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  4. Recombinant Human WD repeat and HMG-box DNA-binding protein 1 (WDHD1), partial

Recombinant Human WD repeat and HMG-box DNA-binding protein 1 (WDHD1), partial

  • 中文名稱：
    人WDHD1重組蛋白
  • 貨號：
    CSB-YP025994HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人WDHD1重組蛋白
  • 貨號：
    CSB-EP025994HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人WDHD1重組蛋白
  • 貨號：
    CSB-EP025994HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人WDHD1重組蛋白
  • 貨號：
    CSB-BP025994HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人WDHD1重組蛋白
  • 貨號：
    CSB-MP025994HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    WDHD1
  • Uniprot No.：
  • 別名：
    WDHD1; AND1; WD repeat and HMG-box DNA-binding protein 1; Acidic nucleoplasmic DNA-binding protein 1; And-1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

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靶點詳情

  • 功能：
    Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication.
  • 基因功能參考文獻：
    1. And-1 interacts with CtIP and that these interactions are required for DNA damage checkpoint maintenance, thereby linking DNA processing with prolonged cell cycle arrest to allow sufficient time for DNA repair. PMID: 27940552
    2. important role of And-1 in homologous recombination repair by regulating CtIP-mediated DNA double-strand break end resection PMID: 27940557
    3. findings provide important insights into the mechanistic details of human AND-1 function, advancing our understanding of replisome formation during eukaryotic replication. PMID: 28381552
    4. The WDHD1 gene, one of the genes that is upregulated in human papillomavirus E7-expressing cells, was found to play an important role in E7-induced G1 checkpoint abrogation and rereplication PMID: 27099318
    5. Results provide additional evidence suggesting that WDHD1 is involved in the mismatch repair pathway. PMID: 27037360
    6. RecQL4-dependent association of Mcm10 and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells. PMID: 25602958
    7. And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress. PMID: 26082189
    8. The Ctf4-CMG complex contains a homodimeric Ctf4 that acts as a platform linking polymerase alpha to the monomeric hCMG complex. PMID: 24255107
    9. And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres. PMID: 23184928
    10. Human And-1 facilitates loading of the MCM2-7 helicase onto chromatin during the assembly of prereplicative complex. PMID: 23093411
    11. Data show that And-1 forms a complex with both histone H3 and Gcn5. PMID: 21725360
    12. in human cells, hCtf4 plays an essential role in DNA replication and its ability to stimulate the replicative DNA polymerases may contribute to this effect PMID: 20089864
    13. Mcm10 is required for chromatin loading of And-1. PMID: 17761813
    14. AND-1 coordinates multiple cellular events in S phase and G2 phase. PMID: 19439411
    15. Assembly of the Cdc45-Mcm2-7-GINS complex requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. PMID: 19805216

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  • 亞細胞定位：
    Nucleus, nucleoplasm.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23170

    OMIM: 608126

    KEGG: hsa:11169

    STRING: 9606.ENSP00000353793

    UniGene: Hs.385998