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  4. Recombinant Human Ubiquitin-associated protein 2-like (UBAP2L), partial

Recombinant Human Ubiquitin-associated protein 2-like (UBAP2L), partial

  • 中文名稱：
    人UBAP2L重組蛋白
  • 貨號：
    CSB-YP622754HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人UBAP2L重組蛋白
  • 貨號：
    CSB-EP622754HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人UBAP2L重組蛋白
  • 貨號：
    CSB-EP622754HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人UBAP2L重組蛋白
  • 貨號：
    CSB-BP622754HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人UBAP2L重組蛋白
  • 貨號：
    CSB-MP622754HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    FLJ42300; KIAA0144; NICE 4; NICE4; Protein NICE-4; Protein NICE4; Ubap2l; Ubiquitin associated protein 2 like; Ubiquitin-associated protein 2-like; UBP2L_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs). Required for efficient formation of stress granules.
  • 基因功能參考文獻：
    1. UBAP2L plays an oncogenic role in HCC, and knockdown of its expression significantly inhibits HCC growth and metastasis, which may be related to the regulation of PI3K/AKT and P53 signaling pathways by UBAP2L. PMID: 30291221
    2. High UBAP2L expression is associated with breast cancer. PMID: 29196913
    3. UBAP2L was overexpressed in HCC, and patients with high UBAP2L expression had unfavorable prognosis. PMID: 28981479
    4. UBAP2L is amplified in 15% of human primary lung adenocarcinoma specimens. Such patients express higher levels of UBAP2L and show a reduction in survival when compared with those who do not have this gene amplification. PMID: 28754713
    5. UBAP2L plays a critical role in maintenance of the metastatic ability of Hepatocellular Carcinoma Cells cells via SNAIL1 Regulation and is predictive of a poor clinical outcome. PMID: 28334716
    6. These results suggest that UBAP2L has a key role in glioma cell growth, and may act as an oncogene to promote malignant glioma development. PMID: 26310274
    7. arginine residues in the RGG/RG motif of UBAP2L were directly methylated by PRMT1. RGG/RG motif of UBAP2L is essential for the proper alignment of chromosomes. PMID: 26381755
    8. Knockdown of UBAP2L in prostate carcinoma inhibited cell proliferation, migration, and colony formation ability, and blocked cell cycle progression. PMID: 25069639
    9. Two different BMI1-containing PcG complexes regulate hematopoietic stem cell activity, which are distinguishable by the presence of UBAP2L. PMID: 25185265

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  • 亞細胞定位：
    Cytoplasm, Stress granule.
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 29877

    OMIM: 616472

    KEGG: hsa:9898

    STRING: 9606.ENSP00000355343

    UniGene: Hs.490551