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  4. Recombinant Human Metalloproteinase inhibitor 2 protein (TIMP2)

Recombinant Human Metalloproteinase inhibitor 2 protein (TIMP2)

Unavailable
  • 中文名稱：
    人TIMP2重組蛋白
  • 貨號：
    CSB-AP000161HU
  • 規(guī)格：
    ￥10940
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% as determined by SDS-PAGE and HPLC.
  • 基因名：
    TIMP2
  • Uniprot No.：
  • 別名：
    CSC 21K; CSC-21K; CSC21K; Metalloproteinase inhibitor 2; Metalloproteinase inhibitor 2 precursor; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP-2; TIMP2; TIMP2_HUMAN; Tissue Inhibitor of Metalloproteinase 2; Tissue inhibitor of metalloproteinases 2
  • 種屬：
    Homo sapiens (Human)
  • 來源：
    E.Coli
  • 分子量：
    21.8 kDa
  • 氨基酸序列
    CSCSPVHPQQ AFCNADVVIR AKAVSEKEVD SGNDIYGNPI KRIQYEIKQI KMFKGPEKDI EFIYTAPSSA VCGVSLDVGG KKEYLIAGKA EGDGKMHITL CDFIVPWDTL STTQKKSLNH RYQMGCECKI TRCPMIPCYI SSPDECLWMD WVTEKNINGH QAKFFACIKR SDGSCAWYRG AAPPKQEFLD IEDP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    Untagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
  • 基因功能參考文獻(xiàn)：
    1. TIMP-2 may be considered as a potential non-invasive marker for the diagnosis of liver fibrosis in patients with NAFLD. PMID: 30284418
    2. UV-induced expression of DNMT1 may be responsible for mediating DNA hypermethylation in TIMP2, and thus, silencing its expression, in UV-exposed human skin. PMID: 29685765
    3. Overexpression of TIMP2 inhibited cell viability, migration and EMT process. PMID: 29432996
    4. TIMP2 was confirmed to be a direct downstream target of miR616. Inhibition of TIMP2 expression was required for the promoting effects of miR616 on the metastasis and EMT of ovarian cancer cells. PMID: 29658596
    5. TIMP2 promotes tumor progression and miR2055p directly regulates TIMP2, thereby suppressing proMMP2 activation and inhibiting oral squamous cell carcinoma cell invasiveness. PMID: 29393341
    6. Urine levels of TIMP2 (and IGFBP7) are predictive of acute kidney injury following cardiac surgical procedures. PMID: 28803769
    7. MMP-9 and TIMP-2 genes are upregulated in cancerous tissues when compared to normal bladder tissues. PMID: 28980922
    8. Overexpression of MMP2 and MMP16 in endometrial cancerous tissues corresponded to down-regulation of miR-377, miR-382 and miR-410, while decreased expression of TIMP2 was associated with miR-200b up-regulation. PMID: 28871006
    9. MiR-106a was inversely correlated with TIMP2. PMID: 28731196
    10. In squamous cell carcinoma of the cervix (SCCC), higher levels of MMP-14 expression were established in tumor cells, as evidenced by IHC (+3) and RT-PCR.Furin activity in the tumor was much higher than that in normal tissues. The expression of TIMP-2 mRNA was sufficiently obvious in both the tumor and normal tissues to the bottom of the uterine cavity. PMID: 29265076
    11. methylation differences within the TIMP2 gene promoter are not related to patellar tendinopathy PMID: 28888475
    12. This study provides evidence that TIMP-2 is a knee OA susceptibility gene in the Chinese population and a potential diagnostic and preventive marker for the disease. PMID: 27901480
    13. Tissue inhibitor of metallopeptidases 2 (TIMP2) protein and mRNA levels were downregulated after miR-15b overexpression in A549 and LTEP-a-2 cells, respectively. Our results indicate that high expression of miR-15b is associated with non-small cell lung cancer (NSCLC)and suggest that miR-15b expression may be a novel biomarker for predicting clinical outcomes in NSCLC patients PMID: 28498424
    14. study results suggest an association between matrix metalloproteinase 2, matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 2 single nucleotide polymorphisms with sperm parameters, but not infertility PMID: 27401679
    15. Long noncoding RNA DANCR promotes prostate cancer invasion and metastasis through repressing the expression of TIMP2/3 PMID: 27191265
    16. MMP2-1306C/T and TIMP2-418 G/C gene variants as risk factors for patients with relapsing remitting multiple sclerosis, was studied. PMID: 27174941
    17. biomarker for acute kidney injury PMID: 27174659
    18. epithelial cells and leukocytes from the urinary sediment. CONCLUSION: The gene expression pattern of IGFBP7 and TIMP-2 from urinary sediment, which contains desquamated renal tubular epithelial cells, did not correlate with [IGFBP7]x[TIMP-2] protein, indicating that IGFBP7 and TIMP-2 measured in the NephroCheck(R) test originated predominantly from intact but stressed cells of the kidney itself PMID: 29145491
    19. This study demonstrated that TIMP2 higher expression in glioblastoma PMID: 27633774
    20. Data show that tissue inhibitor of metalloproteinase 2 (TIMP2) is a direct target of miR-492 that modulates cervical cancer cell invasion. PMID: 28802022
    21. A higher risk of incidence or recurrent depressive disorder(OR=9.376) was confirmed in the case of a set of T/T-G/C genotypes of the MMP-9T-1702A and TIMP-2G-418C polymorphisms PMID: 27434116
    22. High TIMP2 expression is associated with acute kidney injury. PMID: 27342580
    23. expression of TIMP2 was inversely associated with miR-106a in nodule tissues. Apoptotic body was also seen under electron microscope accompanied by silencing of miR-106a. Together, this data indicated that miR-106a may act as an oncogene and contribute to gastric cancer development. PMID: 27142596
    24. Urine [TIMP-2]*[IGFBP7] is a promising candidate for early detection of AKI, especially in ruling-out AKI PMID: 28107490
