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Recombinant Human Renin (REN)

  • 中文名稱：
    人REN重組蛋白
  • 貨號(hào)：
    CSB-YP019561HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人REN重組蛋白
  • 貨號(hào)：
    CSB-EP019561HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人REN重組蛋白
  • 貨號(hào)：
    CSB-EP019561HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人REN重組蛋白
  • 貨號(hào)：
    CSB-BP019561HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人REN重組蛋白
  • 貨號(hào)：
    CSB-MP019561HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Angiotensin forming enzyme; Angiotensin forming enzyme precursor ; Angiotensinogenase; Angiotensinogenase precursor; FLJ10761; HNFJ2; REN; Ren1; RENI_HUMAN; Renin; Renin precursor renal
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    67-406
  • 氨基酸序列
    LTLG NTTSSVILTN YMDTQYYGEI GIGTPPQTFK VVFDTGSSNV WVPSSKCSRL YTACVYHKLF DASDSSSYKH NGTELTLRYS TGTVSGFLSQ DIITVGGITV TQMFGEVTEM PALPFMLAEF DGVVGMGFIE QAIGRVTPIF DNIISQGVLK EDVFSFYYNR DSENSQSLGG QIVLGGSDPQ HYEGNFHYIN LIKTGVWQIQ MKGVSVGSST LLCEDGCLAL VDTGASYISG STSSIEKLME ALGAKKRLFD YVVKCNEGPT LPDISFHLGG KEYTLTSADY VFQESYSSKK LCTLAIHAMD IPPPTGPTWA LGATFIRKFY TEFDRRNNRI GFALAR
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
  • 基因功能參考文獻(xiàn)：
    1. Mean blood pressure, plasma Ang II level, and myocardium malondialdehyde (MDA) content of angiotensinogen-renin (AGT-REN) double transgenic hypertension (dTH) mice were higher than those in wild-type (WT) mice. PMID: 28455747
    2. This study reveals that the human renin protein is able to complement the mouse Ren1d(-/-) non-granulated defect and suggests that granulopoiesis requires a structural motif that is conserved between the mouse Ren1d and human renin proteins. PMID: 29123029
    3. Findings suggest the prorenin binding to (pro)renin receptor involvement of receptor-associated prorenin system (RAPS) in the pathogenesis of idiopathic epiretinal membrane (iERM). PMID: 28276504
    4. The current study provides evidence for a possible association of renin gene polymorphisms with essential hypertension in a Han population of northern China. PMID: 29233044
    5. Plasma renin activity is associated with cardiovascular mortality or heart failure readmissions. PMID: 28875746
    6. In patients with established atherosclerotic disease undergoing carotid endarterectomy, plasma renin and aldosterone concentrations were not associated with atherosclerotic plaque characteristics. Plasma renin concentration was positively associated with the occurrence of major secondary vascular events. PMID: 29548814
    7. These observations demonstrate that activation of the renin-angiotensin system (RAS) promotes colitis in a blood pressure independent manner. Angiotensin II appears to drive colonic mucosal inflammation by promoting intestinal epithelial cell apoptosis and mucosal TH17 responses in colitis development PMID: 27271344
    8. The genotypes of REN, AT1R and AT2R were not associated with the development of preeclampsia in South African Black women. PMID: 28641212
    9. Urinary angiotensinogen and renin excretion are elevated in CKD patients. Both parameters are negatively associated with eGFR and these associations are independent of urinary albumin excretion PMID: 28395289
    10. Autosomal dominant polycystic kidney disease (ADPKD), uniquely increases urinary angiotensinogen and renin excretion despite their circulating levels being comparable with those in non-ADPKD chronic kidney disease. PMID: 28747358
    11. Prospective study of consecutive cardiac disease patients referred for cardiac catheterization has revealed distinct cardiac disease condition-associated differences in the frequencies of elevations in plasma renin, plasma aldosterone concentration, and the aldosterone-renin ratio PMID: 28640140
    12. Renin-angiotensin system transgenic mouse model suggests that renal injury in preeclampsia may be mediated through local VEGF. PMID: 27927648
    13. Data suggest mild primary aldosteronism (PA), where plasma renin activity is not as suppressed, is susceptible to dietary sodium influences on renin and ARR (aldosterone to renin ratio). Optimal screening for PA should occur under conditions of high dietary sodium intake (rather than condition of low dietary sodium intake as frequently prescribed for patients with hypertension, which may be a symptom of PA). PMID: 27428770
    14. Allelic frequency of A of SNP 12109G>A was higher in women with preterm birth than in women with normal vaginal delivery and could be considered a risk factor. PMID: 28019132
    15. This study demonstrates the efficacy of aldosterone/direct renin concentration ratio as a screening test for primary aldosteronism. PMID: 27534428
    16. The dominant model (CC vs. CT+TT) of rs1894111 polymorphism in the ADRBK1 gene might be associated with low-renin hypertension in Han Chinese. PMID: 27555048
    17. Data show that the optimum time for beta-adrenoreceptor antagonists (beta-blockers) withdrawal was 2 weeks when using direct renin concentration (DRC) and 3 weeks for plasma renin activity (PRA). PMID: 26300226
    18. Active renin was not significantly different between hypertensive patients with and without left ventricular hypertrophy. PMID: 26163660
    19. The present study provides evidence that the rs1464816 polymorphism in REN is associated with CKD progression in ADPKD. PMID: 26753721
    20. Plasma renin and Aldosterone to renin ratio but not aldosterone are independently associated with presence of carotid plaques in coronary artery disease patients. PMID: 25237165
