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Recombinant Influenza A virus Protein PB1-F2 (PB1)

  • 中文名稱：
    Recombinant Influenza A virus Protein PB1-F2(PB1),Yeast
  • 貨號：
    CSB-YP315190IEF
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Influenza A virus Protein PB1-F2(PB1),Yeast
  • 貨號：
    CSB-EP315190IEF
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Influenza A virus Protein PB1-F2(PB1),Yeast
  • 貨號：
    CSB-EP315190IEF-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Influenza A virus Protein PB1-F2(PB1),Yeast
  • 貨號：
    CSB-BP315190IEF
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Influenza A virus Protein PB1-F2(PB1),Yeast
  • 貨號：
    CSB-MP315190IEF
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PB1
  • Uniprot No.：
  • 別名：
    PB1; Protein PB1-F2
  • 種屬：
    Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-90
  • 氨基酸序列
    MEQEQDTPWT QSTEHINIQK RGNGQRTQRL EHPNSIRLMD HYLRIMSRVG MHKQIVYWKQ WLSLKNPTQG SLKTRVLKRW KLFSKQEWIS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays an important role in promoting lung pathology in both primary viral infection and secondary bacterial infection. Promotes alteration of mitochondrial morphology, dissipation of mitochondrial membrane potential, and cell death. Alternatively, inhibits the production of interferon in the infected cell at the level of host mitochondrial antiviral signaling MAVS. Its level of expression differs greatly depending on which cell type is infected, in a manner that is independent of the levels of expression of other viral proteins. Monocytic cells are more affected than epithelial cells. Seems to disable virus-infected monocytes or other host innate immune cells. During early stage of infection, predisposes the mitochondria to permeability transition through interaction with host SLC25A6/ANT3 and VDAC1. These proteins participate in the formation of the permeability transition pore complex (PTPC) responsible of the release of mitochondrial products that triggers apoptosis.
  • 基因功能參考文獻：
    1. This study provides evidence that the accessory protein PB1-F2 is required in zoonotic avian viruses, such as highly pathogenic H5N1 isolates, to overcome the restriction of the viral polymerase subunit PA by human HAX-1. PMID: 29563290
    2. The 66S polymorphism of PB1-F2 modulates interferon activity, and four C-terminal amino acids, 62L, 75R, 79R, and 82L, contribute to cytokine release and inflammatory responses. PMID: 23499672
    3. PB1-F2 of H5N1 markedly influences the expression of the host transcriptome: first delays the initial immune response but increases the pulmonary inflammatory response during the late stages of infection. PMID: 23469251
    4. PB1-F2 is a pathogenicity determinant for HPAIV (A/Viet Nam/1203/2004, VN1203 (H5N1)) in both mammals and birds PMID: 21852950
    5. PB1-F2 exacerbates innate immune response PMID: 20844191

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  • 亞細胞定位：
    Host mitochondrion inner membrane. Host nucleus. Host cytoplasm, host cytosol.
  • 蛋白家族：
    Influenza viruses PB1-F2 family
  • 數(shù)據(jù)庫鏈接：

    KEGG: vg:3896424