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  4. Recombinant Human Regenerating islet-derived protein 4 (REG4)

Recombinant Human Regenerating islet-derived protein 4 (REG4)

  • 中文名稱：
    人REG4重組蛋白
  • 貨號：
    CSB-YP887169HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人REG4重組蛋白
  • 貨號：
    CSB-EP887169HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人REG4重組蛋白
  • 貨號：
    CSB-EP887169HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人REG4重組蛋白
  • 貨號：
    CSB-BP887169HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人REG4重組蛋白
  • 貨號：
    CSB-MP887169HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    REG4
  • Uniprot No.：
  • 別名：
    Gastrointestinal secretory protein; GISP; Reg IV; REG like protein; REG-4; REG-like protein; Reg4; REG4_HUMAN; Regenerating gene type IV; Regenerating islet derived family member 4; Regenerating islet derived protein 4 precursor; Regenerating islet-derived protein 4; Regenerating islet-derived protein IV; REGIV; RELP
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    23-158
  • 氨基酸序列
    DIIMRPSC APGWFYHKSN CYGYFRKLRN WSDAELECQS YGNGAHLASI LSLKEASTIA EYISGYQRSQ PIWIGLHDPQ KRQQWQWIDG AMYLYRSWSG KSMGGNKHCA EMSSNNNFLT WSSNECNKRQ HFLCKYRP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.
  • 基因功能參考文獻：
    1. Our study demonstrated that Reg IV positively regulates the expression of SOX9 and is involved in tumor cell invasion and migration in gastric cancer. PMID: 29587675
    2. Reg4 inhibited apoptosis through regulating MAPK/Erk/Bim signaling pathway and thereby enhanced the resistance of gastric cancer to 5-Fluorouracil. PMID: 28759561
    3. Data indicate that REG4 tissue expression is a prognostic marker in subgroups of pancreatic ductal adenocarcinoma patients, and Serum REG4 level might be useful in differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis. PMID: 29542402
    4. REG4 promotes peritoneal metastasis of gastric cancer through GPR37 and triggers a positive feedback loop. PMID: 27036049
    5. Study demonstrated that REG4, which is overexpressed in pancreatic ductal adenocarcinoma and secreted by cancer cells, promoted macrophage polarization to M2, through at least in part, activation of ERK1/2 and CREB. PMID: 26531138
    6. REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis. PMID: 26387746
    7. This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for follow-up of patients with mucinous ovarian cancer. PMID: 26981633
    8. aberrant REG4 expression plays an essential role in early ovarian carcinogenesis and is closely linked to mucinous ovarian tumors, differentiation and adverse prognosis of ovarian cancer by modulating proliferation, apoptosis, migration and invasion. PMID: 26077911
    9. REG4 expression associated with favorable clinicopathological parameters and with higher overall survival from non-mucinous PMID: 25295732
    10. The Reg IV may be involved in the finetuning of functions exerted by the neuroendocrine cells in the GI-tract. PMID: 23499801
    11. Colorectal tumor patients with Reg4- and MMP-7-positive tumors had extremely poor overall survival. PMID: 25338725
    12. High expression of REG4 is associated with poor therapeutic response, adverse outcome and an aggressive phenotype in rectal cancer patients treated with neoadjuvant chemoradiotherapy. PMID: 25155043
    13. miR-24 functions as a novel tumor suppressor in gastric cancer, and the anti-oncogenic activity may involve its inhibition of the target gene REG4. PMID: 24886316
    14. REG4 expression is common in mucinous borderline ovarian tumors of the intestinal type as it is absent in the endocervical-like form tumors. PMID: 23958547
    15. the combination of VEGF-C and Reg IV may be a promising factor for clinical staging to supplement the classical TNM classification system. PMID: 24101199
    16. the stemness properties of control mammospheres and RegIV knockdown mammospheres were compared by tumourigenicity assay in vivo and plate colony formation assay in vitro. PMID: 24064664
    17. Reg4-induced mitogenesis involves Akt-GSK3beta-beta-Catenin-TCF-4 signaling in human colorectal cancer. PMID: 24151146
    18. Immunohistochemistry against known cell-type markers on serial sections has localised the expression of REGs to metaplastic Paneth cells (REG1A, REG1B and REG3A) and enteroendocrine cells (REG4), with a marked expansion of expression during inflammation. PMID: 23519454
    19. CDX2 protein directly regulates Reg IV expression in gastric cancer PMID: 23133598
    20. RegIV may play an important role in the intrinsic resistance of gastric cancer cells to 5-FU. PMID: 23010741
