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  4. Recombinant Mouse Homeobox protein MSX-1 (Msx1)

Recombinant Mouse Homeobox protein MSX-1 (Msx1)

  • 中文名稱：
    小鼠Msx1重組蛋白
  • 貨號：
    CSB-YP015068MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Msx1重組蛋白
  • 貨號：
    CSB-EP015068MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Msx1重組蛋白
  • 貨號：
    CSB-EP015068MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Msx1重組蛋白
  • 貨號：
    CSB-BP015068MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Msx1重組蛋白
  • 貨號：
    CSB-MP015068MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Msx1
  • Uniprot No.：
  • 別名：
    Msx1; Hox7; Hox7.1; Homeobox protein MSX-1; Homeobox protein Hox-7; Hox-7.1; Msh homeobox 1-like protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-303
  • 氨基酸序列
    MAPAAAMTSL PLGVKVEDSA FAKPAGGGVG QAPGAAAATA TAMGTDEEGA KPKVPASLLP FSVEALMADH RKPGAKESVL VASEGAQAAG GSVQHLGTRP GSLGAPDAPS SPRPLGHFSV GGLLKLPEDA LVKAESPEKL DRTPWMQSPR FSPPPARRLS PPACTLRKHK TNRKPRTPFT TAQLLALERK FRQKQYLSIA ERAEFSSSLS LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPPAA FGLSFPLGGP AAVAAAAGAS LYSASGPFQR AALPVAPVGL YTAHVGYSMY HLT
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis.
  • 基因功能參考文獻(xiàn)：
    1. Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development. PMID: 27917906
    2. Full digit tip was regenerated only in the MSX1/2 group and was related to boosted Bmp4, Fgf8, and K14 gene expression and to limb-patterning properties resulting from Msx1 and Msx2 overexpression. PMID: 28461333
    3. endocytic adaptor protein Numb regulates the balance between neural and non-neural fates in Msx1 progenitors. PMID: 28011038
    4. these data reveal a novel mechanism that the Bmp4-Msx1 pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt antagonists. PMID: 27713059
    5. Msx1 and Msx2 are expressed both in Primordial germ cell precursors and in neighboring somatic cells. Msx1(-/-); Msx2(-/-) mutant embryos have defects in Primordial germ cell migration as well as a reduced number of Primordial germ cells. PMID: 27435625
    6. Functional analysis of each TE revealed step-by-step retroposition/transposition and co-option together with acquisition of a binding site for Msx1 for its full enhancer function during mammalian evolution. PMID: 27741242
    7. Data show that the spatiotemporal expression of claudin-1 is dysregulated in homeobox (Msx) genes Msx1d/d/Msx2d/d uteri. PMID: 26667042
    8. MSX1 linked the arterial shear stimulus to arteriogenic remodeling by activating the endothelial but not medial layer to a proinflammatory state because EC but not smooth muscle cell PMID: 26391659
    9. findings highlight an unexpected role of uterine Msx in limiting aberrant inflammatory responses to maintain embryonic diapause PMID: 25931120
    10. Msx1 and Msx2 are direct transcriptional targets of Lhx2. PMID: 25460335
    11. Msx1 appears to act as a modeling factor for membranous bone. PMID: 24929242
    12. analysis of a BMP signaling pathway that regulates the expression of the odontogenic gene Msx1 and determines the fate of dental mesenchyme during early tooth development PMID: 25274628
    13. Msx1 supports vascular mineralization by directing the osteogenic programming of aortic progenitors in diabetic arteriosclerosis. PMID: 25056439
    14. Msx1 and Msx2 proteins activate Atoh1 transcription by specifically interacting with several homeodomain binding sites in the Atoh1 3' enhancer. PMID: 24715462
    15. Study concludes that MSX1 may promote proliferation and prevent the differentiation of dental mesenchymal cells by the inhibition of Bmp2 and Bmp4 expression. PMID: 24028588
    16. Msx1 functions as a negative regulator early in pituitary development by repressing the gonadotrope-specific alphaGSU and GnRHR genes. PMID: 23371388
    17. Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development. PMID: 23720046
    18. Differential homeobox expression contributes to phenotypic differences between healthy and atherosclerotic blood vessels. PMID: 23448971
    19. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. PMID: 23506836
    20. Bmp4 signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including Dkk2 and Osr2, and synergizes with Msx1 to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation PMID: 23250216
