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  4. Recombinant Mouse Macrophage-stimulating protein receptor (Mst1r), partial

Recombinant Mouse Macrophage-stimulating protein receptor (Mst1r), partial

  • 中文名稱：
    小鼠Mst1r重組蛋白
  • 貨號(hào)：
    CSB-YP737071MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Mst1r重組蛋白
  • 貨號(hào)：
    CSB-EP737071MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Mst1r重組蛋白
  • 貨號(hào)：
    CSB-EP737071MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Mst1r重組蛋白
  • 貨號(hào)：
    CSB-BP737071MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Mst1r重組蛋白
  • 貨號(hào)：
    CSB-MP737071MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Mst1r
  • Uniprot No.：
  • 別名：
    Mst1r; Ron; Stk; Macrophage-stimulating protein receptor; MSP receptor; EC 2.7.10.1; Stem cell-derived tyrosine kinase; p185-Ron; CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
  • 基因功能參考文獻(xiàn)：
    1. RON has a role in cancer-induced bone destruction and osteoporosis PMID: 28123075
    2. this study shows that Ron is expressed in a subpopulation of macrophages during chronic inflammation induced by obesity that exhibit a repair phenotype as determined by the expression of arginase 1 PMID: 27233965
    3. Report Ron receptor-dependent gene regulation of inflammatory/anti-inflammatory gene expression in Kupffer cells during endotoxemia. PMID: 24919612
    4. Ron knockdown further sensitized breast cancer cells to the growth inhibitory effects of vitamin D3, while constitutive activation of beta-catenin reverted the effects of vitamin D3. PMID: 26008979
    5. Studies demonstrate that DEK overexpression, due in part to Ron receptor activation, drives breast cancer progression through the induction of Wnt/beta-catenin signaling. PMID: 24954505
    6. A previously unknown function for the Ron receptor in mediating High Fat Diet-induced obesity and metabolic dysregulation. PMID: 25648832
    7. important functional roles for Ron in inflammatory bowel diseases by regulating healing of the colonic epithelium and by controlling cytokine secretion PMID: 24742989
    8. DC-STAMP, Siglec-15, Tspan7 and Mst1r expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro. PMID: 23945674
    9. Stem cell-derived tyrosine kinase plays a role in regulating macrophage recruitment and activation in the liver following acetaminophen administration and in hepatotoxicity. PMID: 22575169
    10. studies show a critical role for the Ron receptor in the tumor microenvironment, whereby Ron loss in tumor-associated macrophages inhibits prostate cancer cell growth, at least in part, by derepressing the activity of CD8(+) T cells PMID: 23328584
    11. Identify a novel signaling mechanism by which the Ron receptor regulates acute liver failure progression. PMID: 22893465
    12. HGF/c-Met plays a crucial role in host and donor cells of the liver for the cursiv selection of transplanted hepatocytes. PMID: 22287599
    13. Data suggest an important role for beta-catenin downstream of Ron receptor signaling during the development of mammary tumorigenesis. PMID: 22474186
    14. loss of ERalpha on a Ron overexpressing background in mice leads to the development of breast tumors PMID: 22226043
    15. The Ron receptor promotes prostate tumor growth in the TRAMP mouse model. PMID: 21625214
    16. Ron overexpression led to the development of prostate intraepithelial neoplasia (mPIN) with local invasion and was associated with increases in prostate cell proliferation and decreases in cell death. PMID: 22004727
    17. we show that genetic ablation of beta-catenin in Ron-expressing breast cancer cells decreases cellular proliferation in vitro, as well as mammary tumor growth and metastasis PMID: 21423209
    18. Inhibition of TLR4-induced IkappaB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein. PMID: 21078906
    19. Ron impacts the progression of inflammatory immune responses in vivo and further support a role for the Ron receptor and its various forms in liver pathophysiology. PMID: 17008558
    20. Ron overexpression on a Chk2*1100 deletion background accelerates the development of mammary tumors. PMID: 20434834
