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  4. Recombinant Human Zinc finger transcription factor Trps1 (TRPS1), partial

Recombinant Human Zinc finger transcription factor Trps1 (TRPS1), partial

  • 中文名稱：
    人TRPS1重組蛋白
  • 貨號：
    CSB-YP883395HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TRPS1重組蛋白
  • 貨號：
    CSB-EP883395HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TRPS1重組蛋白
  • 貨號：
    CSB-EP883395HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TRPS1重組蛋白
  • 貨號：
    CSB-BP883395HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TRPS1重組蛋白
  • 貨號：
    CSB-MP883395HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TRPS1
  • Uniprot No.：
  • 別名：
    GC79; LGCR; Transcriptional repressor GATA binding 1; Tricho rhino phalangeal syndrome I; Tricho-rhino-phalangeal syndrome type I protein; Trichorhinophalangeal syndrome I; Trichorhinophalangeal syndrome I homolog; TRPS 1; trpS1; TRPS1 gene; TRPS1_HUMAN; Zinc finger protein GC79; Zinc finger transcription factor TRPS 1; Zinc finger transcription factor Trps1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
  • 基因功能參考文獻(xiàn)：
    1. In Pseudohypoparathyroidism, mutations were found in PRKAR1A, PDE4D, TRPS1, and PTHLH. PMID: 29499646
    2. Two Pakistani families with sequence variants in GDF5 and TRPS1 causing brachydactyly type C and tricho-rhino-phalangeal syndrome type III are described. PMID: 29436063
    3. The results of this study indicated a prominent role of TRPS1 in subependymoma development. PMID: 28528424
    4. Results showed that TRPS1 along with GATA3 are distinctively overexpressed in breast cancer (BC) among all GATA family members and predict better survival in patients with BC. TRPS1 is then a distinctive biomarker and essential prognostic factor in BC. PMID: 28423734
    5. Downregulation of the TRPS1 protein, which is a transcriptional target of hsa-miR-26b-5p, was associated with radiation exposure. PMID: 28944451
    6. The first patient has a novel heterozygous two-base-pair deletion of nucleotides at 3198-3199 (c.3198-3199delAT) in the TRPS1 gene causing a translational frameshift and subsequent alternate stop codon. The second patient has a 3.08 million base-pair interstitial deletion at 8q23.3 (113,735,487-116,818,578), which includes the TRPS1 gene and CSMD3 PMID: 28256045
    7. the twins described by Fitzsimmons had heterozygous mutations in the SACS gene, the gene responsible for autosomal recessive spastic ataxia of Charlevoix Saguenay as well as a heterozygous mutation in the TRPS1, the gene responsible in Trichorhinophalangeal syndrome type 1A TBL1XR1 mutation was identified in the patient described in 2009 as contributing to his cognitive impairment and autistic features.. PMID: 27133561
    8. Clinically, three patients had TRPS I, two with multiple supernumerary teeth. The clinical impression was confirmed by a novel TRPS1 mutation. PMID: 27706911
    9. in this kindred support the previous genotype-phenotype results suggesting that patients with more pronounced facial characteristics and more severe shortening of hands and feet are more likely to have mutation in exon 6 of TRPS1 PMID: 28468609
    10. Down-regulation of TRPS1 by miR-373, acting as a transcriptional activator, promotes epithelial-mesenchymal transition (EMT) and metastasis by repressing FOXA1 transcription, expanding upon its previously reported role as a transcription repressor. PMID: 26969828
    11. TRPS1 gene was responsible for most of the TRPS phenotype PMID: 27826100
    12. Data show that co-silencing of tricho-rhino-phalangeal-syndrome (TRPS1) and cathepsin D (Cath-D) in breast cancer cells (BCC) affects the transcription of cell cycle and proliferation. PMID: 26183398
    13. Trps1 plays a crucial role in osteosarcoma angiogenesis, metastasis and clinical surgical stage. PMID: 26377811
    14. Single nucleotide polymorphisms in TRPS1 gene is associated with Coronary Artery Disease. PMID: 25328121
    15. Missense mutations are located exclusively in exon 6 and 7 of TRPS1 in patients with tricho-rhino-phalangeal syndrome. PMID: 25792522
    16. TRPS1 haploinsufficiency results in STAT3 and SOX9 mRNA expression in Trichorhinophalangeal syndrome. PMID: 25136899
    17. Trps1 is involved in non-anastomotic biliary structure pathogenesis following liver transplantation and negatively correlates with biliary epithelial cell epithelial-mesenchymal transition and biliary fibrosis in liver grafts. PMID: 25886207
    18. our study proposes that TRPS1 acts as a central hub in the control of cell cycle and proliferation during cancer development PMID: 25277197
    19. Identification of a novel missense mutation c.2726G>A (p.C909Y) of the TRPS1 gene in a family with trichorhinophalangeal syndrome type I. PMID: 25333908
