Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Influenza B virus Hemagglutinin (HA), partial

Recombinant Influenza B virus Hemagglutinin (HA), partial

  • 中文名稱：
    Recombinant Influenza B virus Hemagglutinin(HA) ,partial,Yeast
  • 貨號：
    CSB-YP361061IJK
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Influenza B virus Hemagglutinin(HA) ,partial,Yeast
  • 貨號：
    CSB-EP361061IJK
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Influenza B virus Hemagglutinin(HA) ,partial,Yeast
  • 貨號：
    CSB-EP361061IJK-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Influenza B virus Hemagglutinin(HA) ,partial,Yeast
  • 貨號：
    CSB-BP361061IJK
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Influenza B virus Hemagglutinin(HA) ,partial,Yeast
  • 貨號：
    CSB-MP361061IJK
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HA
  • Uniprot No.：
  • 別名：
    HA; Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]
  • 種屬：
    Influenza B virus (strain B/Lee/1940)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
  • 基因功能參考文獻：
    1. Although random reassortment event may generate unique reassortants, detailed phylogenetic classification of gene segments showed possible genetic linkage between PA and NA genes in B/Phuket/3073/2013-like viruses, which requires further investigation. Understanding on reassortment patterns in influenza B evolution may contribute to future vaccine design. PMID: 28129386
    2. Results show that in influenza B viruses genomic segments coding for PB1 and PB2 and hemagglutinin proteins have been maintained in only Victoria and Yamagata lineages. PMID: 25323575
    3. Mutation Phe95-->Tyr in influenza B virus HA enhance receptor binding. PMID: 24503069
    4. HAs of diverged influenza B virus strains display much stronger molecular interactions with terminal sialic acid of bound receptors. PMID: 24074573
    5. These findings indicate that the cytoplasmic tail domain of influenza B virus hemagglutinin is important for efficient incorporation of hemagglutinin into virions and tight lipid raft association. PMID: 22896616
    6. Non-synonymous mutations resulting in the loss of the N-glycosylation site at positions 197-199 of hemagglutinin have been positively selected to a far greater degree in egg-cultured strains than in other strains PMID: 19950248
    7. results demonstrate that Leu at the end portion of the C terminus of the HA-CT (cytoplasmic tail) is not essential for membrane fusion, but that the hydrophobicity of the single amino acid at this position plays an important role in syncytium formation PMID: 16690932

    顯示更多

    收起更多

  • 亞細胞定位：
    Virion membrane; Single-pass type I membrane protein. Host apical cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Influenza viruses hemagglutinin family
  • 數(shù)據(jù)庫鏈接：

    KEGG: vg:956538