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  4. Recombinant Human Multidrug and toxin extrusion protein 2 (SLC47A2), partial

Recombinant Human Multidrug and toxin extrusion protein 2 (SLC47A2), partial

  • 中文名稱：
    人SLC47A2重組蛋白
  • 貨號：
    CSB-YP769788HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLC47A2重組蛋白
  • 貨號：
    CSB-EP769788HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLC47A2重組蛋白
  • 貨號：
    CSB-EP769788HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLC47A2重組蛋白
  • 貨號：
    CSB-BP769788HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLC47A2重組蛋白
  • 貨號：
    CSB-MP769788HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC47A2
  • Uniprot No.：
  • 別名：
    H(+)/organic cation antiporter kidney-specific; H+/organic cation antiporter; hMATE-2; Kidney-specific H(+)/organic cation antiporter; MATE-2; MATE2 B; MATE2 K; MATE2K; Multidrug and toxin extrusion 2; Multidrug and toxin extrusion protein 2; S47A2_HUMAN; SLC47A2; Solute carrier family 47 member 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.
  • 基因功能參考文獻(xiàn)：
    1. SLC47A2 transcriptional repression in Renal Cell Carcinoma tissues. PMID: 27821436
    2. Network and cell biological analysis additionally showed that expression of MATE2-K is regulated by Nrf2 signaling PMID: 28131833
    3. There were statistically significant association between resistance to metformin and MATE2 expression in cancer cells. PMID: 27959931
    4. These were associated with markedly reduced or increased MATE2-K function. PMID: 24985703
    5. The effect of novel promoter variants in ... MATE2 on the pharmacokinetics and pharmacodynamics of metformin PMID: 23267855
    6. MATE2, which facilitates extrusion of drugs and metabolites from blood into urine, is physically or functionally associated with cilia. PMID: 22558177
    7. 4',6-diamidino-2-phenylindole (DAPI) can be used as a probe substrate for rapid assays of the functionality of the human MATE2 PMID: 20047987
    8. characterization of MATE2-K: kinetic analysis of transport of cimetidine and tetraethylammonium; inhibitors; comparison to hMATE1 and rMATE1 PMID: 20067714

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Note=Localized at the brush border membranes of the proximal tubules.
  • 蛋白家族：
    Multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family
  • 組織特異性：
    Isoform 3 is predominantly expressed in kidney. Isoform 6 is expressed in brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26439

    OMIM: 609833

    KEGG: hsa:146802

    STRING: 9606.ENSP00000326671

    UniGene: Hs.126830