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  4. Recombinant Mouse Low affinity immunoglobulin gamma Fc region receptor II (Fcgr2), partial

Recombinant Mouse Low affinity immunoglobulin gamma Fc region receptor II (Fcgr2), partial

  • 中文名稱：
    小鼠Fcgr2重組蛋白
  • 貨號：
    CSB-YP362325MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Fcgr2重組蛋白
  • 貨號：
    CSB-EP362325MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Fcgr2重組蛋白
  • 貨號：
    CSB-EP362325MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Fcgr2重組蛋白
  • 貨號：
    CSB-BP362325MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Fcgr2重組蛋白
  • 貨號：
    CSB-MP362325MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Fcgr2
  • Uniprot No.：
  • 別名：
    Fcgr2; Fcgr2b; Ly-17; Low affinity immunoglobulin gamma Fc region receptor II; Fc gamma receptor IIB; Fc-gamma RII; Fc-gamma-RIIB; FcRII; IgG Fc receptor II beta; Lymphocyte antigen 17; Ly-17; CD antigen CD32
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively.
  • 基因功能參考文獻：
    1. Neuro-inflammation following brain viral infection increases expression of activating Fcgr2b on M1-polarized microglia. PMID: 28165503
    2. Although enhanced humoral immune responses were observed in the absence of FcgammaRIIIA in the mouse asthma model, no overall regulation by FcgammaRIIIA, especially in terms of those parameters measuring lung tissue inflammation, was recorded. In the absence of FcgammaRIIB, augmented immune responses measured as serum antibody levels as well as those in various regulatory pathways in this mouse asthma model were observed. PMID: 29597194
    3. the present data demonstrated that FcgammaRIIb inhibited TLR4 signaling in B cells by activating Lyn phosphorylation and by inhibiting NFkappaBeta signaling. The present study elucidated the mechanism associated with the TLR4 and FcgammaRIIb crosstalk in B cells. PMID: 28849025
    4. Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils PMID: 27999175
    5. PLCd1 negatively regulates lipopolysaccharide-induced production of IL-1b and Fc gamma receptor-mediated phagocytosis in macrophages. PMID: 26643908
    6. The authors concluded that the FcgammaRIIb-SHIP2 axis links Abeta neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease. PMID: 27834631
    7. This study reports the creation of a mouse model of autoimmunity-associated atherosclerosis by transplanting bone marrow from FcgammaRIIB knockout (FcRIIB(-/-)) mice into LDL receptor knockout mice. PMID: 26891734
    8. These results reveal a novel and unexpected function of hepatic Fc-gamma-RIIB in the targeted downregulation of GPVI in vivo. PMID: 27297794
    9. Collectively these findings reveal that by inhibiting eNOS, endothelial FcgammaRIIB activation by CRP blunts insulin delivery to skeletal muscle to cause insulin resistance. PMID: 27207525
    10. Macrophages' activating FcgammaR expression profile are associated with the development of ITP in Treg-deficient mice. PMID: 28028748
    11. this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1/2 and Inpp4a, and accelerates phagosome acidification PMID: 28409542
    12. FcgammaRIIB role in the regulation of mesenchymal stem cell function PMID: 26941575
    13. CD32 is a crucial regulator of FVIII-specific B cells and is required for the differentiation of memory B cells into antibody-secreting cells. PMID: 26245154
    14. Aggregated alpha-Synuclein (alpha-syn) inhibited microglial phagocytosis. The inhibitory effect of aggregated alpha-syn on microglial phagocytosis was due to the activation of SHP-1 and FcgammaRIIB on microglia. PMID: 26342897
    15. Inducing expression of FCGIIB receptors by adipose-derived stem cells attenuated collagen antibody-induced autoimmune arthritis. PMID: 26210906
    16. Fcgr2b(-/-) mice lose bone upon the onset of a hypergammaglobulinemia or the administration of IgG1 immune complexes. PMID: 25824719
    17. IgG (FcgammaR) IIb is involved in the suppressive effect of immune complex on TLR9-mediated CD40, CD80 and IL-6 expression. PMID: 25557539
    18. these studies demonstrate for the first time the ability of FcgammaRIIB to regulate vaccine-induced IgA production and downmodulate immunity and protection. PMID: 25961064
    19. This inhibitory receptor present on dendritic cells, neutrophils, and B cells has an important role in controlling anti-myeloperoxidase autoimmunity and limiting pathological effector responses and glomerular disease. PMID: 24869670
    20. Deletion of FcgammaRIIb/ApoE induces an anti-inflammatory Treg/macrophage polarization that is atheroprotective. PMID: 25516435
    21. Fcgamma-RII and Fcgamma-RIII might participate in the uptake and/or transport of IgG through the intestinal epithelia of adult mice. PMID: 25904149
    22. Aging Siglec-G-deficient and Siglec-G 3/FcgammaRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis. PMID: 25987743
    23. The combined effects of RIIB deletion and pathogenic SLAM can lead to severe lupus nephritis in the B6 genetic background. PMID: 25339546
