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  4. Recombinant Human Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H), partial

Recombinant Human Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H), partial

  • 中文名稱：
    Recombinant Human Voltage-dependent T-type calcium channel subunit alpha-1H(CACNA1H) ,partial,Yeast
  • 貨號：
    CSB-YP004404HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Voltage-dependent T-type calcium channel subunit alpha-1H(CACNA1H) ,partial,Yeast
  • 貨號：
    CSB-EP004404HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Voltage-dependent T-type calcium channel subunit alpha-1H(CACNA1H) ,partial,Yeast
  • 貨號：
    CSB-EP004404HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Voltage-dependent T-type calcium channel subunit alpha-1H(CACNA1H) ,partial,Yeast
  • 貨號：
    CSB-BP004404HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Voltage-dependent T-type calcium channel subunit alpha-1H(CACNA1H) ,partial,Yeast
  • 貨號：
    CSB-MP004404HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Alpha1 3.2; Alpha13.2; CAC1H_HUMAN; CACNA 1H; CACNA1 H; CACNA1 HB; Cacna1h; CACNA1HB; Calcium channel alpha13.2 subunit; Calcium channel voltage dependent T type alpha 1H subunit; Calcium channel; voltage-dependent; T type; alpha 1Hb subunit; Cav 3.2; Cav T.2; Cav3.2; CavT.2; EIG 6; EIG6; Low voltage activated calcium channel alpha 13.2 subunit; Low voltage activated calcium channel alpha1 3.2 subunit; Low-voltage-activated calcium channel alpha1 3.2 subunit; MNCb 1209; T type Cav3.2; Voltage dependent t type calcium channel alpha 1H subunit; Voltage gated calcium channel alpha subunit Cav 3.2; Voltage gated calcium channel alpha subunit Cav T.2; Voltage gated calcium channel alpha subunit Cav3.2; Voltage gated calcium channel alpha subunit CavT.2; Voltage-dependent T-type calcium channel subunit alpha-1H; Voltage-gated calcium channel subunit alpha Cav3.2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia.
  • 基因功能參考文獻：
    1. These findings reveal spectrin (alpha/beta) / ankyrin B cytoskeletal and signaling proteins as key regulators of T-type calcium channels expressed in the nervous system. PMID: 29720258
    2. In colonic biopsies, the Cav3.2 mRNA level was significantly higher in the irritable bowel syndrome group compared to controls. PMID: 27196538
    3. Here we show that T-type channels Cav3.1 and Cav3.2 are present in the lung and PASMCs from iPAH patients and control subjects. The blockade of T-type channels by the specific blocker, TTA-A2, prevents cell cycle progression and PASMCs growth PMID: 28655554
    4. Our data establish Stac1 as an important modulator of T-type channel expression and provide new insights into the molecular mechanisms underlying the trafficking of T-type channels to the plasma membrane. PMID: 27149520
    5. CACNA1H variant is associated with differential antiepileptic drug response in childhood absence epilepsy. PMID: 28165634
    6. There is a direct link between CACNA1H(M1549V) mutation and an increased aldosterone production. This suggests that calcium channel blockers may be beneficial in the treatment of a subset of patients with primary aldosteronism. PMID: 27258646
    7. CACNA1H might be a susceptibility gene predisposing to PA with different phenotypic presentations, opening new perspectives for genetic diagnosis and management of patients with PA. PMID: 27729216
    8. modulation of N-linked glycosylation of hCav3.2 channels may play an important physiological role PMID: 26745591
    9. heterozygous mutations identified in a pediatric patient with chronic pain and absence seizures result in loss of channel function, with significantly smaller current densities across a wide range of voltages when co-expressed in tsA-201 cells. PMID: 26706850
    10. Study revealed no association between the 15 tagSNPs of CACNA1A, 1C, and 1H and antiepileptic drug efficacy in the Chinese Han epileptic population; the TAGAA haplotype of CACNA1A may be a risk factor for drug resistance PMID: 26216687
    11. Cav3.2 channels are highly phosphorylated in the mammalian brain and establish phosphorylation as an important mechanism involved in the dynamic regulation of Cav3.2 channel gating properties PMID: 26483470
    12. Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism. PMID: 25907736
    13. reveal an unexpected role of CaV3.2 channels in regulating NMDA-R-mediated transmission and a novel epileptogenic mechanism for human childhood absence epilepsy PMID: 26220996
    14. The I-II loop of the Cav3.2 protein inhibits neuronal Cav3.1 and Cav3.2 channels. PMID: 25931121
    15. C456S mutation leads to substantially increased excitability of cultured neurons due to increased spontaneous firing rate. PMID: 24277868
    16. N-linked glycosylation of Cav3.2 not only controls surface expression. PMID: 23503728
    17. Data indicate that endogenous/exogenous hydrogen sulfide regulates function of T-type Ca(2+) channel Cav3.2 expressed in HEK293 cells PMID: 24508802
    18. It plays pivotal roles in processing of pain signals.(review) PMID: 23903007
    19. Both Asp residues critically control the biophysical properties of Ca(v)3.2, including relative permeability between Ba2+ and Ca2+, voltage dependency of channel activation, Cd2+ blocking sensitivity, and pH effects, in distinctive ways. PMID: 23849427
    20. Cav3.2 is differently expressed in normal pleura and malignant pleural mesothelioma PMID: 22564432
    21. Data suggest a pathway in which thioredoxin (Trx) acts as a tonic, endogenous regulator of Cav3.2 channels, while heme oxygenase-1 (HO-1)-derived carbon dioxide (CO) disrupts this regulation, causing channel inhibition. PMID: 23671274
