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Recombinant Mouse Cerebellin-4 (Cbln4)

  • 中文名稱：
    Recombinant Mouse Cerebellin-4(Cbln4),Yeast
  • 貨號：
    CSB-YP805305MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cerebellin-4(Cbln4),Yeast
  • 貨號：
    CSB-EP805305MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cerebellin-4(Cbln4),Yeast
  • 貨號：
    CSB-EP805305MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Cerebellin-4(Cbln4),Yeast
  • 貨號：
    CSB-BP805305MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Cerebellin-4(Cbln4),Yeast
  • 貨號：
    CSB-MP805305MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cbln4
  • Uniprot No.：
  • 別名：
    Cbln4; Cblnl1Cerebellin-4; Cerebellin-like glycoprotein 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    25-198
  • 氨基酸序列
    QNDTEP IVLEGKCLVV CDSNPATDSK GSSSSPLGIS VRAANSKVAF SAVRSTNHEP SEMSNKTRII YFDQILVNVG NFFTLESVFV APRKGIYSFS FHVIKVYQSQ TIQVNLMLNG KPVISAFAGD KDVTREAATN GVLLYLDKED KVYLKLEKGN LLGGWQYSTF SGFLVFPL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for the formation and maintenance of inhibitory GABAergic synapses. Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons. May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors. May play a role in CBLN3 export from the endoplasmic reticulum and secretion.
  • 基因功能參考文獻：
    1. Cbln2 and Cbln4 are expressed in distinct MHb neurons that contribute to different behaviors. PMID: 30287486
    2. Results show that Cbln1, Cbln2, and Cbln4 are abundantly expressed in nearly all brain regions, but exhibit strikingly different expression patterns and developmental dynamics. Using newly generated knockin reporter mice for Cbln2 and Cbln4, we find that Cbln2 and Cbln4 are not universally expressed in all neurons, but only in specific subsets of neurons. PMID: 28714144
    3. It is a synaptic protein, enhances inhibitory activity and resistance of neurons to amyloid-beta toxicity. PMID: 25534236
    4. that neurons expressing Cblns 1, 2, and 4 tend to occupy different laminar positions within the dorsal spinal cord PMID: 23853053
    5. SRY and SOX9 contribute to the male-specific upregulation of Cbln4 in the developing testis. PMID: 19211811

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  • 亞細胞定位：
    Secreted. Cell junction, synapse.
  • 組織特異性：
    Expressed in brain with high levels in particular thalamic nuclei. In the thalamus, predominantly expressed in neurons within the parafascicular nucleus. Found in the hippocampus, mostly in the dendrites and somata of pyramidal neurons (at protein level).
  • 數(shù)據(jù)庫鏈接：