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  4. Recombinant Human Reelin (RELN), partial

Recombinant Human Reelin (RELN), partial

  • 中文名稱：
    人RELN重組蛋白
  • 貨號：
    CSB-BP019557HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RELN重組蛋白
  • 貨號：
    CSB-EP019557HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RELN重組蛋白
  • 貨號：
    CSB-MP019557HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    LIS2; PRO1598; Reeler; Reelin; RELN; RELN_HUMAN; RL
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 表達(dá)區(qū)域：
    26-254aa
  • 氨基酸序列
    AAGYYPRFSPFFFLCTHHGELEGDGEQGEVLISLHIAGNPTYYVPGQEYHVTISTSTFFDGLLVTGLYTSTSVQASQSIGGSSAFGFGIMSDHQFGNQFMCSVVASHVSHLPTTNLSFIWIAPPAGTGCVNFMATATHRGQVIFKDALAQQLCEQGAPTDVTVHPHLAEIHSDSIILRDDFDSYHQLQLNPNIWVECNNCETGEQCGAIMHGNAVTFCEPYGPRELITT
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
  • 基因功能參考文獻(xiàn)：
    1. Study found a positive link between RELN SNP rs2229864 and ASD risk, but not a significant association between RELN SNPs rs736707 and autism risk. A significant rs736707-rs2229864 haplotype was found. Individuals with a CC haplotype were more likely to have autistic spectrum disorders, whereas individuals with a CT haplotype had more possibility to be typical development controls. PMID: 29753726
    2. A two-hit loss involving VHL predicted for clear-cell renal cell carcinoma(ccRCC ) and a better prognosis, whereas mutations in PTEN, TP53, or RELN predicted for Sarcomatoid clear-cell renal cell carcinoma and worse prognosis. PMID: 28710314
    3. we determined that Reelin protein and mRNA levels increased in CJD human samples and in mouse models of human prion disease in contrast to murine models of prion infection. However, changes in Reelin expression appeared only at late terminal stages of the disease, which prevent their use as an efficient diagnostic biomarker. PMID: 27726110
    4. In primary-culture fetal astrocytes, streptozotocin down-regulated the expression of Reelin 410 and 180 kDa , while alpha-boswellic acid upregulated it. Interruption in astroglial Reelin/Akt/Tau signaling pathways may have a role in Alzheimer disease. PMID: 27567921
    5. In frontal cortex extracts, an increase in Reelin mRNA, and in soluble and insoluble (guanidine-extractable) Reelin protein, was associated with late Braak stages of Alzheimer's disease (AD), while expression of its receptor, ApoER2, did not change. PMID: 27531658
    6. This study detected significant reductions in the mRNAs associated with RELN and GAD1 in the frontal cortex (FC) of autism spectrum disorder. PMID: 28229923
    7. There results suggest that reelin played essential roles in the development of lymphoma and might be a potential drug target in lymphoma PMID: 28498462
    8. This review addresses recent advances in the field of nonneuronal reelin signaling. PMID: 27739126
    9. methylation status of the promoter proximal cytosine-phospho-guanine dinucleotides determines the expression of RELN in myeloma cells. PMID: 27245998
    10. Meta-analyses of 12 RELN gene single nucleotide polymorphisms (SNPs) and related neuropsychiatric disorders (schizophrenia, autistic spectrum disorders, attention-deficit hyperactivity disorder, Alzheimer's disease and bipolar disorders) with subgroup analyses based on ethnicity. Findings suggest a role of RELN SNPs in psychiatric diseases. PMID: 28506622
    11. review of role in Alzheimer's disease PMID: 27031488
    12. Significant association between rs17458357 , rs2572683,rs12555895 within the RELN gene and accelerated decline in Cognition performance in Chinese elderly male Gout population. PMID: 28953682
    13. This study demonstrated that RELN DNA methylation might contribute to the pathogenesis of schizophrenia. PMID: 28086126
    14. The present investigation, performed on a study sample from a population with one of the highest suicide rates in the world, indicated an association between rs2965087 in the reelin gene and the expression of suicidal threats a month before suicide in contrast to other symptoms of depression. PMID: 27537376
    15. Reelin is was low in primary breast cancer tissue, but higher in Her2(+) breast cancers (but not triple-negative ones) metastasizing to the brain, especially in the tumor periphery adjacent to surrounding astrocytes. In the neural niche, astrocytes epigenetically regulate Reelin expression and its interaction with Her2 leading to increased proliferation and survival fitness. PMID: 28210910
    16. Heterozygous RELN mutations cause a typical Autosomal Dominant Lateral Temporal Lobe Epilepsy syndrome, indistinguishable from that associated with LGI1 mutations. PMID: 28142128
    17. We screened for mutations in RELN or VLDLR and compared the phenotype of these patients with that of previously reported patients. differences in clinical severity, involvement of the cerebellar hemispheres, together with the severity of the neocortical defect, enables RELN-mutated patients to be distinguished from VLDLR-mutated patients. PMID: 27000652
    18. Reelin signaling is a critical player in the modulation of synaptic function. PMID: 27994051
    19. Reelin was expressed by human hepatic stellate cells/myofibroblasts and the number of these cells increased significantly in the lobule as the liver fibrosis progressed, suggesting a role for Reelin in the activation of hepatic stellate cells/myofibroblasts during liver injury. PMID: 28348420
    20. The presence of reelin was elevated in junctional areas as in dysplastic nevi. VLDLR presented positive values in 16 cases (16/ 32) and ApoER2 was weak positive in 7 cases. PMID: 28255385