    22. Results indicate that the S4-S5 and S6 helices from adjacent domains are energetically coupled during the activation of a low voltage-gated T-type CaV3.2 channel. PMID: 23970551
    23. A novel Cav3-KCa1.1 signaling complex has been identified where Cav3-mediated calcium entry enables KCa1.1 activation over a wide range of membrane potentials. PMID: 23626738
    24. Cav3.2 regulates calcineurin/NFAT pathway through both the Ca(2+) influx and calcineurin binding PMID: 23669360
    25. Our results support the notion that ion channel autoimmunity might at least partially contribute to HaNDL pathogenesis and occurrence of neurological symptoms. PMID: 23111027
    26. The abnormal mRNA expressions of T-type channel alpha1H and alpha1G may be one of the causes of declined semen quality and infertility in varicocele patients. PMID: 22574369
    27. ZnT-1 enhances the activity of CaV3.1 and CaV3.2 via activation of Ras-ERK signaling pathways in the plasma membrane. PMID: 22572848
    28. Cav3.2 channels were expressed at the membrane of large portions of cells, with no likely relation to Cav3.1 expression or apoptosis. PMID: 22469755
    29. A Ca(v)3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis. PMID: 22130660
    30. Data showed expression of L-type (Ca(v) 1.2), P/Q-type (Ca(v) 2.1), and T-type subtype (Ca(v) 3.1 and Ca(v) 3.2) voltage-gated calcium channels (Ca(v)s) in renal artery and dissected intrarenal blood vessels from nephrectomies. PMID: 21788606
    31. The function of T-type Ca(2+) channels is important for the proliferation of human ovarian cancer cells. PMID: 21438841
    32. Review: I-II loops of T-channels play critical roles in the trafficking and gating of these channels. This loop contains an intracellular gating brake that is essential to their ability open after small depolarizations of the membrane. PMID: 21099341
    33. Ca(V)3.2 alternative splicing generates significant T-type Ca channel structural and functional diversity with potential implications relevant to cardiac developmental and pathophysiological states PMID: 20699644
    34. Present evidence that N2O-based inhibition of Cav3.2 channels is mediated by free radical signalling and results in analgesia. PMID: 21059758
    35. functional modulation of the Ca(v)3.2 channels by Cav-3 is important for understanding the compartmentalized regulation of Ca(2+) signaling during normal and pathological processes. PMID: 21084288
    36. T-type calcium channel gene-CACNA1H might be a susceptibility gene to childhood absence epilepsy. PMID: 15833171
    37. Review discusses mutations of the Cav3.2 isoform (CACNA1H gene) that enhance channel activity and their association with idiopathic generalized epilepsies, whereas mutations that disrupt its activity are associated with autism spectrum disorders. PMID: 19903827
    38. We conclude that low voltage activated voltage-operated Ca(2+) channels are expressed in cells of the human male germ line. PMID: 11751928
    39. characterization in terms of activation and inactivation properties as well as cation permeability PMID: 14529577
    40. Ca(v)3.2 has a role in calcium influx during physiological activation and mutations may be causative in the propensity for seizures in patients with childhood absence epilepsy PMID: 14729682
    41. recombinant low voltage-activated T-type Ca channels exhibit a small, though clearly evident, window T-type Ca(2)(+) current which is also present in native channels from different neuronal types--REVIEW PMID: 15498803
    42. CACNA1H is a susceptibility gene in complex idiopathic generalized epilepsy PMID: 15852375
    43. Data indicate that Domain IV/S4 of Ca(v)3.2 is an activation domain and is not involved in inactivation from the open state. PMID: 16133267
    44. Cloning and calcium channel characteristics of Cav3.2 isoforms. PMID: 16301824
    45. His-191 in the S3-S4 loop is a critical residue conferring nickel block to Ca(v)3.2 PMID: 16377633
    46. inhibitory effects of amiodarone on the modified T-type Cav3.2 Ca2+ channel created by long-term amiodarone treatment PMID: 16443692
    47. The expression of CACNA1H in breast cancer has been confirmed by RT-PCR. PMID: 16475676
    48. Linkage analysis of 44 pedigrees provided no evidence for a locus in the CACNA1H region; no Chinese variants were found in 220 unrelated patients. PMID: 16504478
    49. CACNA1H RNA is alternatively spliced at 12-14 sites where it can destroy, create or change the regulatory specificity of predicted exonic splicing enhancer sequences that may control splicing regulation. PMID: 16565161
    50. functional analysis shows that missense mutations significantly reduce Ca(V)3.2 channel activity and thus could affect neuronal function and potentially brain development and could contribute to the development of the ASD phenotype PMID: 16754686

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  • 相關(guān)疾?。?/div>
    Epilepsy, idiopathic generalized 6 (EIG6); Epilepsy, childhood absence 6 (ECA6); Hyperaldosteronism, familial, 4 (HALD4)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1H subfamily
  • 組織特異性：
    Expressed in the adrenal glomerulosa (at protein level). In nonneuronal tissues, the highest expression levels are found in the kidney, liver, and heart. In the brain, most abundant in the amygdala, caudate nucleus, and putamen. In the heart, expressed in
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1395

    OMIM: 607904

    KEGG: hsa:8912

    STRING: 9606.ENSP00000334198

    UniGene: Hs.459642