Recombinant Human Low molecular weight phosphotyrosine protein phosphatase (ACP1)
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中文名稱:Recombinant Human Low molecular weight phosphotyrosine protein phosphatase(ACP1),Yeast
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貨號:CSB-YP001176HU
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規(guī)格:
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來源:Yeast
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其他:
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中文名稱:Recombinant Human Low molecular weight phosphotyrosine protein phosphatase(ACP1),Yeast
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貨號:CSB-EP001176HU-B
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規(guī)格:
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來源:E.coli
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共軛:Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他:
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中文名稱:Recombinant Human Low molecular weight phosphotyrosine protein phosphatase(ACP1),Yeast
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貨號:CSB-BP001176HU
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規(guī)格:
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來源:Baculovirus
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其他:
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中文名稱:Recombinant Human Low molecular weight phosphotyrosine protein phosphatase(ACP1),Yeast
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貨號:CSB-MP001176HU
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規(guī)格:
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來源:Mammalian cell
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其他:
產(chǎn)品詳情
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純度:>85% (SDS-PAGE)
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基因名:ACP1
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Uniprot No.:
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別名:Acid phosphatase 1 soluble; Acid phosphatase of erythrocyte ; ACP1; Adipocyte acid phosphatase; Cytoplasmic phosphotyrosyl protein phosphatase; HAAP; LMW-PTP; LMW-PTPase; Low molecular weight cytosolic acid phosphatase; Low molecular weight phosphotyrosine protein phosphatase; PAP1; PAP2; phosphatase; acid; of erythrocyte; PPAC_HUMAN; Protein tyrosine phosphatase; PTPase; Purple acid phosphatase; Red cell acid phosphatase 1; testicular secretory protein Li 37
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種屬:Homo sapiens (Human)
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蛋白長度:full length of Isoform 1
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表達區(qū)域:1-158
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氨基酸序列MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
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蛋白標簽:Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式:Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet :Please contact us to get it.
相關產(chǎn)品
靶點詳情
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功能:Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
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基因功能參考文獻:
- ACP1 may have an important role in regulation of the multiple systems associated with suicide. PMID: 28668716
- Conditioned medium from MDA-MB-231 breast cancer cells with total knockdown of LMW-PTP, but not of slow isoform LMW-PTP, significantly reduced osteoclast differentiation of RAW 264.7 cells. PMID: 29187443
- results confirm the role of TPH1, TPH2, 5HT2A, CRHR1 and ACP1 variants in the risk of suicidal behavior. PMID: 27479537
- These data support that PTPN22 1858C/T, PTPRJ 2965C/G and 1176 A/C polymorphisms and ACP1 A, B and C alleles are not associated with a higher risk of immune thrombocytopenia P in adults. PMID: 27309885
- The LMW-PTP slow isoform can be an important protein in bone metastatic disease, with a fundamental role in the interplay between tumor cells and osteoclasts, through the regulation of Src activity and IL-8 secretion. PMID: 27127127
- Overexpression of LMWPTP in prostate cancer confers a malignant phenotype with worse clinical outcome. PMID: 26159288
- ADA6, PTPN22 and ACP1 are involved in immune reactions: since endometriosis has an autoimmune component. PMID: 26216523
- LMPTP expression increases in end-stage heart failure in humans PMID: 26213100
- Suggest that hypermethylation of ACP1, BMP4, and TSPYL5 are common events in HCC and could be used as potentially detectable biomarkers in HCC tissues. PMID: 26386860
- the present study found that the ACP1*C allele, previously associated with an increased vulnerability to infectious/parasitic diseases may also be able to shape behavioral immune defenses by interaction with the level of E. PMID: 24933463
- Association of an increased risk of coronary artery disease, especially in females, with ACP1 polymorphisms. PMID: 25846885
- ACP1 knockdown attenuates effects of osmotic stress in HaCaT cells, mainly in the status of Src kinase, Rac and STAT5 phosphorylation and activity. PMID: 25781955
- The rs3828329 of ACP1 gene is also a risk factor of CAD in Han Chinese females aged 65 years and older. PMID: 25123136
- ACP1 polymorphism is associated with type 1 diabetes mellitus. PMID: 25125338
- In ACP1 *B/*C genotype, which shows the highest enzymatic activity, spermatic concentration is significantly lower and atypical spermatozoa are significantly more frequent as compared to other ACP1 genotypes. PMID: 23278455
- In Class 3 people the combination of high ACP f-isozyme concentration and the ADA*2 allele, lowers the rate of glycolysis that may reduce the amount of metabolic calories and activates Sirtuin genes that protect cells against age-related diseases. PMID: 23959645
- certain genotypes of ACP1 associated with high phosphatase activity may increase the T-cell response to PF4-heparin complexes, with higher levels of circulating antibodies PMID: 23621699
