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  4. Recombinant Mouse Nuclear receptor-interacting protein 1 (Nrip1), partial

Recombinant Mouse Nuclear receptor-interacting protein 1 (Nrip1), partial

  • 中文名稱：
    小鼠Nrip1重組蛋白
  • 貨號：
    CSB-YP804935MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Nrip1重組蛋白
  • 貨號：
    CSB-EP804935MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Nrip1重組蛋白
  • 貨號：
    CSB-EP804935MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Nrip1重組蛋白
  • 貨號：
    CSB-BP804935MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Nrip1重組蛋白
  • 貨號：
    CSB-MP804935MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Nrip1
  • Uniprot No.：
  • 別名：
    Nrip1; Nuclear receptor-interacting protein 1; Nuclear factor RIP140; Receptor-interacting protein 140
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development.
  • 基因功能參考文獻(xiàn)：
    1. Up-regulation of RIP140 promotes glucolipotoxicity-induced damage in pancreatic beta cells. PMID: 29631683
    2. RIP140 is a co-repressor of HSF1, and it regulates neuronal stress response. PMID: 29233969
    3. Data suggests that NRIP1 is overexpressed both in skin and PBMCs of psoriasis patients and may be involved in the abnormal proliferation and apoptosis of keratinocytes. PMID: 27708240
    4. It is able to modulate the transcription of certain genes involved in AD pathology, such as b-APP cleaving enzyme (BACE1) and GSK3. Consequently, we found that RIP140 overexpression reduced the generation of Ab in a neuroblastoma cell line by decreasing the transcription of b-APP cleaving enzyme via a PPARge dependent mechanism. PMID: 27614112
    5. These data indicate that dominant NRIP1 mutations can cause kidney and urinary tract by interference with retinoic acid transcriptional signaling, shedding light on the well documented association between abnormal vitamin A levels and renal malformations in humans, and suggest a possible gene-environment pathomechanism in this disease PMID: 28381549
    6. RIP140 has a unique role in the acute effect of beta-3 adrenergic receptor activation. PMID: 28322782
    7. depletion of receptor-interacting protein 140 could significantly alleviate the inhibitory effects of estrogen on osteoclasts formation and bone resorption activity. PMID: 27016936
    8. Nuclear receptor interacting protein 140 (RIP140) is an identified nuclear receptor corepressor that has been shown to suppress mitochondrial biogenesis in skeletal muscle. PMID: 26360644
    9. Data show that 7,12-dimethylbenzanthracene (DMBA)-induced carcinogenesis is suppressed in nuclear receptor interacting protein 1 (Nrip1) knockout mice. PMID: 26492163
    10. RIP140 plays an important role in maintaining brain cholesterol homeostasis through, partially, regulating cholesterol metabolism in, and mobilization from, astrocyte. PMID: 25697398
    11. RIP140 translocation to the cytoplasm is an early response to ER stress and provides protection against neuronal death. PMID: 25066731
    12. Study revealed an emotional regulatory function of macrophage-derived RIP140 in the VMH, and secondary dysregulation of NPY within hypothalamic astrocyte population, which might be associated with the observed behavioral phenotype of MPhiRIPKD mice. PMID: 24726835
    13. RIP140 knockdown in macrophages led to significant white adipose tissue browning, improved systemic insulin sensitivity, particularly under high fat diet feeding, and an altered adipose tissue macrophage profile. PMID: 24969109
    14. RIP140 blocks the BRITE program in white adipose tissue. PMID: 24479876
    15. RIP140 stimulated APC transcription and inhibited beta-catenin activation and target gene expression. PMID: 24667635
    16. RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals. PMID: 23404106
    17. RIP140 effectively inhibits the proliferation and facilitates the apoptosis of microglioma cells. PMID: 22321934
    18. IGF1 may coregulate female sexual maturation and longevity; wild-derived strains carry specific alleles that delay sexual maturation; and Nrip1 is involved in regulating sexual maturation and may affect longevity by regulating IGF1 level. PMID: 22566614
    19. Findings reinforce the participation of RIP140 in the maintenance of energy homeostasis by acting as an inhibitor of energy production. PMID: 22389706
    20. The RIP140 gene depletion results in learning and memory deficits as well as stress response, bringing to light a major role for this transcriptional coregulator in the neurophysiological developmental mechanisms underlying cognitive functions. PMID: 21906262
    21. Our results identify RelA as an adaptor with which the E3 ligase SCF fine tunes NF-kappaB target genes by targeting the coactivator RIP140 PMID: 22388040
