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  4. Recombinant Human Zinc finger protein 268 (ZNF268), partial

Recombinant Human Zinc finger protein 268 (ZNF268), partial

  • 中文名稱：
    人ZNF268重組蛋白
  • 貨號(hào)：
    CSB-YP026625HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人ZNF268重組蛋白
  • 貨號(hào)：
    CSB-EP026625HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人ZNF268重組蛋白
  • 貨號(hào)：
    CSB-EP026625HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ZNF268重組蛋白
  • 貨號(hào)：
    CSB-BP026625HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ZNF268重組蛋白
  • 貨號(hào)：
    CSB-MP026625HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ZNF268
  • Uniprot No.：
  • 別名：
    ZNF268Zinc finger protein 268; Zinc finger protein HZF3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.; Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.
  • 基因功能參考文獻(xiàn)：
    1. The nuclear localization activity of KRAB domain is a conserved feature of ZNF268. PMID: 23665872
    2. These results reveal a novel role of ZNF268b2 that contributes to cervical carcinogenesis in part through enhancing NF-kappaB signaling. PMID: 23091055
    3. ZNF268 is a crucial downstream target and effector of GATA-1 PMID: 22235304
    4. This protein has a conserved KRAB domain which localizes to the nucleus and has transcriptional repressor activity. PMID: 12822888
    5. ZNF268 plays a role in early human liver development most likely by functioning through a cytoplasmic mechanism PMID: 15547661
    6. 4 alternative transcripts of ZNF268 were detected in the human blood cells. PMID: 16735226
    7. ZNF268 gene promoter is atypical and requires an intragenic element located within the first exon that mediates the effect of CREB for its activity PMID: 16787922
    8. ZNF268 gene may function as a transcriptional activator in the growth and differentiation of cells in development and/or pathogenesis. PMID: 16865230
    9. HTLV-1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding PMID: 18375384
    10. results indicate that a spliced form of ZNF268 lacking the KRAB domain is located in the cytosol, where it seems to play a role in TNF-alpha-induced NF-kappaB activation by interacting with the IKK complex. PMID: 18677094
    11. Results demonstrate that the mammalian gene ZNF268 is regulated by hUpf1 via its promoter. PMID: 18774934
    12. aberrant alternative splicing of ZNF268 is a potential prognostic factor of and may contribute to human hematological malignancies. PMID: 18949428

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  • 亞細(xì)胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Nucleus. Cytoplasm.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性：
    Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13061

    OMIM: 604753

    KEGG: hsa:10795

    STRING: 9606.ENSP00000228289

    UniGene: Hs.124047