    21. concentrations of serum aldosterone, plasma direct renin, and plasma renin activity were measured after a night's rest and again after walking for two hours. PMID: 25143328
    22. Increased plasma renin, AT and VEGF might play a role in the onset or development of superficial infantile hemangiomas. PMID: 26489635
    23. Elevated levels of circulating (pro)renin were observed in pre-eclampsia patients PMID: 25767135
    24. The results suggest that variants in the enhancer region of the human renin gene have an effect on the expression levels of renin in renal tissue; this observation is in good accordance with the results of the transcriptional assay. PMID: 26366736
    25. Aliskiren prevents renal disease progression by suppressing both angiotensin I and II in human renin angiotensinogen transgenic mice with high salt loading. PMID: 24154707
    26. Primary aldosteronism seems associated with a lower level of prorenin than essential hypertension PMID: 25333683
    27. Demonstrate that there are strong interactions between prorenin, ATP6AP2, and TGFB1 and that this system has a greater capacity in female amnion to stimulate profibrotic pathways, thus maintaining the integrity of the fetal membranes. PMID: 25491485
    28. the aldosterone-renin ratio may have role in total and cancer death in Japanese individuals PMID: 25279703
    29. We conclude that heterozygous substitutions at AGT and REN loci correlate significantly with end-stage renal disease in a north Indian population PMID: 25660845
    30. Salt supplementation blunts the telmisartan induced increase in plasma renin activity in patients with type 2 diabetes. PMID: 25849646
    31. our data suggest that the renin polymorphism plays an important role in the risk of developing coronary artery disease with the highest risk for C allele, but do not support its role as a risk factor for developing restenosis after coronary stenting PMID: 26102248
    32. This study showed no involvement of A/G renin polymorphisms in the pathogenesis of heart failure. PMID: 26076559
    33. the A allele of rs6682082 of renin is a positive genetic marker for predisposition to essential hypertension and high blood pressure in Korean women. PMID: 25510769
    34. Data show that administration of bone-marrow-derived stromal cells (BMSCs) with human transgenic angiotensinogen and renin genes in the mouse acute kidney injury (AKI) model resulted in exacerbation of kidney injury. PMID: 25534858
    35. Urinary renin levels should be measured by established renin assays. PMID: 24742480
    36. Report ethnic differences in association of plasma renin levels with blood pressure. PMID: 24436325
    37. We sho a gender-dependent association of the renin rs6693954 SNP with central and ambulatory BP in patients with type 2 diabetes mellitus. PMID: 23358739
    38. Activation of the renin-angiotensin system in the subfornical organ is sufficient to mediate an increase in drinking through PKC pathway. PMID: 24965793
    39. Data suggest that the renin-angiotensin system plays a critical role in placentation and nephrogenesis. PMID: 24164175
    40. These data suggest the importance of the activated oxidative stress/AGT/RAS axis in the pathogenesis of diabetic nephropathy. PMID: 24284398
    41. renin gene Mbo I site polymorphism is not associated with blood pressure levels and risk of hypertension. PMID: 23108193
    42. The levels of circulating and local renin-angiotensin-aldosterone system expressions were different in atrial fibrillation patients with different types of mitral valvular diseases. PMID: 23077077
    43. Plasma renin activity identifies a group of high risk patients for heart failure in patients with chronic kidney disease. PMID: 22459392
    44. Plasma sPRR concentrations are dependent on ethnicity and independent of renin, prorenin, and aldosterone concentrations in healthy subjects and in patients with contrasted degrees of renin-angiotensin system activity. PMID: 24218434
    45. the main site of renin in the end-stage kidney is the juxtaglomerular cells. PMID: 23292178
    46. No significant differences in plasma renin activity are found between patients with polycystic ovary syndrome and controls. PMID: 23461768
    47. Aldosterone rise that often occurs during prolonged renin-angiotensin system blockade is rather due to the angiotensin II 'escape' during such blockade. PMID: 22396488
    48. These in vitro data indicate that prorenin acidified in vivo possibly modulate renin angiotensin system in (pro)renin receptor-dependent and/or -independent manners which could ultimately lead to the pathogenesis of diseases. PMID: 23111329
    49. in twin pregnancies, relative to singleton pregnancies, second trimester plasma level elevated and third trimester level reduced PMID: 22676457
    50. We observed a disproportionately high level of prorenin in blacks. These high circulating prorenin levels however do not result in greater adrenal angiotensin II and aldosterone production in healthy young blacks. PMID: 22695510

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  • 相關(guān)疾?。?/div>
    Renal tubular dysgenesis (RTD); Familial juvenile hyperuricemic nephropathy 2 (HNFJ2)
  • 亞細(xì)胞定位：
    Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.
  • 蛋白家族：
    Peptidase A1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9958

    OMIM: 179820

    KEGG: hsa:5972

    STRING: 9606.ENSP00000272190

    UniGene: Hs.3210