    21. common variants of GABRG2, RELN and NRG3 and the GABRG2-RELN-PTCH1 interaction networks might confer altered susceptibility to Hirschsprung disease. PMID: 27889765
    22. RELN is mapped at 7q22, which had been identified as a candidate region for autism by early genetic linkage study. PMID: 26285919
    23. reelin promotes multiple myeloma cell adhesion, survival, and drug resistance via activation of integrin alpha5beta1. PMID: 26848618
    24. These findings suggest that circulating Reelin promotes atherosclerosis by increasing vascular inflammation, and that reducing or inhibiting circulating Reelin may present a novel approach for the prevention of cardiovascular disease. PMID: 26980442
    25. Reelin thus plays a role in restraining RAS and PI3-kinase promotion of cell motility and potentially tumour metastasis. PMID: 27071537
    26. Among men, but not in women certain genotypes of the RELN gene were significantly associated with the susceptibility to Alzheimer's disease. PMID: 26384575
    27. Report demonstrated that the reelin subregion R5-6 consisting of 747 amino acids in the 5th and 6th repeats was sufficient for apoER2 and VLDLR binding, and inhibiting lipoprotein-induced cholesterol accumulation in macrophages. PMID: 26317415
    28. The features of reelin expression in the brain of fetuses and newborns at 22-40 weeks' gestation with internal HC should be considered as morphological differential and diagnostic criteria for the disease in relation to its etiology. PMID: 26978229
    29. Study shows that early neural cells transiently express Reelin at the time they leave the presumptive olfactory/vomeronasal epithelium and that Dab 1 is present in the migratory cell mass and in the presumptive ensheathing cells in the absence of reelin. PMID: 26270645
    30. the reelin protein blood concentration might be a relevant signal with respect to the pathophysiology of schizophrenia. PMID: 26305216
    31. These findings suggest a central AKT-FOXG1-reelin signaling pathway in focal malformations of cortical development and support pathway inhibitors as potential treatments or therapies for some forms of focal epilepsy. PMID: 26523971
    32. rs7341475 (A/G) and rs262355 (A/T) polymorphisms in RELN gene are inversely associated with SZ risk. PMID: 26455866
    33. RELN SNPs were associated with Alzheimer disease and mild cognitive impairment. GG genotype at rs2299356 was associated with risk of AD. RELN-rs528528 CT genotype was protective for MCI. PMID: 24384746
    34. pThis study roposed that RELN mutations contribute to the genetic heterogeneity of myoclonus-dystonia. PMID: 25648840
    35. Heterozygous reelin mutations cause autosomal-dominant lateral temporal epilepsy. PMID: 26046367
    36. serum reelin may be considered an additional useful parameter for monitoring the progression of hepatic fibrosis in HCV-infected patients specially in those with active rheumatological conditions which result in an increase in serum hyaluronic acid PMID: 24803609
    37. RELN expression in the cerebral cortex of subjects with autism is not a consequence of decreased numbers of RELN-expressing neurons PMID: 25067827
    38. RELN gene polymorphism rs7341475 C>T is associated with the risk of paranoid schizophrenia in Russians and Tatars. PMID: 25842846
    39. The results of this study demonstrated the presence of reelin, its receptors VLDLR and ApoER2 as well as Dab1 in the ENS and might indicate a novel role of the reelin system in regulating neuronal plasticity and pre-synaptic functions in the ENS. PMID: 24844606
    40. Results indicate that aging- and disease-associated changes in Reelin levels and proteolytic processing might play a role in the formation of corpora amylacea by altering cytoskeletal dynamics PMID: 24252415
    41. The g.504742G>A polymorphic variant in the RELN gene might affect subjects susceptibility toward autism in Chinese Han population. PMID: 23287318
    42. Lack of association for RELN is that RELN could be associated with a specific otosclerosis-like phenotype that is different from the histologically confirmed phenotype of the patients in this study. PMID: 24643032
    43. In this population, the pathogenic link between the rs39335 variant and otosclerosis was excluded. PMID: 24227897
    44. Data indicate taht reelin interacts with amyloid beta-protein(1-42) and is sequestered by fibrils. PMID: 24599114
    45. the RELN rs362691, rather than rs736707 or GGC repeat variant, might contribute significantly to Autism spectrum disorder risk PMID: 24453138
    46. Data suggest that PS1/gamma-secretase-dependent processing of the reelin receptor ApoER2 inhibits reelin expression and may regulate its signaling. PMID: 24344333
    47. reelin expression is altered by Abeta leading to impaired reelin signaling. PMID: 23951306
    48. In this review, the signaling protein Reelin, expressed along olfactory and limbic pathways is involved in the early stages of Alzheimer's disease. PMID: 23632168
    49. Data indicate that Reelin is up-regulated during erythroid differentiation of erythroleukemic K562 cells. PMID: 24239537
    50. moderate risk of bias show a statistically significant association with the ACE gene, AGT gene, OTSC2, RELN gene, TGFB1 gene, 11q13.1, OTSC2, OTSC5, OTSC8, and OTSC10. [Review] PMID: 24170657

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  • 相關(guān)疾病：
    Lissencephaly 2 (LIS2); Epilepsy, familial temporal lobe, 7 (ETL7)
  • 亞細(xì)胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Reelin family
  • 組織特異性：
    Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9957

    OMIM: 257320

    KEGG: hsa:5649

    STRING: 9606.ENSP00000392423

    UniGene: Hs.655654