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  4. Recombinant Human Ubiquitin carboxyl-terminal hydrolase 19 (USP19), partial

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 19 (USP19), partial

  • 中文名稱：
    人USP19重組蛋白
  • 貨號(hào)：
    CSB-YP025709HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人USP19重組蛋白
  • 貨號(hào)：
    CSB-EP025709HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人USP19重組蛋白
  • 貨號(hào)：
    CSB-EP025709HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人USP19重組蛋白
  • 貨號(hào)：
    CSB-BP025709HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人USP19重組蛋白
  • 貨號(hào)：
    CSB-MP025709HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    USP19
  • Uniprot No.：
  • 別名：
    8430421I07Rik; AI047774; Deubiquitinating enzyme 19; Ubiquitin carboxyl terminal hydrolase 19; Ubiquitin carboxyl-terminal hydrolase 19; Ubiquitin specific peptidase 19; Ubiquitin specific processing protease 19; Ubiquitin specific protease 19; Ubiquitin thioesterase 19; Ubiquitin thiolesterase 19; Ubiquitin-specific-processing protease 19; UBP19_HUMAN; Usp19; Zinc finger MYND domain containing protein 9; Zinc finger MYND domain-containing protein 9; ZMYND9
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked ubiquitin chains.
  • 基因功能參考文獻(xiàn)：
    1. USP19 is a key factor in modulating DNA damage repair by targeting HDAC1/2 K63-linked ubiquitination, cells with deletion or decreased expression of USP19 might cause genome instability and even contribute to tumorigenesis. PMID: 27517492
    2. findings establish USP19 is a negative regulator of the cellular type I IFN antiviral response to enterovirus 71 (EV71) infection; through the decrease of K63-linked polyubiquitination of TRAF3, USP19 suppresses cellular type I IFN signaling, supporting EV71 propagation in host cells PMID: 28391724
    3. The regulation of CORO2A through the deubiquitinating activity of USP19 affected the transcriptional repression activity of the retinoic acid receptor (RAR), suggesting that USP19 may be involved in the regulation of RAR-mediated adipogenesis. PMID: 27129179
    4. HRD1 is a novel substrate for USP19. USP19 negatively regulates the ubiquitination of HRD1 and prevents it from undergoing proteasomal degradation. PMID: 27827840
    5. USP19 positively regulates autophagy and antiviral immune responses by deubiquitinating Beclin-1. PMID: 26988033
    6. In conjunction with HSP90, the cytoplasmic USP19 may play a key role in triage decision for the disease-related polyQ-expanded substrates, suggesting a function of USP19 in quality control of misfolded proteins by regulating their protein levels PMID: 26808260
    7. Expression of USP19 correlates with that of MuRF1 and MAFbx/atrogin-1 in skeletal muscles PMID: 26048142
    8. These results clarify the role of USP19 in ERAD and suggest a novel DUB regulation that involves chaperone association and membrane integration PMID: 24356957
    9. USP19 interacts with the ubiquitin ligases SIAH1 and SIAH2, which promote USP19 ubiquitylation and degradation by the proteasome. PMID: 23500468
    10. experimentally verified the targets heterogeneous nuclear ribonucleoprotein U, phosphatidylinositol-3-OH kinase, the WNK (with-no-lysine) kinase family and USP19 (ubiquitin-specific peptidase 19) as vulnerable nodes in the host cellular defence system against viruses PMID: 22810585
    11. ubiquitin-specific protease-19 (USP19) interacts with components of the hypoxia pathway including HIF-1alpha and rescues it from degradation independent of its catalytic activity PMID: 22128162
    12. The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2. PMID: 21849505
    13. ability of USP19 to regulate cell proliferation and p27(Kip1) levels; complete loss of USP19 function on cell growth may arise as a result of oncogenic transformation of cells. PMID: 21264218
    14. USP19 is the first example of a membrane-anchored deubiquitinating enzymes involved in the turnover of endoplasmic-reticulum-associated degradation substrates. PMID: 19465887

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    Peptidase C19 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12617

    OMIM: 614471

    KEGG: hsa:10869

    STRING: 9606.ENSP00000401197

    UniGene: Hs.255596