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  4. Recombinant Mouse Aspartyl/asparaginyl beta-hydroxylase (Asph), partial

Recombinant Mouse Aspartyl/asparaginyl beta-hydroxylase (Asph), partial

  • 中文名稱：
    Recombinant Mouse Aspartyl/asparaginyl beta-hydroxylase(Asph),partial,Yeast
  • 貨號：
    CSB-YP803930MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Aspartyl/asparaginyl beta-hydroxylase(Asph),partial,Yeast
  • 貨號：
    CSB-EP803930MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Aspartyl/asparaginyl beta-hydroxylase(Asph),partial,Yeast
  • 貨號：
    CSB-EP803930MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Aspartyl/asparaginyl beta-hydroxylase(Asph),partial,Yeast
  • 貨號：
    CSB-BP803930MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Aspartyl/asparaginyl beta-hydroxylase(Asph),partial,Yeast
  • 貨號：
    CSB-MP803930MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Asph
  • Uniprot No.：
  • 別名：
    Asph; BahAspartyl/asparaginyl beta-hydroxylase; EC 1.14.11.16; Aspartate beta-hydroxylase; ASP beta-hydroxylase; Peptide-aspartate beta-dioxygenase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.
  • 基因功能參考文獻(xiàn)：
    1. Results predict that junctin ablation, or mutations that alter its structural attributes, may mimic the etiology of catecholaminergic polymorphic ventricular tachycardia by causing enhanced diastolic Ca2+ leak in the presence of beta-adrenergic activation. PMID: 22025663
    2. in skeletal muscle the disruption of Tdn/CASQ link has a more profound effect on jSR architecture and myoplasmic Ca(2+) regulation than Jct/CASQ association. PMID: 22768324
    3. Ca(2+) and JNT-dependent disassembly of the CSQ2 polymer PMID: 22123818
    4. junctate may play an important role in the regulation of sarcoplasmic reticulum Ca(2+) cycling through the interaction with SERCA2a in the murine heart. PMID: 19896466
    5. evaluation of role in vivo PMID: 11773073
    6. Cardiac remodeling and atrial fibrillation in transgenic mice overexpressing junctin PMID: 12154005
    7. To gain more insight into the underlying mechanisms of impaired contractile relaxation in transgenic mice with cardiac-specific overexpression of junctin (TG), we studied cellular Ca(2+) handling in these mice. PMID: 16289269
    8. Junctin is an essential regulator of sarcoplasmic reticulum Ca release and contractility in normal hearts. Ablation of junctin is associated with aberrant Ca homeostasis, which leads to fatal arrhythmias PMID: 17224479
    9. Data suggest that junctate over-expression is associated with an increase in the sarcoplasmic reticulum Ca2+ storage capacity and releasable Ca2+ content and support a physiological role for junctate in intracellular Ca2+ homeostasis. PMID: 17516551
    10. review of recent findings concerning the expressional regulations and the proposed functions of junctin and junctate PMID: 17706594
    11. Junctate-1 in the heart is closely linked to the homeostasis of E-C coupling proteins and a sustained increase of junctate-1 expression leads to a severe cardiac remodeling and arrhythmias. PMID: 18353357
    12. involved in maintaining sarcoplasmic reticulum Ca2+ store size in skeletal myotubes PMID: 18620751
    13. Partial downregulation of junctin enhances cardiac calcium cycling without eliciting ventricular arrhythmias in mice. PMID: 19286959
    14. analysis of aspartyl (asparaginyl) beta-hydroxylase monoclonal antibodies PMID: 19663697

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  • 亞細(xì)胞定位：
    [Isoform 1]: Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Isoform 2]: Sarcoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Aspartyl/asparaginyl beta-hydroxylase family
  • 組織特異性：
    Isoform 1 is detected in heart, liver and ovary (at protein level). Detected in heart ventricle. Isoform 1 is widely expressed. Isoform 2 is detected in heart and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：