    20. truncated protein from mutant allele may be stably expressed in patient's hair follicles PMID: 24909213
    21. we identified a mutation in the TRPS1 gene The same mutation was detected as a 10% mosaic mutation by Pyrosequencing in blood-derived DNA from his healthy mother. this is the first time that somatic mosaicism has been identified in TRPSI PMID: 23572024
    22. TRPS1 gene expressionis associated with different epithelial mesenchymal transformation markers in ERalpha-positive and ERalpha-negative breast cancers. PMID: 24934762
    23. Trps1 is required for odontoblast maturation by supporting expression of genes crucial for initiating the mineralization process. PMID: 25128529
    24. association between SNP within TRPS1 and BMD PMID: 24416236
    25. TRPS1 promotes angiogenesis and affects VEGFA expression in breast cancer. PMID: 24595984
    26. TRPS-1 is an independent prognostic marker in early-stage breast cancer and a new epithelial-to-mesenchymal transition marker that can distinguish patients with estrogen receptor-positive breast cancer who will respond longer to adjuvant endocrine therapy PMID: 23729783
    27. A role for Trps1 in the regulation of MDR1 expression in osteosarcoma. PMID: 24491996
    28. Identification of a new mutation in TRPS1 gene leading to tricho-rhino-phalangeal syndrome I in a Chinese patient PMID: 23293878
    29. we report the first familial balanced translocation [t(8;13)(q24.11;q21.31)] leading to trichorhinophalangeal syndrome I with a breakpoint 87 kb from the TRPS1 5' end. PMID: 23835950
    30. The increased expression of TRPS1 may be involved in the pathogenesis and progression of colon cancer. PMID: 23762846
    31. The strong expression of TRPS-1 may serve as a good prognostic marker in breast cancer. PMID: 24074613
    32. Mutations in the amino terminus of this transcription factor result in TRPS I syndrome. PMID: 22481165
    33. Genetic variation in TRPS1 may regulate hip geometry as well as bone mineral density PMID: 22306695
    34. TRPS1 codon 952 constitutes a mutational hot spot in trichorhinophalangeal syndrome type I and could be associated with intellectual disability. PMID: 22127049
    35. miR-221/222 targeting of trichorhinophalangeal 1 (TRPS1) promotes epithelial-to-mesenchymal transition in breast cancer. PMID: 21868360
    36. we found critical differences in TRPS-1 expression in primary breast cancer PMID: 21761348
    37. TRPS-1 was also found to be expressed in a high proportion of ER(-) ductal epithelial breast cancers PMID: 21761336
    38. TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer PMID: 21673316
    39. nonsense mutations result in premature stop codons in exon 4 or exon 5 and frame shifts from the point of deletion or two-to-one substitution also lead to premature stop codons downstream. PMID: 20394624
    40. Mutation in TRPS1 is associated with tricho-rhino-pharangeal syndrome. PMID: 20635356
    41. Trichorhinophalangeal syndrome:report on a family where the father & 3 children have a novel out-of-frame indel, the largest intragenic indel reported to date & comment on intrafamilial consistency of the resulting TRPS type I phenotype PMID: 20177376
    42. Review: Structure and function of GC79/TRPS1, a novel androgen-repressible apoptosis gene PMID: 11773701
    43. novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes PMID: 11950061
    44. homologous domains from the TRPS-1 and Drosophila Hunchback proteins support homodimerization, but not heterodimerization with Ikaros PMID: 12620233
    45. TRPS1 activity is regulated by RNF4 PMID: 12885770
    46. Our results suggest a role of TRPS1 in androgen regulation of prostate-specfici antigen gene expression PMID: 14680804
    47. TRPS-1 protein and gene were expressed in >90% of early- and late-stage breast cancer, including ductal carcinoma in situ and invasive ductal, lobular, and papillary carcinomas PMID: 16043716
    48. We show here that TRPS1 is SUMOylated at multiple sites, both in vivo and in vitro, through interaction with UBC9. Overexpression of wild-type UBC9 enhances TRPS1-mediated transcriptional repression. PMID: 17391059
    49. suggests a possible involvement of TRPS1 in oxidative stress, and possibly in apoptosis in androgen-independent DU145 prostate cancer cells PMID: 17467349
    50. study reports a family affected by a mild form of trichorhinophalangeal syndrome type I; mutation analysis showed a missense mutation (R952C) in exon 7 of the TRPS1 gene PMID: 17854380

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  • 相關(guān)疾?。?/div>
    Tricho-rhino-phalangeal syndrome 1 (TRPS1); Tricho-rhino-phalangeal syndrome 2 (TRPS2); Tricho-rhino-phalangeal syndrome 3 (TRPS3)
  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12340

    OMIM: 150230

    KEGG: hsa:7227

    STRING: 9606.ENSP00000379065

    UniGene: Hs.657018