Recombinant Human Metabotropic glutamate receptor 5 (GRM5), partial
In Stock-
中文名稱:人GRM5重組蛋白
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貨號(hào):CSB-EP009935HU
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規(guī)格:¥1836
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圖片:
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其他:
產(chǎn)品詳情
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純度:Greater than 85% as determined by SDS-PAGE.
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基因名:
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Uniprot No.:
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別名:Glutamate receptor metabotropic 5; GPRC1E; Grm5; GRM5_HUMAN; Metabotropic glutamate receptor 5; Metabotropic glutamate receptor 5 variant F; Metabotropic glutamate receptor 5 variant G; Metabotropic glutamate receptor 5 variant H; mGlu5; mGluR5; PPP1R86; Protein phosphatase 1 regulatory subunit 86
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種屬:Homo sapiens (Human)
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蛋白長度:Partial
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來源:E.coli
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分子量:70.6 kDa
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表達(dá)區(qū)域:22-580aa
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氨基酸序列SSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEP
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. -
蛋白標(biāo)簽:N-terminal 10xHis-tagged and C-terminal Myc-tagged
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產(chǎn)品提供形式:Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
緩沖液:If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose. -
儲(chǔ)存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:3-7 business days
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注意事項(xiàng):Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet & COA:Please contact us to get it.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
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基因功能參考文獻(xiàn):
- clinical evidence for altered mGluR5 signaling in the amygdala in alcohol use disorder PMID: 29317611
- We anticipate that the resulted outcome could be supportive to discover potent negative allosteric modulators for metabotropic glutamate receptor 5 (mGluR5). PMID: 29806525
- This study provides information concerning the changes in the expression of GABAergic and glutamatergic markers in mice lacking the mGlu5. PMID: 27581816
- We report that expression of a key regulator of synaptic protein synthesis, the metabotropic glutamate receptor 5 (mGlu5) protein, is significantly reduced in both the brains of RS model mice and in the motor cortex of human RS autopsy samples. PMID: 26936821
- once at the inner nuclear membrane, mGluR5 is stably retained via interactions with chromatin and is perfectly positioned to regulate nucleoplasmic Ca(2+)in situ PMID: 28096465
- Overall, these data posit mGluR5 in key paralimbic areas as a strong determinant of the temperament trait novelty seeking. These data add to our understanding of how brain neurochemistry accounts for the variation in human behavior and strongly support further research on mGluR5 as a potential therapeutic target in neuropsychiatric disorders associated with abnormal novelty-seeking behaviors. PMID: 27283933
- Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington's disease PMID: 24969128
- The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in the pathophysiology of mood and anxiety disorders. PMID: 26645628
- The interaction between GRM5 and cellular prion protein has a central role in transgenic mouse model of Alzheimer's disease pathogenesis. PMID: 26667279
- Data suggest that metabotropic glutamate receptors recycling is completely dependent on the activity of PP2A whereas, PP2B has partial effect on this process. PMID: 26311002
- findings provide evidence for decreased expression of metabotropic glutamate receptor 5 and its signaling components representing a key pathophysiological hallmark in autism spectrum disorder. PMID: 26052099
- Study provided evidence that protein expression of mGluR5 is significantly higher (total: 42%; monomer: 25%; dimer: 52%) in the hippocampal CA1 region of schizophrenia subjects relative to healthy controls PMID: 26048293
- Results provide compelling evidence that mGluR5 regulation is altered in schizophrenia, likely contributing to the altered glutamatergic signaling that is associated with the disorder PMID: 25778620
- This review supports altered mGluR5 functioning as a convergent point in ASD pathogenesis and indicates more research is warranted into mGluR5 as a potential therapeutic target. PMID: 25704074
- both an increased and reduced mGlu5 functioning seem to be associated with Intellectual Disability and autism spectrum disorders. PMID: 24548786
- significant positive correlation between Yale-Brown Obsessive Compulsive Scale obsession sub-score and mGluR5 distribution volume ratio in the cortico-striatal-thalamo-cortical brain circuit; results suggest obsessions in particular might have an underlying glutamatergic pathology related to mGluR5 PMID: 24833114
- gnificantly higher expression level in the metabotropic receptor genes GRM5 in Locus coeruleus neurons. PMID: 24925192
- Findings demonstrate a developmental regulation of mGluR5 in the hippocampus and suggest a role for this receptor in astrocytes during early development in Down's syndrome hippocampus PMID: 25115540
- findings suggest that changes in astrocyte mGlu5 receptors may be part of an adaptive response to the progressive nature of Alzheimer's disease PMID: 19401173
