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  4. Recombinant Human Rho GTPase-activating protein 5 (ARHGAP5), partial

Recombinant Human Rho GTPase-activating protein 5 (ARHGAP5), partial

  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 5(ARHGAP5) ,partial,Yeast
  • 貨號：
    CSB-YP622633HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 5(ARHGAP5) ,partial,Yeast
  • 貨號：
    CSB-EP622633HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 5(ARHGAP5) ,partial,Yeast
  • 貨號：
    CSB-EP622633HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 5(ARHGAP5) ,partial,Yeast
  • 貨號：
    CSB-BP622633HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Rho GTPase-activating protein 5(ARHGAP5) ,partial,Yeast
  • 貨號：
    CSB-MP622633HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Arhgap5; p190-B; RHG05_HUMAN; Rho GTPase activating protein 5; Rho GTPase-activating protein 5; Rho-type GTPase-activating protein 5
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    GTPase-activating protein for Rho family members.
  • 基因功能參考文獻：
    1. only collagen-IV elicits the formation of proteolytically active podosomes through a mechanism involving increased Src phosphorylation, p190RhoGAP-B (also known as ARHGAP5) relocalisation and MT1-MMP (also known as MMP14) cell surface exposure at podosome sites. PMID: 27231093
    2. Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison. PMID: 28100790
    3. This newly identified miR-744/ARHGAP5 pathway provides further insight into the progression and metastasis of NPC and indicates potential novel therapeutic targets for NPC. PMID: 25961434
    4. Ectopic expression of p190B suppressed the miR-494-induced EGFR upregulation. PMID: 24316134
    5. The expression level of miR-486-5p was inversely correlated with that of ARHGAP5. PMID: 23474761
    6. RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis. PMID: 23552690
    7. Data indicate a role for p120-catenin (amino acids 820-843) domain in the p120-catenin.p190RhoGAP signaling complex assembly and membrane targeting. PMID: 23653363
    8. A cell cycle-regulated reduction in endogenous p190 levels is linked to completion of cytokinesis and generation of viable cell progeny. PMID: 14610059
    9. precise control of p190-B Rho GTPase-activating protein activity is critical for normal branching morphogenesis during mammary gland development PMID: 16469769
    10. Results link Cdk5 to Rho-ROCK signaling via Src and p190RhoGAP and implicate Cdk5 in the regulation of cell contraction, attachment, and migration. PMID: 19822667

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 組織特異性：
    Detected in skin fibroblasts (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 675

    OMIM: 602680

    KEGG: hsa:394

    STRING: 9606.ENSP00000371897

    UniGene: Hs.592313