    25. We conclude that in the resected esophageal cancer an increased mRNA expression of MMP-7, MMP-10 and TIMP-1 correlated with clinicopathologic features. We suggest that these genes may play a role during progression of the disease. MMP-10, MMP-7, TIMP-1, TIMP-2 were overexpressed in 73%, 85%, 55% and 42% of esophageal cancer samples, respectively. PMID: 28510611
    26. At hospital admission, all viral gastroenteritis (GE) patients viral gastroenteritis (GE) patients demonstrated increased MMP-9 and decreased MMP-2 and TIMP-2 serum levels; kinetics of serum MMP-2, MMP-9, and TIMP-2 levels were similar among the viral GE patients but distinct from bacterial enteritis patients; involvement of MMPs and TIMPs in the pathophysiology of gastrointestinal symptoms likely varies depending on the PMID: 26765397
    27. Meta-analysis indicated that urinary [TIMP-2].[IGFBP7] may be a reliable biomarker for the early detection of acute kidney injury in adults. PMID: 28682920
    28. Results show that resistant hypertension was associated with higher TIMP-2 levels and low MMP-2/TIMP-2 ratio, suggesting that these regulators of ECM remodeling play a key role in blood pressure control in this high-risk subset of hypertensive individuals. PMID: 27412873
    29. important regulator of extracellular matrix degradation and hepatocellular carcinoma metastasis PMID: 27018975
    30. TIMP-2 is both expressed and secreted preferentially by cells of distal tubule origin, while IGFBP7 is equally expressed across tubule cell types yet preferentially secreted by cells of proximal tubule origin. In human kidney tissue, strong staining of IGFBP7 was seen in the luminal brush-border region of a subset of proximal tubule cells, and TIMP-2 stained intracellularly in distal tubules. PMID: 28003188
    31. Myopia development in mammals is associated with reduced expression of TIMP-2, which contributes to increased degradative activity in the sclera. PMID: 28384717
    32. our results revealed miR-483-5p directly targeted to the cartilage matrix protein matrilin 3 (Matn3) and tissue inhibitor of metalloproteinase 2 (Timp2) to stimulate chondrocyte hypertrophy, extracellular matrix degradation, and cartilage angiogenesis, and it consequently initiated and accelerated the development of OA. PMID: 28139355
    33. Stromal TIMP-2 expression reflected its role in regulating tumor progression in ameloblastoma and in regulating developmental processes in tooth germs by their inhibitory effect on MMP-9 PMID: 26067137
    34. No significant differences were found between MMP-7 A-181G, C-115T, and TIMP-2 G-418C polymorphism and coronary artery disease and myocardial infarction in a Turkish population. PMID: 28137415
    35. High TIMP2 expression is associated with chronic myelogenous leukemia. PMID: 28035415
    36. MMP-2 and TIMP-2 were secreted by both tumor cells and stromal cells. PMID: 27853937
    37. that miR-22 acts to regulate invasion of 1321N1 astrocytoma cells by targeting TIMP2 expression PMID: 27834627
    38. Results show decreased expression of MMP-2, MMP-9 and TIMP-2 genes on both mRNA and protein levels in depression; there elevated expression positively affects cognitive efficiency. PMID: 26856768
    39. TIMP- 2 expression decreased in cervical disc herniation patients. PMID: 27173256
    40. Changes in MMPs and TIMP expression may be a common element in, or perhaps even a marker for, recurrent depressive disorders and somatic diseases. PMID: 27098106
    41. quantitative urine test is available to assess the risk of developing AKI by measuring the concentrations of two protein biomarkers, TIMP-2 and IGFBP-7 PMID: 26797672
    42. miR-22 significantly upregulated the invasion capacity of 1321N1 cells. In silico analysis predicted that TIMP2 is a target gene of miR-22 which was confirmed by qPCR and Western blotting. Luciferase reporter assays demonstrated that miR-22 directly bound the 3'-untranslated regions of TIMP2. These data suggest that miR-22 acts to regulate invasion of 1321N1 astrocytoma cells by targeting TIMP2 expression. PMID: 27834627
    43. Pathogenesis and progression of nasal polyps is closely related with elevated MMP-9 and suppressed TIMP-2 expression PMID: 26823777
    44. our results demonstrate that TIMP-2 stimulates lung adenocarcinoma cell proliferation PMID: 26556867
    45. new evidence that promoter polymorphisms in TIMP2 are functional and may affect gene transcription with possible effects on craniofacial development leading to NSCL/P. PMID: 24799419
    46. This study shows that urinary [TIMP-2]*[IGFBP7] has a good diagnostic performance in predicting adverse outcomes in neonatal and pediatric AKI of heterogeneous etiology. PMID: 26606754
    47. showed a significant association between the variants of MMP-2 and TIMP-2 promoters and spontaneous intracerebral hemorrhage PMID: 26551785
    48. TIMP2 is elevated in patients with non-alcoholic fatty liver disease. PMID: 26329758
    49. TIMP-2 interaction with MT1-MMP provides tumor cells with either pro- or anti-apoptotic signaling depending on the extracellular environment and apoptotic stimulus. PMID: 26331622
    50. MiR-761 directly targeted ING4 and TIMP2. PMID: 26278569

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Protease inhibitor I35 (TIMP) family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11821

    OMIM: 188825

    KEGG: hsa:7077

    STRING: 9606.ENSP00000262768

    UniGene: Hs.633514