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Recombinant Mouse Gamma-synuclein (Sncg)

  • 中文名稱：
    Recombinant Mouse Gamma-synuclein (Sncg)
  • 貨號：
    CSB-EP5197MO
  • 規(guī)格：
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    Sncg
  • Uniprot No.：
  • 別名：
    Persyn
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length
  • 來源：
    E.coli
  • 分子量：
    20.2 kDa
  • 表達(dá)區(qū)域：
    1-123aa
  • 氨基酸序列
    MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGTKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVANKTVEEAENIVVTTGVVRKEDLEPPAQDQEAKEQEENEEAKSGED
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白標(biāo)簽：
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.
  • 基因功能參考文獻(xiàn)：
    1. results indicate that gamma-synuclein is capable of binding to synaptic vesicles, but the mechanism of its interaction with these structures is fundamentally different from the mechanism proposed for alpha-synuclein PMID: 24993968
    2. The results of this study suggested that gamma-synuclein is directly involved in the regulation of cognitive functions. PMID: 23672583
    3. gamma-Synuclein binds synaptic vesicles but is unable to rescue the phenotype of CSPalpha-deficient mice. PMID: 23129765
    4. gamma-synuclein is a regulator of lipid handling in adipocytes, the function of which is particularly important in conditions of nutrient excess PMID: 23213245
    5. Synuclein-alpha, -beta, and -gamma are important in regulating neurotransmitter release from specific populations of midbrain dopamine neurons through mechanisms that differ from those reported in other neurons. PMID: 21593311
    6. The loss of gamma-synuclein results in a significant increase in the level of orientation response in novel environment and decrease in the level of state anxiety. PMID: 21469331
    7. gamma-Synuclein is necessary for the increased Mac-2 expression by myelination-transition-zone astrocytes during glaucoma. PMID: 21199938
    8. The effects of gamma-synuclein deficiency on motor and peripheral sensory neurons were studied. Gamma-synuclein is dispensable for the development and function of the nervous system. PMID: 14585981
    9. Immunohistochemistry demonstrates accelerated accumulation of gamma-synuclein in gracile axonal dystrophy mice. Gamma-synuclein appears in the gracile nucleus at 3 weeks of age and was maintained until 32 weeks. PMID: 15306232
    10. These data indicate the chaperone activity of SNCG on stimulation of steroid receptor signaling in mammary gland. PMID: 17016445
    11. Groups of genes that were similarly altered in SNCA deficient and SNCG deficient mice, leading to nerve degeneration. PMID: 17318638
    12. Together, our data suggest an early role for SYN and inflammation in PD pathogenesis. PMID: 17537546
    13. loss of both alpha- and gamma-synuclein causes an increase in release probability from dopaminergic synapses PMID: 18333965
    14. Mice expressing high levels of gamma-synuclein develop severe and fatal neurological disease. PMID: 19246516

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  • 亞細(xì)胞定位：
    Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    Synuclein family
  • 組織特異性：
    Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. Expressed predominantly in the cell bodies and a
  • 數(shù)據(jù)庫鏈接：