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  4. Recombinant Mouse NACHT, LRR and PYD domains-containing protein 10 (Nlrp10)

Recombinant Mouse NACHT, LRR and PYD domains-containing protein 10 (Nlrp10)

  • 中文名稱：
    小鼠Nlrp10重組蛋白
  • 貨號：
    CSB-YP804485MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Nlrp10重組蛋白
  • 貨號：
    CSB-EP804485MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Nlrp10重組蛋白
  • 貨號：
    CSB-EP804485MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Nlrp10重組蛋白
  • 貨號：
    CSB-BP804485MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Nlrp10重組蛋白
  • 貨號：
    CSB-MP804485MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Nlrp10
  • Uniprot No.：
  • 別名：
    Nlrp10; Nalp10; Pynod; NACHT; LRR and PYD domains-containing protein 10
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-673
  • 氨基酸序列
    MALARANSPQ EALLWALNDL EENSFKTLKF HLRDVTQFHL ARGELESLSQ VDLASKLISM YGAQEAVRVV SRSLLAMNLM ELVDYLNQVC LNDYREIYRE HVRCLEERQD WGVNSSHNKL LLMATSSSGG RRSPSCSDLE QELDPVDVET LFAPEAESYS TPPIVVMQGS AGTGKTTLVK KLVQDWSKGK LYPGQFDYVF YVSCREVVLL PKCDLPNLIC WCCGDDQAPV TEILRQPGRL LFILDGYDEL QKSSRAECVL HILMRRREVP CSLLITTRPP ALQSLEPMLG ERRHVLVLGF SEEERETYFS SCFTDKEQLK NALEFVQNNA VLYKACQVPG ICWVVCSWLK KKMARGQEVS ETPSNSTDIF TAYVSTFLPT DGNGDSSELT RHKVLKSLCS LAAEGMRHQR LLFEEEVLRK HGLDGPSLTA FLNCIDYRAG LGIKKFYSFR HISFQEFFYA MSFLVKEDQS QQGEATHKEV AKLVDPENHE EVTLSLQFLF DMLKTEGTLS LGLKFCFRIA PSVRQDLKHF KEQIEAIKYK RSWDLEFSLY DSKIKKLTQG IQMKDVILNV QHLDEKKSDK KKSVSVTSSF SSGKVQSPFL GNDKSTRKQK KASNGKSRGA EEPAPGVRNR RLASREKGHM EMNDKEDGGV EEQEDEEGQT LKKDGEMIDK MNG
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. Contributes to T-cell-mediated inflammatory responses in the skin. Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens. Exhibits both ATPase and GTPase activities.
  • 基因功能參考文獻(xiàn)：
    1. Authors observed an important role of NLRP10 in cytokine and chemokine production as well as expression of NF-kappaB and MAPKs in CSE-exposed A549 cells. Furthermore, replenishment of A549 cell culture with recombinant IL-17A (rIL-17A) during NLRP10 knockdown rescued CSE-induced inflammatory responses. PMID: 29501574
    2. this study documented a role for NLRP10 as a suppressor of the cutaneous inflammatory response to Leishmania major infection PMID: 28931602
    3. NLRP10 contributes to T-cell-mediated inflammatory responses in the skin PMID: 27221772
    4. Review summarize recent advances of the role of of human and murine NLRP10 in innate and adaptive immune responses. [Review] PMID: 23562614
    5. Nlrp10-deficient mice displayed a profound defect in Candida-specific Th1 and Th17 responses. These results demonstrate a novel role for Nlrp10 in the generation of adaptive immune responses to fungal infection. PMID: 23071280
    6. loss of antigen transport to the draining lymph nodes by a subset of migratory dendritic cells resulted in an almost absolute loss in naive CD4( ) T-cell priming, highlighting the critical link between diverse innate immune stimulation, NLRP10 activity and the immune function of mature DCs PMID: 22538615
    7. Serum interleukin (IL)-1beta and TNF-alpha after lipopolysaccharide injection are decreased in PYNOD-transgenic and apoptosis-associated speck-like protein containing a caspase recruitment domain knockout mice compared with those of wild-type mice. PMID: 20393137
    8. PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins PMID: 15817483

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    NLRP family
  • 組織特異性：
    Expressed in skin, tongue, heart, colon and several cell lines of hematopoietic and myocytic origin but not in kidney, skeletal muscle, spleen, liver, lung, thymus, brain or small intestine (at protein level).
  • 數(shù)據(jù)庫鏈接：