- A significant increase of PTPN22 *T allele in endometriosis is observed in women carrying ACP1*C allele, in women carrying p53 codon 72 *Pro allele PMID: 23453606
- clarification of the importance of ACP1 in carcinogenesis through the analysis of LMW-PTP interaction with different substrates [review] PMID: 23584899
- The data suggest an interaction between p53 codon 72 and ACP wherein a positive effect of the p53 *Pro allele on susceptibility to coronary artery disease occurs. PMID: 23197232
- mRNA expression of the slow isoform was increased in breast cancer and that of the fast isoform was reduced in breast cancer. PMID: 23645747
- balanced redox-state is required for VEGF to facilitate reversible S-glutathionylation of LMW-PTP, FAK activation and endothelial cell migration PMID: 22854047
- lack of association with inflammatory bowel disease in Spanish patients PMID: 22428720
- There is a significant association between acid phosphatase locus 1 (ACP(1) and cancer grade, mainly due to ACP(1) genotypes carrying the *C allele that are much less represented in patients with low grade when compared with those with high grade. PMID: 22692348
- the ACP1 protein is a tyrosine phosphatase that influences Wnt signaling, a pathway regulated by lithium, making ACP1 a functional candidate for involvement in the phenotype. PMID: 21423239
- Data indicate that ACP1 rs11553742*T with increased susceptibility in systemic lupus erythematosus (SLE) patients. PMID: 22064183
- Gain of the telomeric region 2p25.3 harboring the ACP1 gene is common in CLL (25%, 44 of 178 cases). PMID: 22035742
- the ACP1*C allele influences the risk of cardiovascular disease events in patients with rheumatoid arthritis. PMID: 21767392
- Although both variants dephosphorylate the EPHA2 receptor, the rate and specificity of dephosphorylation for specific tyrosines are different for ACP1 and human cytoplasmic protein tyrosine phosphatase-B. PMID: 21538645
- investigated hypothesis that favism is caused by toxic Vicia faba substances, which in some ACP1 phenotypes cause increased phosphorylation and thus increased glycolysis, with strong reduction in reduced glutathione production, resulting in hemolysis PMID: 21644204
- In overweight women (BMI > 25), the proportion of low activity ACP1 phenotypes is much lower in type 1 diabetes than in gestational diabetes and in healthy females. PMID: 19855922
- the correlation between blood glucose and glycated Hb in relation to AK1 and ACP1 polymorphism was studied. PMID: 20152999
- Type 1 diabetes subjects show a highly significant increase of ACP1*A/ADA1*2 gametic type compared with healthy subjects from the same population (P = 0.003). PMID: 20805743
- association with coronary artery disease evident only in diabetic subjects and dependent on female gender PMID: 20581655
- A significant interaction between ACP1 and ADA1 concerning susceptibility to type 1 diabetes, was revealed. PMID: 19789510
- ACP1 is associated with allergy PMID: 12100313
- Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes. PMID: 12640337
- LMW-PTP has a role in immunological synapse establishment and stabilization through the negative control of FAK activity and of cell surface receptor redistribution PMID: 12815062
- The analysis involved the data on nine polymorphic codominant loci: HP, GC, TF, PI, PGM1, GLO1, C3, ACP1, and ESD. The loci were selected by significance of differences in genotype frequencies between tuberculosis patients and healthy controls PMID: 12942785
- We show that the association of STAT5 and LMW-PTP does not exclusively involve the phosphatase active site and phosphotyrosine residue of STAT5. PMID: 14637146
- acid phosphatase 1 contributes to the clinical manifestations of type 2 diabetes and probably also have a marginal influence on susceptibility to the disease PMID: 15281007
- complex interaction among maternal age, sex of infant and ACP1 concerning age at diagnosis of diabetes PMID: 15586390
- Finds ACP1*C is a recessively deleterious allele that reduces viability during early life stages and is not maintained by overdominant selection in European populations. PMID: 15974295
- Significant correlations between LMW-PTP overexpression and the most common clinical-pathological features of cancers exist. In colon cancer and neuroblastoma increased total LMW-PTP mRNA expression correlates with unfavourable outcome. PMID: 16036221
- Crystal structure of the second human low molecular weight PTPase isoenzyme provides the opportunity to examine the structural basis of different substrate and inhibitor/activator responses. PMID: 16253994
- mother/newborn pairs: ACP1 (acid phosphatase 1)distribution has fewer pairs with maternal low ACP1 S isoform and infant high S isoform concentration;Recurrent spontaneous abortion couples show wife low S isoform and husband high S isoform concentration PMID: 16762482
- GRX plays an important role in PDGF-BB-dependent cell proliferation by regulating the redox state of LMW-PTP PMID: 16893901
- Among newborns carrying the ACP1C allele there is an increase of Sex Ratio among the offspring of smoking mothers relative to non-smoking mothers. PMID: 16973312
- Human recombinant LMWPTP-A displayed an RN5Pase activity that was higher than its tyrosine phosphatase activity, indicating that this phosphatase may participate in protein deglycation, a new form of protein repair. PMID: 17472574
- results suggest a cooperative effect of ADA and ACP1 genetic polymorphism on the susceptibility to repeated spontaneous abortion and to some of its clinical characteristics PMID: 17565542
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亞細胞定位:Cytoplasm.
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蛋白家族:Low molecular weight phosphotyrosine protein phosphatase family
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組織特異性:T-lymphocytes express only isoform 2.
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