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  4. Recombinant Human Septin-7 (SEPT7)

Recombinant Human Septin-7 (SEPT7)

  • 中文名稱：
    人SEPT7重組蛋白
  • 貨號：
    CSB-YP620952HU
  • 規(guī)格：
    ￥1500
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    SEPT7
  • Uniprot No.：
  • 別名：
    CDC10; CDC10 protein homolog; CDC3; Cell division cycle 10; NBLA02942; SEPT7; SEPT7_HUMAN; SEPT7A; Septin 7; Septin-7
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    Yeast
  • 分子量：
    52.5kDa
  • 表達區(qū)域：
    2-437aa
  • 氨基酸序列
    SVSARSAAAEERSVNSSTMVAQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEHKIKIYEFPETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKSPLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEDEKANWEAQQRILEQQNSSRTLEKNKKKGKIF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標簽：
    N-terminal 6xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation.
  • 基因功能參考文獻：
    1. The present study identified that SEPT7 was a potential target of miR5903p and demonstrated that SEPT7 is associated with mediating the proapoptotic effect of miR5903p in human osteoblast cell line hFOB 1.19. PMID: 29568931
    2. SEPT7 overexpression and knockdown sept7 protein suppress the expression of 78 kDa glucoseregulated protein (GRP78), C/EBPhomologous protein (CHOP), pro-caspase3 and cleaved caspase3 and eIf 2alpha protein. PMID: 29344665
    3. Study discloses both SEPT2 and SEPT7 are essential for breast cancer cell migration and invasion by controlling MEK/ERK MAPKs activation. PMID: 27557506
    4. SUMOylation of human septins is critical for septin filament bundling and cytokinesis. PMID: 29051266
    5. Low SEPT7 expression is associated with glioma cell invasion. PMID: 27006177
    6. The results of this study found that bipolar Neural crest cells progenitors lose their polarity, retracting their processes to round for division, but generate neurons with bipolar morphology by emitting processes from the same locations as the progenitor. PMID: 28817802
    7. Results show that SEPT7 is involved in glioma cell migration with the assistance of cofilin phosphomediated cytoskeleton locomotion. PMID: 26846171
    8. Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis PMID: 25380047
    9. Significantly lower SEPT7 expression in all expressional categories in encapsulated papillary thyroid carcinoma, follicular variant group may be a sign of different molecular signature in this type of tissue. PMID: 24685401
    10. In response to Candida albicans infection, SEPT7 forms a complex with endothelial cell N-cadherin, is required for normal accumulation of N-cadherin around hyphae, and is necessary for maximal fungal endocytosis. PMID: 24345743
    11. Significantly lower SEPT7 expression in encapsulated follicular variant of papillary thyroid carcinoma may be a sign of different molecular signature in this type of tissue. PMID: 24685401
    12. SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9. PMID: 23572511
    13. miR-30a-5p is a bona fide negative regulator of SEPT7 and the oncogenic activity of miR-30a-5p in human gliomas is at least in part through the repression of SEPT7 PMID: 23383034
    14. Myeloid K562 cells express three SEPT9 isoforms, all of which have an equal propensity to hetero-oligomerize with SEPT7-containing hexamers to generate octameric heteromers. PMID: 22956766
    15. Mutagenic analyses revealed that mutation of a potential phosphorylation site in SEPT7 (Y318) regulates the interaction with other septins. PMID: 21767235
    16. the purification, crystallization and structure for the GTP-binding domain of human septin 7 PMID: 22064074
    17. Sept7 occupies the ends of hexameric building blocks which assemble into non-polarised filaments. PMID: 21824007
    18. The SEPT7 provides the directional guidance cues necessary for polarizing the epithelial microtubule network. PMID: 21788367
    19. Data show that Septins of the SEPT6 group preferentially interacted with septins of the SEPT2 group, SEPT3 group and SEPT7 group. PMID: 21082023
    20. SEPT7 gene expression is decreased in follicular variant of papillary thyroid carcinoma. PMID: 21509594
    21. SEPT7 is involved in the regulation of sperm maturation. PMID: 20352323
    22. The expression of SEPT7 mRNA was significantly decreased by 6.9% in subjects with schizophrenia. PMID: 20385374
    23. This study demonstrates that SEPT7 is involved in gliomagenesis and suppresses glioma cell growth. PMID: 20035367
    24. SEPT7 plays an important role in the glioma cell invasion. PMID: 19916744
    25. regulated but the expression of CDK9, CDC20 and CLK3 was down- regulated in azoospermic testes. PMID: 19426592
    26. Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption PMID: 15485874
    27. septin 2, 6, and 7 complexes make up polymerized filaments PMID: 16914550
    28. crystal structures of the human SEPT2 G domain and the heterotrimeric human SEPT2-SEPT6-SEPT7 complex PMID: 17637674
    29. Demonstrate connection between septins/SOCS7/NCK signaling and the DNA damage response. PMID: 17803907
    30. SEPT7 forms a link between kinetochore distribution of CENP-E and the mitotic spindle checkpoint. PMID: 18460473
    31. SEPT7 gene can inhibit the invasion and migration ability of U251 glioma cells by reversing imbalanced state of MMPs/TIMPs, downregulating expression of integrin alpha(v)beta(3) and altering structure of tubulin-alpha. PMID: 18543212

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  • 亞細胞定位：
    Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum.
  • 蛋白家族：
    TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 1717

    OMIM: 603151

    KEGG: hsa:989

    STRING: 9606.ENSP00000381992

    UniGene: Hs.191346