    24. CRP-induced hypertension in the mouse is fully dependent on FcgammaRIIB. In diet-induced obesity, obese FcgammaRIIB+/+ mice developed hypertension, obese FcgammaRIIB-/- mice were fully protected from hypertension. PMID: 25368023
    25. 12-LOX has an essential role in regulating FcgammaRIIa-mediated platelet function PMID: 25100742
    26. These results suggest that respiratory syncytial virus persistence in macrophages induce intracellular effects that have an impact on Fcgamma receptor gene expression at both mRNA and protein levels. PMID: 24509813
    27. FcgammaRIIb on myeloid cells rather than on B cells protects from collagen-induced arthritis. PMID: 24842758
    28. Data indicate that selective deletion of FcgammaRIIB expression in B cells and dendritic cells (DCs) have increased Ab and T cell responses, respectively. PMID: 24563255
    29. Broad requirement for terminal sialic acid residues and FcgammaRIIB for the preventive and therapeutic activity of intravenous PMID: 24505033
    30. memory CD8 T cells intrinsically express a functional FcgammaRIIB, permitting Ag-Ab complexes to regulate secondary CD8 T cell responses. PMID: 24285839
    31. Our findings clearly indicate that FcRbeta negatively regulates arthritic inflammation in an experimental arthritis model. PMID: 23053716
    32. FcgammaRIIB expression on B cells, in addition to dendritic cells, is important for mucosal induction of Ag-specific immune tolerance. PMID: 24038083
    33. increased expression of both FcgammaRIIa and the common gamma subunit following Pam2CSK4 treatment. Interestingly however, expression of the inhibitory receptor FcgammaRIIb was also modestly increased. PMID: 23504312
    34. Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcgammaRIIb expression and monocyte homeostasis. PMID: 23341540
    35. Immune complex-mediated co-ligation of the BCR with FcgammaRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus. PMID: 22647731
    36. This study demonistrated that the gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia in mouse. PMID: 23186369
    37. How does C-reactive protein (CRP) action via Fcgr2b alter insulin resistance? Data suggest that CRP alters insulin resistance in microvascular endothelium of skeletal muscle via Fcgr2b-mediated inhibition of glucose delivery to muscle. PMID: 23069625
    38. Mice lacking FcgammaRIIb on myeloid cells have exacerbated glomerulonephritis and glomerular neutrophil infiltration when compared with wild-type littermate controls. PMID: 23203925
    39. Immunomodulation of FcgammaRIIb in clinical transplantation may hold potential for inhibiting progression of transplant arteriopathy and prolonging transplant survival. PMID: 23150718
    40. Our findings reveal a fine-tuning system for regulating mast cell apoptosis through aggregating FcgammaRIIB and Fcgamma RIIIA receptors by IgG immune complexes. PMID: 22845035
    41. Natural variation in Fcgr2b drives the development of autoimmune disease. PMID: 23109709
    42. RIIb on LSEC, a major scavenger, keeps SIC blood concentrations low and minimizes pathologic deposition of inflammatory immune complex PMID: 23053513
    43. Mouse basophils coexpress FcgammaRIIIA and FcgammaRIIB receptors; Fcgamma receptors modulate immunoglobulin (Ig)E-induced responses in both human and murine basophils. PMID: 22908332
    44. FcgammaRIIb controls peritoneal B1-type cell survival through an axis modulated by B-cell activating (BAFF) cytokine signaling. PMID: 22516957
    45. Data indicate that Fcgr2b deficiency on either B cells or a subset of myeloid cells alone is not sufficient to increase susceptibility to anti-GBM disease. PMID: 22244885
    46. FcgammaRIIB-deficient mice, generated by gene targeting in C57BL/6 strain-derived embryonic stem cells, exhibit a hyperactive phenotype but fail to develop lethal lupus nephritis PMID: 21724994
    47. expression of Aim2 protein is required to maintain the expression of the Fcgr2b gene and also predict epistatic interactions between the Ifi200 genes and the Fcgr2b gene within the Nba2 interval PMID: 21551362
    48. Ovalbumin-specific IgG ameliorates allergic airway inflammation via FcgammaRIIB on dendritic cells. PMID: 21477339
    49. Co-engagement of BCR and FcgammaRIIb augments the formation of ternary Dok-3/Grb2/SHIP protein complexes. PMID: 21262349
    50. found that immune complexes/Ig markedly inhibited LPS- or CpG-induced dendritic cell (DC) maturation, enhanced tolerogenicity of DCs via FcgammaRIIb PMID: 21360699

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Isoform IIB1]: Cytoplasm, cytoskeleton. Note=Binds the cytoskeleton and is not localized in endocytotic pits.; [Isoform IIB3]: Secreted. Note=Released as a soluble molecule.
  • 組織特異性：
    Widely expressed by cells of hemopoietic origin. The isoforms are differentially expressed. Isoform IIB1 is preferentially expressed by cells of the lymphoid lineage, isoform IIB2 by cells of the myeloid lineage, and isoform IIB3 is released by macrophage
  • 數(shù)據(jù)庫鏈接：