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Recombinant Human Sal-like protein 2 (SALL2), partial

  • 中文名稱：
    人SALL2重組蛋白
  • 貨號(hào)：
    CSB-MP896719HU
  • 規(guī)格：
    ￥2640
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    SALL2
  • Uniprot No.：
  • 別名：
    SALL2; KIAA0360; SAL2; ZNF795; Sal-like protein 2; Zinc finger protein 795; Zinc finger protein SALL2; Zinc finger protein Spalt-2; Sal-2; hSal2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    Mammalian cell
  • 分子量：
    25.3 kDa
  • 表達(dá)區(qū)域：
    1-198aa
  • 氨基酸序列
    MSRRKQRKPQQLISDCEGPSASENGDASEEDHPQVCAKCCAQFTDPTEFLAHQNACSTDPPVMVIIGGQENPNNSSASSEPRPEGHNNPQVMDTEHSNPPDSGSSVPTDPTWGPERRGEESPGHFLVAATGTAAGGGGGLILASPKLGATPLPPESTPAPPPPPPPPPPPGVGSGHLNIPLILEELRVLQQRQIHQMQ
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal Flag-Myc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure.
  • 基因功能參考文獻(xiàn)：
    1. Sall2 may play a significant role in NIT-1 cell function. PMID: 29783189
    2. Using RNA interference, the role of Spalt-like gene-2 (SALL2) was investigated in human ovarian carcinoma (OC) A2780 cells. Found downregulation of SALL2 promoted growth of the OC cell line. PMID: 29228922
    3. Understanding SALL2 function and the molecular mechanisms governing its expression and activity is critical to comprehend why and how SALL2 could contribute to disease. This knowledge will open new perspectives for the development of molecular targeted approaches in disease PMID: 28430874
    4. Sall2 enhanced the p16 minigene blocking of cell cycle progression and p16 knockdown with siRNA abolished most of the Sall2 inhibition of cell cycle progression PMID: 25580951
    5. Mechanisms of silencing SALL2 in OVCA cell lines and primary tumors and possible therapeutic approaches for ovarian carcinoma are discussed in this review. PMID: 25608837
    6. A role for SALL2 in eye morphogenesis and loss of function of the gene causes ocular coloboma in humans and mice. PMID: 24412933
    7. The SALL2 P2 promoter is hypermethylated in a majority of serous ovarian carcinomas. PMID: 23273547
    8. c-MYC may come under negative regulation by p150, consistent with the action of p150 as a putative tumor suppressor. PMID: 23029531
    9. Here, the authors report that human papillomavirus type 16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1) transcription. PMID: 21791360
    10. Results demonstrate binding of p150(Sal2) to two natural promoters with GC elements related to the optimal binding sequence defined in vitro and whose regulation is important for suppression of tumor growth. PMID: 21362508
    11. A CUL4/DDB1 E3 ligase containing RBBP7 as the p150(Sal2) receptor has been identified as mediating the destruction of p150(Sal2) as cells transition from a quiescent to an actively growing state. PMID: 21228219
    12. Studies indicate that vertebrate sal orthologues (spalt-like/sall) have important developmental roles during neural development and organogenesis and gentic diseases. PMID: 19247946
    13. Epidermal growth factor receptor (a potential therapeutic target) and SALL2 stained most cases of synovial sarcoma; staining was significantly less common among other tested sarcomas. PMID: 14507652
    14. Results suggest that p150(Sal2), acting in part as a p53-independent regulator of p21 and BAX, can function in some cell types as a regulator of cell growth and survival [p150(Sal2)] PMID: 15082782
    15. These data establish Sall2 as a link between p75 neurotrophin receptor and transcriptional events that regulate the growth and development of neuronal cells. PMID: 19131967

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  • 相關(guān)疾?。?/div>
    Coloboma, ocular, autosomal recessive (COAR)
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Sal C2H2-type zinc-finger protein family
  • 組織特異性：
    Highest levels in adult brain (in different areas). Lower levels in heart; very low levels in kidney and pancreas. Expressed throughout the retina and lens vesicle as well as the periocular mesenchyme.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10526

    OMIM: 216820

    KEGG: hsa:6297

    STRING: 9606.ENSP00000333537

    UniGene: Hs.416358