Recombinant Human Thyroid hormone receptor alpha (THRA)
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中文名稱:人THRA重組蛋白
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貨號:CSB-YP023510HU
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規(guī)格:
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來源:
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其他:
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中文名稱:人THRA重組蛋白
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貨號:CSB-EP023510HU-B
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規(guī)格:
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來源:E.coli
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共軛:Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他:
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中文名稱:人THRA重組蛋白
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貨號:CSB-BP023510HU
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規(guī)格:
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來源:Baculovirus
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其他:
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中文名稱:人THRA重組蛋白
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貨號:CSB-MP023510HU
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規(guī)格:
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來源:Mammalian cell
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其他:
產(chǎn)品詳情
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純度:>85% (SDS-PAGE)
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基因名:THRA
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Uniprot No.:
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別名:c-erbA-1; C-erbA-alpha; EAR-7; ERBA 1; ERBA; ERBA related 7; Nuclear receptor subfamily 1 group A member 1; THA_HUMAN; THRA; Thra1; Thra2; Thyroid hormone receptor alpha 1; Thyroid hormone receptor alpha 2; Thyroid hormone receptor alpha; TR alpha 1; TR alpha 2; Tra1; Triiodothyronine receptor; V-erbA-related protein 7
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種屬:Homo sapiens (Human)
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蛋白長度:Full length protein
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表達區(qū)域:1-490
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氨基酸序列MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCSLKTSMS GYIPSYLDKD EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM IRSLQQRPEP TPEEWDLIHI ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ QLLGMHVVQG PQVRQLEQQL GEAGSLQGPV LQHQSPKSPQ QRLLELLHRS GILHARAVCG EDDSSEADSP SSSEEEPEVC EDLAGNAASP
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蛋白標(biāo)簽:Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產(chǎn)品提供形式:Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復(fù)溶:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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貨期:Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet :Please contact us to get it.
相關(guān)產(chǎn)品
靶點詳情
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功能:Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.; Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
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基因功能參考文獻:
- Thyroid receptors (TRalpha and TRbeta) are major components of the thyroid hormone pathway which is linked to neuronal development. PMID: 28856816
- overview of the clinical features together with the underlying molecular mechanisms in patients with resistance to thyroid hormone due to heterozygous mutations in TRalpha (Review). PMID: 28527577
- We found that the thyroid hormone receptor (TRalpha 3) has a differential expression profile. Thyroid hormone is critical for normal brain development. Our results showed that there is a possible link between IGF1/IGF1R and the TRalpha 3 and that over expression of IGF1R in RTT cells may be the cause of neurites improvement in neural RTT-derived neurons. PMID: 28007906
- This large case series underlines the variation in the clinical phenotype of RTHalpha patients. PMID: 27144938
- THRA predominates in multipotent human adipose derived stem cells (hADSC) whereas THRB is expressed at lower levels and is upregulated during hADSC differentiation. PMID: 27732649
- The expression of thyroid receptor alpha is linked to fertility status. PMID: 26715425
- 8 different THRA gene abnormalities have been described in 14 patients from 9 families with phenotypes including short stature, dysmorphic syndrome, psychoneuromotor disorders, constipation and bradycardia. Review. PMID: 26585273
- The current study aimed to investigate whether TRs may be specifically expressed in BRCA1 associated cancer cases. PMID: 26029931
- THRA mutations may be more common than expected. In patients with clinical symptoms of mild hypothyreosis without confirmation in endocrine studies, a molecular study of THRA defects is strongly recommended. PMID: 25670821
- Thyroid hormone receptor (TRalpha1) is shown to occur and determine postischemic remodeling and cardiac recovery depending on the availability of TH. [review] PMID: 25501869
- Data suggest thyroid hormone resistance syndrome can be exhibited by patients with heterozygous missense mutation (Ala263Val) in THRA1 and THRA2, isoforms resulting from alternative splicing. [CASE REPORT] PMID: 24969835
- THRalpha rs939348 polymorphism was associated with L-T4 dose and central obesity among hypothyroid patients. PMID: 25079464
- Thyroid hormone signalling may be important in a proportion of breast cancers and THRalpha2 expression may be a regulator of signalling in this pathway. PMID: 25542270
- substantial reduction in the protein expression profile of THRs in malignant versus nonmalignant mammary epithelium suggesting a possible role in breast cancer development. PMID: 24162265
- A new x-ray crystallographic structure of thyroid hormone receptor ligand-binding domains shows a second binding site for thyroid hormones. PMID: 24552590
- Transactivation of reporter genes in response to T4 thyroid hormone was dependent on the thyroid hormone receptor subtypes in human cells. PMID: 24673558