    22. this study reveals a new functional role for cytoplasmic RIP140 in modulating adiponectin vesicle secretion PMID: 21872658
    23. Decreased RIP140 protein content not required for exercise and AMPK-dependent increases in skeletal muscle mitochondrial content. PMID: 21700896
    24. not only involved in metabolic control but also acts as a coactivator for RORalpha, influencing clock gene expression PMID: 21628546
    25. The blocking of cytoplasmic RIP140 accumulation reduces basal and isoproterenol-stimulated lipolysis and the pro-inflammatory potential of their conditioned media. PMID: 21504789
    26. The study uncovers a cholesterol-miR-33-RIP140 regulatory pathway that modulates the proinflammatory potential in macrophages in response to an alteration in the intracellular cholesterol status. PMID: 21285396
    27. a new, cytoplasmic function for RIP140 as a negative regulator of GLUT4 trafficking and glucose uptake PMID: 19945409
    28. Data conclude that although the level of RIP140 expression in the ovary is a crucial for the transient expression of EGF-like factors necessary for cumulus expansion, it also plays a role in other signaling pathways that induce follicular rupture. PMID: 20308529
    29. RIP140 may have a role in retinoic acid mediation of long-paced oscillations in retinoid receptor activity PMID: 19862326
    30. Data demonstrate post-transcriptional regulation of RIP140 mRNA, involving the enhancing effect of a specific mir-346 that targets RIP140's 5'UTR. PMID: 19780716
    31. Data show that a ligand-dependent transcriptional repressor for nuclear receptors, RIP140, plays a crucial role in regulating the balance between energy storage and energy expenditure. PMID: 15155905
    32. important role for RIP140 in the regulation of multiple processes leading to ovulation PMID: 15919748
    33. Reduction in the levels of RIP140 or prevention of its recruitment to nuclear receptors may provide novel mechanisms for the control of energy expenditure in adipose cells. PMID: 16227589
    34. RIP140 is a major suppressor of adipocyte oxidative metabolism and mitochondrial biogenesis, as well as a negative regulator of whole-body glucose tolerance and energy expenditure in mice. PMID: 16374519
    35. regulation of Ucp1 expression in the absence of RIP140 involves derepression of at least three different nuclear receptors PMID: 17456798
    36. the function of RIP140 as a cofactor for LXR in liver varies according to the target genes and metabolic process, serving as a coactivator in lipogenesis but as a corepressor in gluconeogenesis PMID: 17684114
    37. Results demonstrate that the nuclear receptor corepressor RIP140 is a key regulator of metabolism in skeletal muscle. PMID: 17767910
    38. RIP140 serves as a scaffold for both DNA and HMT activities to inhibit gene transcription directing histone and DNA methylation to silence Ucp1 expression in white adipocytes two key epigenetic repression systems PMID: 17972916
    39. Direct transcriptional inhibition of beta-adrenergic-receptor-mediated, cyclic AMP-dependent Ucp1 gene expression involves the differential recruitment of RIP140 to an LXRalpha binding site that overlapping the PPARgamma/PGC-1alpha response element. PMID: 18195045
    40. ability of RIP140 to function as a coactivator for cytokine gene promoter activity relies on direct protein-protein interactions with the NFkappaB subunit RelA and histone acetylase cAMP-responsive element binding protein (CREB)-binding protein (CBP). PMID: 18469200
    41. PKCepsilon stimulates arginine methylation of RIP140 for its nuclear-cytoplasmic export in adipocyte differentiation PMID: 18628823
    42. These results demonstrate the signal transduction pathway, initiated from Erk2 activation for specific threonine phosphorylation, followed by p300 recruitment for lysine acetylation, which ultimately enhances the gene-repressive activity of RIP140. PMID: 18655826
    43. Induction of RIP140 in liver provides a molecular rationale for hepatic steatosis in starvation, sepsis, or cancer cachexia. PMID: 18712775
    44. Results describe the roles of RIP140 and PGC-1alpha in controlling the expression of CIDEA, an important regulatory factor in adipose cell function and obesity. PMID: 18794372
    45. Kinetic analysis of PTMs of endogenous RIP140 in differentiated 3T3-L1 cells demonstrates sequential modifications on RIP140, initiated from constitutive lysine methylation, followed by increased arginine methylation later in differentiation. PMID: 19216533

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed
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