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  4. Recombinant Human herpesvirus 1 Capsid vertex component 2 (CVC2), partial

Recombinant Human herpesvirus 1 Capsid vertex component 2 (CVC2), partial

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  • 中文名稱：
    Recombinant Human herpesvirus 1 Capsid vertex component 2 (CVC2), partial
  • 貨號(hào)：
    CSB-EP320727HWY
  • 規(guī)格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    CVC2
  • Uniprot No.：
  • 種屬：
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    43.8 kDa
  • 表達(dá)區(qū)域：
    1-356aa
  • 氨基酸序列
    MDPYCPFDALDVWEHRRFIVADSRNFITPEFPRDFWMSPVFNLPRETAAEQVVVLQAQRTAAAAALENAAMQAAELPVDIERRLRPIERNVHEIAGALEALETAAAAAEEADAARGDEPAGGGDGGAPPGLAVAEMEVQIVRNDPPLRYDTNLPVDLLHMVYAGRGATGSSGVVFGTWYRTIQDRTITDFPLTTRSADFRDGRMSKTFMTALVLSLQACGRLYVGQRHYSAFECAVLCLYLLYRNTHGAADDSDRAPVTFGDLLGRLPRYLACLAAVIGTEGGRPQYRYRDDKLPKTQFAAGGGRYEHGALASHIVIATLMHHGVLPAAPGDVPRDASTHVNPDGVAHHDDINRAA
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP. May mediate the capsid docking to the nuclear pore allowing entry of the viral genome into the host nucleus through binding to host nucleoporins NUP214.
  • 基因功能參考文獻(xiàn)：
    1. These results demonstrate that the pUL25 capsid protein has a critical role in releasing viral DNA from nuclear pore complex-bound capsids. PMID: 28490590
    2. detailed analyses, including quantitative mass spectrometry of the protein composition of the capsids, revealed that both pUL17 and pUL25 are required to stabilize the capsid shells at the vertices. PMID: 28381566
    3. The data reveals that the loosely formed capsid structure is reinforced post-assembly by the minor capsid protein UL25 in HSV-1. PMID: 25053840
    4. Host C9orf9 promotes viral proliferation via interaction with HSV-1 UL25 protein. PMID: 21667337
    5. Residues 1 to 27 of UL25 contact the hexon adjacent to the penton. A second region, most likely centered on amino acids 26 to 39, contacts the triplex that is one removed from the penton. PMID: 21411517
    6. These findings reveal a new role for pUL25 in virion assembly, consistent with its flexible structure and location on the capsid. PMID: 20181717
    7. These results support the view that UL25 is present on incoming capsids with the capsid-binding domain of UL25 located on the surface of the mature DNA-containing capsid. PMID: 20109467
    8. These results suggest that UL17 is required for efficient incorporation of UL25 into B capsids. PMID: 16474120
    9. crystallographic structure of the region corresponding to amino acids 134 to 580 at 2.1-Angstroms resolution; structure reveals a novel fold, distinctive electrostatic distribution & a unique architecture in which flexible loops emanate from a stable core PMID: 16474137
    10. UL25 and UL17 are two essential minor capsid proteins of HSV-1, implicated in DNA packaging and capsid maturation PMID: 17531807
    11. The UL25 gene product of herpes simplex virus type 1 is involved in uncoating of the viral genome. PMID: 18448531
    12. amino acids 1 to 50 of UL25 are essential for its stable interaction with capsids and that the C terminus is essential for DNA packaging and the production of infectious virus through its interactions with other viral packaging or tegument proteins. PMID: 18945788
    13. pUL25 acts as an interface between the incoming capsid and the nuclear pore complex. PMID: 19386703
    14. the pU(L)17/pU(L)25 complex requires multiple viral proteins and functions for proper localization and biochemical behavior in the infected cell. PMID: 19812148

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  • 亞細(xì)胞定位：
    Virion. Host nucleus.
  • 蛋白家族：
    Herpesviridae CVC2 protein family
  • 數(shù)據(jù)庫鏈接：

    KEGG: vg:2703377