- Thyroid hormone receptor alpha mutation is associated with a severe and thyroxine-resistant skeletal dysplasia. PMID: 24914936
- TRalpha1 and TRbeta1, preferentially partner with distinct panels of auxiliary proteins. PMID: 24325866
- THRA gene polymorphisms are associated with obesity development. This is a novel observation linking the THRA locus to metabolic phenotypes. PMID: 23399772
- Mutations affecting THRA are not a common cause of high BMD in healthy euthyroid post-menopausal women. PMID: 24480136
- Adult female with defective TRalpha defines a shared phenotype in TRalpha-mediated resistance to thyroid hormone, with differential tissue responses to T4 treatment. PMID: 23940126
- Studies indicate that thyroid hormone receptors alpha and beta (TRTHRA and THRB) genes mutations has been identified in thyroid tumours. PMID: 23271024
- Data from 2 patients (daughter; father) from Greece with frameshift mutation in exon 9 of TRalpha1 (F397fs406X) resulting in new type of thyroid hormone resistance suggest that some symptoms are improved with levothyroxine treatment, others are not. PMID: 23633213
- thyroid hormone receptor action varies by subtype and could could influence physiologic and pharmacologic responses to THs and selective TR modulators (STRMs) PMID: 23300972
- IGFBP-3 interacts with TRalpha1 and inhibits triiodothyronine responsive gene transcription. PMID: 21529443
- conjugation of SUMO to TR has a TR-isoform preference and is important for T3-dependent gene induction and repression. PMID: 22930759
- Thyroid hormone receptor-alpha/NR1D1 polymorphisms were not associated with baseline characteristics, including serum TSH and free thyroxine. None of the polymorphisms were associated with bone mineral density or osteoporotic fractures. PMID: 22224817
- Our data indicates that the IGFBP-6 can interact with thyroid hormone receptor alpha 1 and interfere with heterodimer formation with retinoid x receptor PMID: 21997736
- our study showed associations between the THRA rs939348 polymorphism and systolic blood pressure and the risk of hypertension but not with coronary heart disease. PMID: 21654857
- TR mutations from renal clear cell carcinoma and hepatocellular carcinoma may play tissue-specific roles in carcinogenesis. PMID: 21622534
- Differential interaction of NCoR1 with TR isoforms accounted for the TR isoform-dependent regulation of adipogenesis and that aberrant interaction of NCoR1 with TR could underlie the pathogenesis of lipid disorders in hypothyroidism. PMID: 21389087
- investigation of association/dissociation kinetics for recombinant TRalpha and ligand (125I-T3) PMID: 21508093
- The relationship between the genetic variability of the THRA gene and Alzheimer disease risk remains uncertain but cannot be entirely excluded. PMID: 19427062
- Results highlight v-ErbA's complex mode of action: the oncoprotein is highly mobile and trafficks between the nucleus, cytoplasm, and aggresome, carrying out distinct activities within each compartment. PMID: 21075170
- We found TSHR, TRalpha1, TRalpha2 and TRbeta1 mRNA and proteins expressed in human endometrium PMID: 20691434
- Patients with non-septic shock non-thyroidal illness syndrome show decreased expression of thyroid hormone receptors THRalpha1 and THRbeta in skeletal muscle. PMID: 20736347
- The natural TH 3,5,3'-triodothyroacetic acid (Triac) exhibits a previously unrecognized mechanism of TRbeta selectivity. PMID: 19926848
- The presence of TRs in the penis provides the biological basis for the direct action of thyroid hormones on this organ. PMID: 20141582
- Data suggest that CDK8 plays an important coactivator role in thyroid hormone receptor (TR)-dependent transcription by promoting Pol II recruitment and activation at TR target gene promoters. PMID: 20231357
- A bioassay to evaluate the thyroid disrupting potential of industrial chemical using human TRalpha or TRbeta in S. cerevisiae is described. PMID: 19853653
- Genes for TR-alpha were differentially expressed in subcutaneous vs. omental adipose tissue. Findings suggest that TR alpha1 could contribute to SC adipose tissue expandability in obese subjects. PMID: 19360007
- A conserved lysine in the thyroid hormone receptor-alpha1 DNA-binding domain, mutated in hepatocellular carcinoma, is an allosteric sensor for transcription and contribute to neoplastic disease. PMID: 20053725
- analysis of isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1 PMID: 19628582
- TR expression in human haematopoietic cells depends on thyroid function status, both hypo- and hyperthyroidism significantly influence clonogenicity and induce apoptosis in CD34(+)-enriched stem cells PMID: 19903799
- neurodevelopmental functions of thyroid hormone signaling. PMID: 11861164
- affected receptor amino acid sequences. lost their trans-activation function and exhibited dominant negative activity. PMID: 11889175
- Our results reveal specific alterations in the expression of TRbeta and TRalpha genes in a subset of breast cancer patients, suggesting that deregulation of thyroid hormone target genes may be involved in the generation of this neoplasia. PMID: 12082618
- Less aggressive thyroid cancer was found to be linked to increased thyroid hormone receptor-alpha1 expression and an expanded THRA1 microsatellite. PMID: 12231529
- allosteric changes resulting from binding of T3Ralpha to different response elements, i.e. pHREs versus nHREs, dictate whether a cofactor will function as a coactivator or a corepressor PMID: 12388540
- the nTRE (negative thyroid hormone response element) is responsible for binding of thyroid hormone receptor alpha to the promoter in HeLa cells PMID: 12878587
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相關(guān)疾?。?/div>Hypothyroidism, congenital, non-goitrous, 6 (CHNG6)亞細胞定位:Nucleus.; [Isoform Alpha-2]: Cytoplasm. Nucleus.蛋白家族:Nuclear hormone receptor family, NR1 subfamily
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