Recombinant Human Interleukin-21 receptor (IL21R), partial
-
中文名稱:人IL21R重組蛋白
-
貨號:CSB-YP862061HU
-
規(guī)格:
-
來源:Yeast
-
其他:
-
中文名稱:人IL21R重組蛋白
-
貨號:CSB-EP862061HU
-
規(guī)格:
-
來源:E.coli
-
其他:
-
中文名稱:人IL21R重組蛋白
-
貨號:CSB-EP862061HU-B
-
規(guī)格:
-
來源:E.coli
-
共軛:Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
-
其他:
-
中文名稱:人IL21R重組蛋白
-
貨號:CSB-BP862061HU
-
規(guī)格:
-
來源:Baculovirus
-
其他:
-
中文名稱:人IL21R重組蛋白
-
貨號:CSB-MP862061HU
-
規(guī)格:
-
來源:Mammalian cell
-
其他:
產(chǎn)品詳情
-
純度:>85% (SDS-PAGE)
-
基因名:
-
Uniprot No.:
-
別名:CD360; IL 21R; IL-21 receptor; IL-21R; IL21 receptor; IL21R; IL21R_HUMAN; Interleukin 21 receptor; Interleukin-21 receptor; MGC10967; NILR; Novel interleukin receptor
-
種屬:Homo sapiens (Human)
-
蛋白長度:Partial
-
蛋白標(biāo)簽:Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式:Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復(fù)溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
-
儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
-
保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
-
注意事項(xiàng):Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
Datasheet :Please contact us to get it.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
功能:This is a receptor for interleukin-21.
-
基因功能參考文獻(xiàn):
- The number of IL-2-dependent FoxP3(+) regulatory T cells is increased in the peripheral blood of human patients with loss-of-function mutations in the IL-21 receptor (IL-21R). PMID: 28303891
- bone marrow monocytes from multiple myeloma patients show distinct features compared to those from patients with indolent monoclonal gammopathies, supporting the role of IL21R over-expression by bone marrow CD14(+) cells in enhanced osteoclast formation. PMID: 28057743
- Report increased levels of IL-21R in the skeletal muscle endothelial cells of patients with peripheral arterial disease compared to control individuals. PMID: 26705256
- expression of IL-21 and IL-21R were up-regulated in autoimmune thyroid disease and may be involved in the pathogenesis of the disease through augmenting aberrant immune cascade PMID: 25647271
- interleukin-21 receptor deficiency is associated with Severe Combined Immunodeficiency. PMID: 25398835
- IL-21R on B cells is upregulated in allergic rhinitis patients when compared to controls. IL-21/IL-21R may be involved in the regulation of allergic reactions through the inhibition of IgE. PMID: 25007029
- IL-21/IL-21R could act as potential biomarkers presenting early systemic sclerosis skin lesions severity. PMID: 25500255
- STAT3 signaling downstream of IL-23R and IL-21R has a role in controlling human mucosal-associated invariant T cells and NKT cell numbers PMID: 25941256
- Human neutrophils in peripheral blood express functional IL-21 receptors. PMID: 24728504
- IL-21R gene polymorphisms and serum IL-21 levels predict virological response to interferon-based therapy in Asian chronic hepatitis C patients. PMID: 23296193
- Abundant expression of interleukin-21 receptor in follicular lymphoma cells is associated with more aggressive disease. PMID: 23098230
- Data suggest that IL21 rs2221903 and IL21R rs3093301 polymorphisms may, independently or interactively, affect the susceptibility to and/or persistence of HBV infection potentially through altering IL-21 and IgE production. PMID: 23354321
- The IL-21R/STAT3 pathway is required for many aspects of human CD8(+) T-cell behavior but in some cases can be compensated by other signals. PMID: 23830147
- Human monocyte-like THP-1 cells express two IL-21 receptor components, CD132 (gammac) and IL-21Ralpha, on their cell surface, as assessed by flow cytometry. PMID: 23396946
- human IL-21R deficiency causes an immunodeficiency and highlights the need for early diagnosis PMID: 23440042
- For risk-factor studies, anti-citrullinated peptide antibody-positive (CCP)-negative rheumatoid arthritis patients can be studied as one group via measurement of their IL-21 and IL-21 receptor levels. PMID: 22032620
- Crystal structure of IL-21 binding to IL-21R reveals that the WSXWS motif of IL-21R is C-mannosylated at the first tryptophan. PMID: 22235133
- IL21R and vezatin were also cleaved in apoptotic HeLa cells with the cleavage sites Asp344, Asp655 and Asp53. PMID: 21524651
- Data suggest that the association of 2009 H1N1 vaccine-induced Ab responses with IL-21/IL-21R upregulation and with development of memory B cells and plasmablasts has implications for future research in vaccine design. PMID: 21531891