- tobacco smoking was associated with lower mGluR5 availability in the brain in both cocaine users and controls, while cocaine use was not linked to detectable mGluR5 alterations PMID: 23628984
- Our findings highlight the subtleties of allosteric modulator binding to mGlu5 and demonstrate the utility in incorporating SAR information to strengthen the interpretation and analyses of docking and mutational data. PMID: 24528109
- a dysregulation of its signaling in fragile X mental retardation gene 1 premutation carriers, which would likely contribute to the development and severity of fragile X-associated tremor/atasia syndrome. PMID: 24332449
- reflected in the immunoblotting data Mglur5 receptors were detected at higher levels of expression in patient with cortical dysplasia with intractable epilepsy. PMID: 25003238
- Review provides an update of the current state of the art of mGlu5 receptor-based manipulations to alleviate the symptoms of Parkinson's disease. PMID: 24040811
- The pattern of mGluR5 expression by neural stem/progenitor cells, neuroblasts and neurons provides important anatomical evidence for the role of mGluR5 in the regulation of human hippocampal development PMID: 23225313
- This study demonistrated that mGluR5 upregulation also participates in counterbalance mechanisms along the hyperexcitable circuitry uniquely altered in TLE hippocampal formation. PMID: 23804486
- This study demonistrated that metabotropic receptor mGluR5 was found to be expressed by just 40% of striatal neurons in young individuals, with significant intensity variations among the neurons. PMID: 23627706
- this study provides evidence that GRK2 mediates phosphorylation-independent mGluR5 desensitization via the interaction between the RGS domain and Galphaq in HEK 293 cells. PMID: 23705503
- Knockdown of mGluR5 inhibited icariin induced reactive oxygen species generation and NF-kappaB nuclear translocation. PMID: 23524143
- mGluR5 inhibition and stimulation in the nucleus accumbens can regulate cocaine-seeking, and demonstrate that one mechanism for this effect is via interactions with Homer proteins PMID: 22340009
- Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury. PMID: 23478188
- mGluR5 is expressed by a variety of cells such as neural stem cells in the frontal cortex, ventricular zone and subventricular zone in human fetuses. PMID: 22543119
- data demonstrate that mGluR5 receptors internalize without the application of ligand and the internalized receptors recycle back to the cell surface following constitutive endocytosis. PMID: 22995293
- Calmodulin-regulated Siah-1A binding to mGluR5 dynamically regulates mGluR5 trafficking PMID: 23152621
- Human mGluR5, GABA(A,B), and CB(1,2) receptors are abundantly expressed along the vago-vagal neural pathway and involved in the triggering of transient lower esophageal sphincter relaxations PMID: 22256945
- the results of this study show that using the equilibrium method is an acceptable alternative to the standard kinetic method when using 18F-SP203 to measure mGluR5 PMID: 22032949
- Elevated glutamatergic transmission as measured with increased mGluR5 specific binding is associated with human motor complications; its antagonism can be targeted for patients' treatment. PMID: 20036444
- Metabotropic glutamate receptor 5 upregulation in children with autism is associated with underexpression of both Fragile X mental retardation protein and GABAA receptor beta 3 in adults with autism. PMID: 21901840
- mGluR5 promoted the proliferation of human embryonic cortical neural stem/progenitor cells PMID: 21723923
- Results highlight the therapeutic importance of mGluR5 antagonists in alpha-synucleinopathies. PMID: 21103359
- mGLUR5 and 1,4,5-InsP3 signaling control calcium release PMID: 12119301
- Data report the isolation of a novel gene termed metabotropic glutamate receptor 5-related (mGluR5R) [mGluR5R]. PMID: 12531512
- Data report the identification of a novel variant of the G-protein coupled metabotropic glutamate receptor mGlu5 (hmGlu5d) generated by alternative splicing at the C-terminal domain. PMID: 12531526
- mGlu5 on nuclear membranes has a role in mediating intranuclear Ca2+ changes in heterologous cell types and neurons PMID: 12736269
- alternative 5'-splicing and usage of multiple promoters may contribute to regulatory mechanisms for tissue- and context-specific expression of the mGluR5 gene PMID: 12783878
- activation of mGluR5 causes translocation of both gammaPKC and deltaPKC to the plasma membrane. deltaPKC, but not gammaPKC, phosphorylates mGluR5 Thr(840), leading to the blockade of both Ca2+ oscillations and gammaPKC cycling. PMID: 14561742
- We found a selective expression of the group I receptor mGluR5 in human parasympathetic Onuf's nucleus, strengthening the hypothesis that mGluR expression may provide a possible clue to the selective vulnerability in ALS. PMID: 15076751
- it is phosphorylation of Ser-839, not Thr-840, that is absolutely required for the unique Ca2+ oscillations produced by mGluR5 activation PMID: 15894802
- there is an alpha-actinin-1-dependent mGlu(5b) receptor association with the actin cytoskeleton modulating receptor cell surface expression and functioning PMID: 17311919
- We documented for the first time the expression of the mGluR5 and EAAT1 in MG-63 cells, as well as the ability of dexamethasone to upregulate the expression of the mGluR5 and EAAT1 in the MG-63 cells. PMID: 17627080
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亞細(xì)胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:G-protein coupled receptor 3 family
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