    21. Msx1 and Msx2 are critical for epithelial-mesenchymal interactions during development, and also play crucial roles in embryo implantation. Loss of Msx1/Msx2 expression correlates with altered uterine luminal epithelial cell polarity. PMID: 22100262
    22. PIAS1 negatively regulates ubiquitination of Msx1 homeoprotein independent of its SUMO ligase activity. PMID: 21717107
    23. Upon meiosis initiation, Msx1 and Msx2 genes were strongly expressed in the fetal ovary. In Msx1/Msx2 double mutant embryos, there was a decrease in the number of meiotic cells. PMID: 22071108
    24. Disturbance of the balance between Msx1 sense and antisense RNA status may be associated with tooth agenesis and bone loss. PMID: 21625063
    25. Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. PMID: 21777520
    26. Study demonstrate that mesenchymal expression of Msx1 and Msx2 is required for proper Shh and Bmp4 signaling to specify digit number and identity. PMID: 21465616
    27. Both Msx1 and Msx2 are required for the recruitment of a population of neural crest-derived vascular smooth muscle cells. PMID: 21693521
    28. Mice lacking both Osr2 and Pax9 exhibited early tooth developmental arrest with significantly reduced Bmp4 and Msx1 mRNA expression in the developing tooth mesenchyme. PMID: 21420399
    29. The Tgf-beta(3) null mutant mouse palate presents several cellular anomalies that lead to the appearance of cleft palate reveals misexpression of EGF and Msx-1. PMID: 20881363
    30. MSX1 and TGF-beta3 are direct targets of FOXE1. PMID: 21177256
    31. Msx1/Dlx5 interaction is crucial for osteogenic induction during frontal bone development. PMID: 20824629
    32. Msx1 is expressed in the cardiac cushions but not in the myocardium. In Msx2-null mice, Msx1 is not ectopically expressed in the myocardium. PMID: 20225205
    33. Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head. PMID: 20398647
    34. Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. PMID: 20123092
    35. Msx1 controls a genetic hierarchy involving BMP and Shh signals that regulates the growth of the anterior region of palate during mammalian palatogenesis PMID: 12163415
    36. Msx1 homeogene antisense mRNA in mouse dental and bone cells. PMID: 12489151
    37. Results demonstrated unimpaired auditory function in Msx1 or 2 (-/-) mice, and suggest that the malleal processus brevis is not necessary for sound transmission and seems dispensable for normal hearing and balance in mammals. PMID: 12701100
    38. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. PMID: 12941628
    39. These data identify a signaling pathway essential for digit regeneration, in which Msx1 functions to regulate BMP4 production. PMID: 12944425
    40. Ectopic expression of Bmp4 in Msx1 mutants restores the expression of Dlx5, but not Cbfa1, in the dental mesenchyme, and rescues the expression of both Dlx5 and Cbfa1 in the developing alveolar bone PMID: 14654219
    41. Msx1 and Msx3 can mediate distinct aspects of Bmp signaling during neural tube development PMID: 14973289
    42. Msx1 disruption leads to diencephalon defects and hydrocephalus. PMID: 15188430
    43. Msx1 and histone H1b bind to a key regulatory element of MyoD, a central regulator of skeletal muscle differentiation, where they induce repressed chromatin; Msx1 and H1b cooperate to inhibit muscle differentiation in cell culture PMID: 15192231
    44. Study of Msx1 null mutant mice concludes that Msx1 is necessary for the synthesis of subcommissural organ glycoproteins, which would then be required for maintenance of an open cerebral aqueduct. PMID: 15217086
    45. Msx1 may be associated with homeostasis and blood-brain barrier function in the adult mouse brain. PMID: 15312901
    46. MSX and DLX have roles in contributing to spatiotemporal regulation of GnRH transcription during development PMID: 15743757
    47. These findings indicate that Msx1 and Msx2 play roles in concert during embryonic ventral abdominal wall formation. PMID: 15803476
    48. plays a role in crucial processes during limb morphogenesis along all three axes PMID: 15930102
    49. Data show that GRG proteins, including GRG5, interact with two regulators of GnRH transcription, the homeodomain proteins MSX1 and OCT1, and regulate GnRH promoter activity. PMID: 16002402
    50. BMP2/BMP4 signalling through SMAD 8 is required for transcriptional activation of the mouse Msx1 gene. PMID: 16101586

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Msh homeobox family
  • 數(shù)據(jù)庫鏈接：