- These findings suggest role(s) for IL-21 in both the acute and chronic stages of multiple sclerosis via direct effects on T and B lymphocytes and, demonstrated for the first time, also on neurons. PMID: 21281812
- parathyroid hormone (PTH) and interleukin 21 receptor (IL21R), achieved consistent association results for bone mineral density in both discovery and replication samples. PMID: 19874204
- IL-21R is expressed in follicular lymphoma cells from early diagnosed, untreated patients. It mediates apoptosis. It is heterogenously expressed by human FL cell lines bearing the t(14;18) translocation. PMID: 20193734
- This report provides the first evidence that WSB-2 is a regulator of IL-21R expression and IL-21-induced signal transduction. PMID: 20059963
- IL-21R is associated with the activated phenotype of rheumatoid arthritis synovial fibroblasts independently of the major proinflammatory cytokines IL-1beta and TNFalpha, but not with the destruction of articular cartilage and bone. PMID: 15146416
- The up-regulation of IL-21R in keratinocytes indicates that its expression pattern is not only altered but it appears to be independent of key cytokines that are operant in systemic scleosis. PMID: 15751077
- TCR-induced IL-21R expression is driven by TCR-mediated augmentation of Sp1 protein levels and may partly depend on the dephosphorylation of Sp1 PMID: 16260592
- surface IL-21 receptor is expressed at variable levels by chronic lymphocytic leukemia B cells PMID: 16391014
- IL-21 differentially regulates IL-4-induced IgE production, via its growth- and differentiation-promoting capacities on isotype- committed B cells, & via its ability to induce IFNg production; the outcome depends on the presence of a IL-21R polymorphism. PMID: 17015683
- IL-21R is overexpressed in the inflamed synovial membrane and in peripheral blood or synovial fluid leukocytes of RA patients. Thus, blockade of IL-21R signalling pathway may have a therapeutic potential in acute RA patients. PMID: 17032244
- Data suggest a contribution of IL21 and IL21R to genetic susceptibility to type 1 diabetes and possible involvement of IL-21 and its receptor system in the disease pathogenesis. PMID: 17462506
- Follicular lymphoma cells showed exceptionally high IL-21R expression. IL-21 induced apoptosis in follicular lymphoma cells expressing high levels of IL-21 receptor. PMID: 17624663
- These results suggest an important role for IL-21R in the mobilization of skin dendritic cells to draining lymph nodes and the subsequent allergic response to epicutaneously introduced antigen. PMID: 19075398
- analyzed the transcriptional differences between B-cell subsets by gene expression profiling, and identified 15 genes significantly correlated to survival/proliferation. Among them, IL-21R and TCL1 were highly expressed in naive B cells. PMID: 19230867
- Increased IL-21R is associated with inflammatory bowel disease. PMID: 19322899
- Tax1 transactivates the interleukin-21 (IL-21) and its receptor (IL-21R) genes in human T-cells. PMID: 19617351
- A polymorphism within IL21R confers risk for systemic lupus erythematosus. PMID: 19644854
顯示更多
收起更多
-
相關(guān)疾?。?/div>IL21R immunodeficiency (IL21RID)亞細(xì)胞定位:Membrane; Single-pass type I membrane protein.蛋白家族:Type I cytokine receptor family, Type 4 subfamily組織特異性:Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.數(shù)據(jù)庫鏈接:
Most popular with customers
-
Recombinant Human Tumor necrosis factor ligand superfamily member 9 (TNFSF9), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Cytokine receptor common subunit beta (CSF2RB), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Tissue factor pathway inhibitor (TFPI), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Claudin-4 (CLDN4)-VLPs (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Human Mucin-17 (MUC17), partial (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Mouse Gastric inhibitory polypeptide receptor (Gipr), partial (Active)
Express system: Mammalian cell
Species: Mus musculus (Mouse)
-
Recombinant Human Interleukin-2 (IL2) (Active)
Express system: Mammalian cell
Species: Homo sapiens (Human)
-
Recombinant Macaca fascicularis C-type lectin domain family 4 member C(CLEC4C), partial (Active)
Express system: Mammalian cell
Species: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)