated molecular weight of 58.9 kDa. And it got over 90% in purity determined by SDS-PAGE. This recombinant ITGBL1 protein is in-stock now.

    ITGBL1 is a β-integrin-related extracellular matrix (ECM) protein and involved in the development and metastasis of many tumors. Studies showed that ITGBL1 could promote bone metastasis of breast cancer through the TGF-β signaling pathway. It also stimulated the invasion of ovarian cancer cells via Wnt/planar cell polarity (PCP) signaling and focal adhesion kinase (FAK)/Src pathway. High expression of ITGBL1 was related to the poor prognosis and drug resistance of ovarian cancer.

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻(xiàn)：
    1. Characterization of gene expression profiles in hepatitis B-related liver fibrosis patients identified ITGBL1 and its interactions with TGFB1 as key regulators of fibrogenesis. PMID: 28262670
    2. ITGBL1 was associated with cell adhesion. PMID: 29772438
    3. our results suggest that ITGBL1 is a novel tumor suppressor in non-small cell lung cancer progression. PMID: 26307393
    4. ITGBL1 might be a novel biomarker for ovarian cancer diagnosis. PMID: 27261588
    5. Data indicate the transforming growth factor beta (TGFbeta) signaling pathway as a downstream effector of integrin beta-like 1 (ITGBL1) and the transcription factor Runx2 as an upstream activator of ITGBL1 expression. PMID: 26060017

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  • 亞細(xì)胞定位：
    Secreted.
  • 組織特異性：
    Widely expressed in many tissues, but readily detectable only in aorta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6164

    OMIM: 604234

    KEGG: hsa:9358

    STRING: 9606.ENSP00000365351

    UniGene: Hs.696554