    21. Suggest that Reg IV might accelerate disease progression and act as a candidate prognostic marker for gliomas. PMID: 22713481
    22. REG4 promotes not only growth but also in vitro invasiveness of pancreatic cancer cells by upregulating MMP-7 and MMP-9. PMID: 22957785
    23. TGF-beta signalling reduces the expression of ALDH1 and REG4, and the size of the ALDH1+ cell population. PMID: 22430847
    24. Knockdown of Reg IV impacted the ability of insulin and EGF to stimulate downstream tyrosine phosphorylation. PMID: 21445968
    25. REG4, BIRC5 and NEIL2 genes might have a role in the sensitivity of cancer patients to radiotherapy PMID: 22199273
    26. Overexpression of REGIV mRNA is assessed with peritoneal recurrence in gastric adenocarcinoma. PMID: 21780125
    27. REG4 may be a prognostic indicator and a better serum marker than carcinoembryonic antigen and carbohydrate antigen 19-9 for early diagnosis of gastric cancer. PMID: 21419474
    28. GLI1 promotes RegIV transcription by binding to the RegIV gene promoter in pancreatic cancer. PMID: 21494603
    29. The solution structure of hRegIV-P91S was determined, showing that it adopts a typical fold of C-type lectin. Based on the chemical shift perturbations of amide resonances, two calcium-independent mannan-binding sites were proposed PMID: 20692269
    30. REG4 may play an important role in the development and progression of colorectal cancer, as well as in intestinal morphogenesis and epithelium restitution PMID: 20126989
    31. RegIV is expressed in the gastrointestinal tract and in digestive tract neuroendocrine tumor PMID: 20349522
    32. REG IV overexpression may be an early event in colorectal carcinoma carcinogenesis. PMID: 20183800
    33. RegIV enhances LoVo cell migration and invasion, and its CRD domain is critical for these effects. PMID: 20417867
    34. REG4 is expressed in pancreatic cancer, and serum levels of REG4 offer a useful indicator for distinguishing between patients with pancreatic cancer and healthy subjects PMID: 19789838
    35. Reg IV as an important modulator of gastrointestinal cell susceptibility to irradiation; hence, it is a potential target for adjunctive treatments for human colorectal cancer and other gastrointestinal malignancies. PMID: 19900450
    36. reg4 is amplified in the early stages of pancreatic cancer development PMID: 19834624
    37. Data demonstrated in vitro and in vivo that REG4 protein overexpression was associated with an unfavorable response to preoperative chemoradiotherapy. PMID: 19546835
    38. Local Reg IV expression may be influenced by the growth factors basic fibroblast growth factor and somatotropin and dtheri receptors PMID: 19924642
    39. Results suggest that RELP might be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. PMID: 12819006
    40. overexpression of Reg IV may be an early event in colorectal carcinogenesis. PMID: 14550954
    41. Increased expression of Reg IV is associated wirh hormone refractory metastatic prostate cancer PMID: 15788672
    42. RELP serves as a marker for appendiceal mucinous cystadenomas and pseudomyxoma peritonei and may contribute to the pathogenesis of these disorders. PMID: 16323007
    43. Reg IV is a potent activator of the EGF receptor/Akt/AP-1 signaling pathway in colorectal carcinoma PMID: 16401477
    44. Overexpression of REG4 is associated with pancreatic cancer PMID: 16918991
    45. serum Reg IV concentration may predict metastatic recurrence of colorectal cancer in the liver.Reg IV protein expression induced by growth factors may function as a growth-promoting and/or an antiapoptotic factor in the peritumoral mucosa of CRC. PMID: 18187959
    46. RegIV expression was markedly higher in gastric cancer patients with peritoneal metastases compared to those without; level of RegIV mRNA in gastric cancer patients was related to the extent of wall penetration PMID: 18505053
    47. Reg IV staining can aid in diagnosis of gastrointestinal signet ring cell carcinoma. PMID: 18580680
    48. These results suggest that Reg IV expression is an independent prognostic indicator of relapse after radical prostatectomy. PMID: 18754868
    49. Reg IV might accelerate cell growth and disease progression of adenoid cystic carcinomas . PMID: 19076683
    50. among major urologic cancers, Reg IV is expressed frequently in prostate cancer, and that serum Reg IV represents a novel biomarker for prostate cancer PMID: 19082448

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  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in
  • 數(shù)據(jù)庫鏈接：

    HGNC: 22977

    OMIM: 609846

    KEGG: hsa:83998

    STRING: 9606.ENSP00000256585

    UniGene: Hs.660883