    21. MSP/STK signaling plays a role in up-regulating macrophage and endothelial cell anti-inflammatory activity during hepatic inflammatory responses PMID: 20453108
    22. Results indicate that Ron plays a critical role in regulation of alveolar macrophage signaling and validates this receptor as a target in TNFalpha-mediated pulmonary pathologies. PMID: 19487969
    23. data demonstrate that the interaction of gp55 with Sf-Stk is dependent on cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk PMID: 20016000
    24. Findings indicate that RON signaling mediates cell survival and in vivo resistance to gemcitabine in pancreatic cancer. PMID: 20103639
    25. Activation of the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase by macrophage-stimulating protein induces arginase activity in peritoneal macrophages. PMID: 11777982
    26. demonstrate that the control of erythroid blast-forming unit cycling is encoded by a gene linked to, but distinct from, Fv2, and suggest that this gene is the dual-specific protein phosphatase Cdc25A PMID: 12411323
    27. Data show that Ron mRNA is expressed by nerve growth factor-dependent sensory and sympathetic neurons and that these neurons survive and grow with macrophage stimulating protein (MSP) at different stages of development. PMID: 12538524
    28. activation of the Ron receptor by may aid in implantation by way of trophoblast function and viability PMID: 12606483
    29. sf-Stk, activated by either point mutation or interaction with SFFV gp55, is sufficient to induce Epo-independent erythroid colonies from both Fv-2-susceptible and -resistant mice but is unable to cause erythroleukemia in Fv-2-resistant mice. PMID: 15078939
    30. Ron receptor can interact with each of the three members of class B Plexins and control tumor invasive growth. PMID: 15184888
    31. Loss of Ron receptor signaling significantly reduced the percent of papillomas that underwent malignant conversion and the number of mice developing other malignant tumor types (Ron receptor) PMID: 15531916
    32. the activated beta-catenin cascade is one of the pathways involved in tumorigenic activities mediated by the oncogenic RON variant PMID: 15878878
    33. The proto-oncogene, c-Cbl, which modulates ubiquitylation of RON, was increased in glia in both multiple sclerosis brains and experimental autoimmune encephalomyelitis spinal cords PMID: 15929040
    34. the ligand-dependent and -independent activity of mRon can be uncoupled through the alteration of selective sets of tyrosines PMID: 16103119
    35. altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity PMID: 16166096
    36. Results suggest that Mst1r signaling may be involved in the regulation of macrophage and T-lymphocyte activation in vivo during injury. PMID: 16166746
    37. Ron is ubiquitylated also by the U-box E3 ligase C-terminal Hsc70-interacting protein (CHIP), recruited via chaperone intermediates Hsp90 and Hsc70 PMID: 16740632
    38. Data demonstrate that Stat3 is required for the erythropoietin-independent growth of Friend virus-infected cells and that the activation of Stat3 by Sf-Stk is mediated by a novel Stat3 binding site in Gab2. PMID: 17353274
    39. Expression of a Cbl-Grb2 chimera rescued impaired cMet endocytosis in cells depleted of endogenous Grb2 PMID: 17449471
    40. RON receptor signaling may contribute to pancreatic carcinogenesis PMID: 17616662
    41. Stk and its downstream effectors are critical to the Friend spleen focus-forming virus transformation in fibroblasts. PMID: 17959667
    42. RON receptor regulates both the production of and response to IFN-gamma, resulting in enhanced susceptibility to endotoxin challenge. PMID: 18684919
    43. Microarray analysis of pubertal RonTK-/- glands revealed 393 genes temporally impacted by Ron expression with significant changes observed in signaling networks regulating development, morphogenesis, differentiation, cell motility, and adhesion. In PMID: 19576199

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family
  • 組織特異性：
    Expressed in liver, skin, lung, brain, testis and kidney.
  • 數(shù)據(jù)庫(kù)鏈接：