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  4. Recombinant Mouse Immunoglobulin-binding protein 1 (Igbp1)

Recombinant Mouse Immunoglobulin-binding protein 1 (Igbp1)

  • 中文名稱：
    小鼠Igbp1重組蛋白
  • 貨號(hào)：
    CSB-YP720243MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Igbp1重組蛋白
  • 貨號(hào)：
    CSB-EP720243MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Igbp1重組蛋白
  • 貨號(hào)：
    CSB-EP720243MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Igbp1重組蛋白
  • 貨號(hào)：
    CSB-BP720243MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Igbp1重組蛋白
  • 貨號(hào)：
    CSB-MP720243MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Igbp1; Pc52Immunoglobulin-binding protein 1; Alpha4 phosphoprotein; CD79a-binding protein 1; Lymphocyte signal transduction molecule alpha 4; Protein phosphatase 2/4/6 regulatory subunit; p52
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-340
  • 氨基酸序列
    MAASEDELLL PRLPELFETS KKLLEDVEVA TEPTGSRTIQ DKVSKGLELL EKAAGMLSQL DLFSRNEDLE EIASTDLKYL MVPALQGALT MKQVNPSKRL DHLQRAREHF VHFLTQCHCY HVAEFQLPQT KTNSAENNTA SSSMAYPNLV AMASQRQAKI ERYKQKKEVE HRLSALKSAV ESGQADDERV REYHLLHLRR WIAVSLEELE SIDQEIKILK EKDSPREETA CHSSLPEKPP MKPFILTRNK AQAKVFGTGY PSLATMTVSD WYEQHQKYGV LPDRGIAKPA SADFQRAAQQ QEDQEQKDEE SEEKALHRMR EWDDWKDTHP RGYGNRQNMG
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.
  • 基因功能參考文獻(xiàn)：
    1. Report the significance and altered activity of the type 2A protein phosphatase-alpha4 complex in healthy and hypertrophied myocardium. PMID: 28526910
    2. both the C-terminal Mid1-binding domain and the PP2Ac-binding determinants are required for Alpha4-mediated protection of PP2Ac from polyubiquitination and degradation. PMID: 21454489
    3. results show that alpha4, a noncatalytic subunit of protein phosphatase 2A, is required to repress apoptosis in murine cells PMID: 15499020
    4. alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A and PP6 PMID: 16895907
    5. Alpha4 (Igbp1) plays a required role in regulating the assembly and maintenance of adaptive PP2A phosphatase complexes. PMID: 19818709

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    IGBP1/TAP42 family
  • 組織特異性：
    Expressed in spleen, thymus, liver and brain. Ubiquitously expressed in B lineage cell lines.
  • 數(shù)據(jù)庫(kù)鏈接：