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Recombinant Mouse Gamma-taxilin (Txlng)

  • 中文名稱：
    小鼠Txlng重組蛋白
  • 貨號：
    CSB-YP803878MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Txlng重組蛋白
  • 貨號：
    CSB-EP803878MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Txlng重組蛋白
  • 貨號：
    CSB-EP803878MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Txlng重組蛋白
  • 貨號：
    CSB-BP803878MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Txlng重組蛋白
  • 貨號：
    CSB-MP803878MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Txlng
  • Uniprot No.：
  • 別名：
    Txlng; Lrg; Gamma-taxilin; Factor inhibiting ATF4-mediated transcription; FIAT; Lipopolysaccharide-responsive gene protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-524
  • 氨基酸序列
    MATRLEEVTR GRGGGTEEAS EGGRGGRRRS PPQKFEIGTM EEARICGLGV KADMVCNSQA NDILQHQDPS CGGTTKKHSL EGDEGSDFIT KNRNLVSSVF CTQEKREEIP GREARTGPPD GQQDSECSRN KEKTLGKEVL LLMQALNTLS TPEEKLAALC KKYADLLEES RNVQKQMKIL QKKQAQIVKE KVHLQSEHSK AILARSKLES LCRELQRHNK TLKEENMQQA REEEERRKEA TAHFQITLNE IQAQLEQHDI HNAKLRQENI ELGEKLKKLI EQYALREEHI DKVFKHKELQ QQLVDAKLQQ TTQLIKEADE KHQREREFLL KEATESRHKY EQMKQQEVQL KQQLSLYMDK FEEFQTTMAK SNELFTTFRQ EMEKMTKKIK KLEKETIIWR TKWENNNKAL LQMAEEKTVR DKEYKAFQIK LERLEKLCRA LQTERNELNE KVEVLKEQVS IKAADGDLVS PATQPCAVLD SFKETSRRTL GMHLEARAKS VCEKSAAQKP SSSGSPAQGI ESVD
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.
  • 基因功能參考文獻(xiàn)：
    1. negative regulator of bone mass acting distinctly on bone formation without alteration in resorption and affecting both the trabecular and the cortical compartments PMID: 27906582
    2. We propose that maximal transcriptional repression by FIAT requires its interaction with SUMOylated, HDAC2-interacting aNAC PMID: 24375853
    3. The bone phenotype of compound Naca(+/-); Fiat(+/-) heterozygotes confirms that FIAT and alphaNAC are part of a common genetic pathway and support a role for the FIAT/alphaNAC interaction in normal bone physiology. PMID: 24440290
    4. an interplay between Sp1 and Sp3 as a mechanism involved in the control of Fiat gene expression in osteoblasts. PMID: 23463631
    5. FIAT can both modulate early osteoblast activity by interacting with ATF4 and regulate later osteoblast function through inhibition of FRA-1. PMID: 20392257
    6. Upregulation of MLrgW and MLrgS may be an important component of the LPS inflammatory pathway and of the host response to infection with gram-negative bacteria . PMID: 19913514
    7. These results show that FIAT regulates bone mass accrual and establish FIAT as a novel transcriptional regulator of osteoblastic function.(FIAT protein, mouse) PMID: 15911876
    8. inhibition of FIAT expression increases ATF4 activity and confirm the important role of FIAT in osteoblast function PMID: 19016261

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  • 亞細(xì)胞定位：
    Nucleus membrane. Cytoplasm, cytosol.
  • 蛋白家族：
    Taxilin family
  • 數(shù)據(jù)庫鏈接：