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Recombinant Human Mucin-7 (MUC7)

  • 中文名稱(chēng)：
    人MUC7重組蛋白
  • 貨號(hào)：
    CSB-YP851529HU
  • 規(guī)格：
    ￥2208
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    MUC7
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 來(lái)源：
    Yeast
  • 分子量：
    95.7 kDa
  • 表達(dá)區(qū)域：
    23-377aa
  • 氨基酸序列
    RERDHELRHRRHHHQSPKSHFELPHYPGLLAHQKPFIRKSYKCLHKRCRPKLPPSPNNPPKFPNPHQPPKHPDKNSSVVNPTLVATTQIPSVTFPSASTKITTLPNVTFLPQNATTISSRENVNTSSSVATLAPVNSPAPQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETSAAPTHQTTTSVTTQTTTTKQPTSAPGQNKISRFLLYMKNLLNRIIDDMVEQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-PDI-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.
  • 基因功能參考文獻(xiàn)：
    1. The genotypic polymorphisms of IL-1beta -511 and +3954, and of MUC7 VNTR, had no direct associations with the development of BMS. However, the T allele of IL-1beta -511 may increase the risk of BMS by increasing psychological asthenia. PMID: 27246755
    2. High expression of MUC7 is associated with clear-cell renal cell carcinoma. PMID: 27683054
    3. A capsule-free mutant of S. pneumoniae TIGR4 binds to salivary proteins, most prominently to mucin MUC7, but that this binding was not mediated through PsrP or recognition of sialic acid. PMID: 26172471
    4. MUC7 glycosylation is altered in recurrent aphthous stomatitis. This may change the protective properties of this mucin against mucosal pathogens, which may effect this condition. PMID: 26051835
    5. Results identified a reduction in glycosylation of MUC7 in Sjogren's primarily due to the loss of the extended core 2 disialylated structure, with and without fucosylation and suggest that MUC7 O-glycan changes in Sjogren's Syndrome may alter the physical properties of saliva, leading to the symptom of dry mouth. PMID: 26631508
    6. The minimally invasive PTT procedure combined with Mucin 7 targeted GNPs is able to kill cancer cells and preserve healthy cells PMID: 25834826
    7. MUC7 is a salivary mucin with antimicrobial activity against bacteria and fungi. PMID: 12543672
    8. A significant increase in sulfation was identified in salivary MUC7 from rheumatoid arthritis patients. PMID: 23457413
    9. The study did not show a correlation between the MUC7 genotypes and caries. PMID: 22706105
    10. The present study did not disclose an association between MUC7*5/*6 and MUC7*6/*6 genotypes and gingival bleeding index. PMID: 23002673
    11. expression of different numbers of terminal repeats in this salivary mucin in the oral environment does not interfere with the etiopathogenesis of aggressive or chronic periodontitis PMID: 22167029
    12. MUC7 expression in ductal adenocarcinoma (DAC) and chronic pancreatitis was not statistically significant, but MUC7 could be considered as potential marker of malignant lesions, especially in pancreatic DAC, as it was positive in 73% of these cases. PMID: 21647207
    13. A novel MUC7*5-generated variable number of tandem repeat (VNTR) polymorphism decreases the likelihood of a diagnosis of asthma in an African American population. PMID: 19820409
    14. MUC5B and MUC7 from HIV patients, unlike the MUC5B and MUC7 from HIV negative individuals, did not inhibit HIV-1 activity. PMID: 20946627
    15. Structure and biosynthesis of human salivary mucins. PMID: 11996097
    16. Level of MG2 is lower in saliva of subjects with dental disease PMID: 12459324
    17. binds to Streptococcus mutans alpha-enolase [MG2] PMID: 15501816
    18. reported as new substrate for StcE protease of Escherichia coli O157-H7 in HEp-2 cells PMID: 15731026
    19. Interactions between mucin and non-mucin proteins in saliva could protect complex partners from proteolysis PMID: 16203048
    20. When the cells were treated with a panel of cytokines, epidermal growth factor, or a bacterial product (Pseudomonas aeruginosa lipopolysaccharide [LPS]), MUC7 transcripts and glycoprotein products were increased 1.7- to 3.2-fold. PMID: 16514118
    21. Data demonstrate that TNF-alpha activates MUC7 transcription via NF-kappaB signaling pathway. PMID: 16778149

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  • 相關(guān)疾病：
    Asthma (ASTHMA)
  • 亞細(xì)胞定位：
    Secreted.
  • 組織特異性：
    Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 7518

    OMIM: 158375

    KEGG: hsa:4589

    STRING: 9606.ENSP00000302021

    UniGene: Hs.631946