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  4. Recombinant Human Putative Polycomb group protein ASXL2 (ASXL2), partial

Recombinant Human Putative Polycomb group protein ASXL2 (ASXL2), partial

  • 中文名稱：
    Recombinant Human Putative Polycomb group protein ASXL2(ASXL2) ,partial,Yeast
  • 貨號：
    CSB-YP765736HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Putative Polycomb group protein ASXL2(ASXL2) ,partial,Yeast
  • 貨號：
    CSB-EP765736HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Putative Polycomb group protein ASXL2(ASXL2) ,partial,Yeast
  • 貨號：
    CSB-EP765736HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Putative Polycomb group protein ASXL2(ASXL2) ,partial,Yeast
  • 貨號：
    CSB-BP765736HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Putative Polycomb group protein ASXL2(ASXL2) ,partial,Yeast
  • 貨號：
    CSB-MP765736HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    additional sex combs like 2 (Drosophila); Additional sex combs like 2; Additional sex combs like protein 2; Additional sex combs-like protein 2; ASXH2; ASXL 2; ASXL2; ASXL2_HUMAN; DKFZp686C1968; FLJ10898; KIAA1685; Polycomb group protein ASXH2; Putative Polycomb group protein ASXL2; SHAPNS
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.
  • 基因功能參考文獻：
    1. ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia. PMID: 28516957
    2. Infrequent occurrence of TET1, TET3, and ASXL2 mutations in myelodysplastic/myeloproliferative neoplasms PMID: 29531217
    3. In the Title. PMID: 28090090
    4. Data indicate higher ASXL2 expression in ERalpha-positive patients, suggesting that ASXL2 could be a prognostic marker in breast cancer. PMID: 26640146
    5. Mutation in ASXL2 is associated with core-binding factor acute myeloid leukemia. PMID: 27798625
    6. ASXL2 mutation is associated with acute myeloid leukemia. PMID: 28063196
    7. de novo truncating variants in ASXL2 underlie a neurodevelopmental syndrome with a clinically recognizable phenotype; this report expands the germline disorders that are linked to the ASXL genes PMID: 27693232
    8. inactivation of the BAP1/ASXL2 axis might contribute to cancer development. PMID: 26416890
    9. ASXL1, ASXL2 and ASXL3 are epigenetic scaffold proteins that are involved in the pathogenesis of non-cancerous diseases and cancers.[Review] PMID: 25835095
    10. identify a high-frequency mutation in t(8;21)/RUNX1-RUNX1T1 acute myekoid leukemia (AML) and identify the need for future studies to investigate the clinical and biological relevance of ASXL2 mutations in this unique subset of AML PMID: 24973361
    11. WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic acid signaling. PMID: 25065743
    12. ASXL1 represses, whereas ASXL2 increases, the expression of adipogenic genes, most of which are PPARgamma targets PMID: 21047783
    13. the apparent occurrence of an unusual TG 3' splice site in intron 2 is discussed PMID: 17672918

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  • 相關(guān)疾?。?/div>
    Shashi-Pena syndrome (SHAPNS)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Asx family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23805

    OMIM: 612991

    KEGG: hsa:55252

    STRING: 9606.ENSP00000391447

    UniGene: Hs.119815