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  4. Recombinant Mouse Plexin-A1 (Plxna1), partial

Recombinant Mouse Plexin-A1 (Plxna1), partial

  • 中文名稱：
    小鼠Plxna1重組蛋白
  • 貨號：
    CSB-YP018217MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Plxna1重組蛋白
  • 貨號：
    CSB-EP018217MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Plxna1重組蛋白
  • 貨號：
    CSB-EP018217MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Plxna1重組蛋白
  • 貨號：
    CSB-BP018217MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Plxna1重組蛋白
  • 貨號：
    CSB-MP018217MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Plxna1; Kiaa4053; Plexin-A1; Plex 1; Plexin-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
  • 基因功能參考文獻(xiàn)：
    1. species-dependent regulation of PlexA1 expression may have been crucial in the evolution of mammalian cortico-motoneuronal systems that improved fine motor control in higher primates. PMID: 28751609
    2. work reveals a 2-fold role of the PlxnA ectodomains: imposing a pre-signaling autoinhibitory separation for the cytoplasmic domains via intermolecular head-to-stalk interactions and supporting dimerization-based PlxnA activation upon ligand binding. PMID: 27397516
    3. PLXNA1 mediates the acquisition of malignant phenotypes induced by autocrine SEMA3A signaling in lung cancer cells. PMID: 27717823
    4. Study showed that progenitor cells lining the telencephalic ventricles express PlexinA1 and that absence of this receptor impairs neurogenesis in the developing forebrain PMID: 25975775
    5. PlexinA1 mediates both Semaphorin and Slit signaling PMID: 25485759
    6. genetic findings demonstrate that Sema3a repellent signaling plays a role in the establishment of proper afferent projections in SAG neurons, and this signaling likely occurs through a receptor complex involving Npn1 and either plexinA1 or plexinA3 PMID: 23991118
    7. A novel direct interaction between the Sema3a signaling receptor plexinA1 and nephrin, linking extracellular Sema3a signals to the slit-diaphragm signaling complex, was identified. PMID: 23954273
    8. These findings suggest a mechanism by which a complex of Sema6D, Nr-CAM, and Plexin-A1 at the chiasm midline alters the sign of Sema6D and signals Nr-CAM/Plexin-A1 receptors on retinal ganglion cells to implement the contralateral retinal cell projection. PMID: 22632726
    9. involved in the entry of dendritic cells into the lymphatics as a principal receptor for semaphorins PMID: 20512151
    10. Results suggest that plexin-A1 and B1 interact in the adult brain and transduce semaphorin 3A signaling in cooperation. PMID: 12559962
    11. Plexin-A1 affects t-cell-dendritic cell interaction but not antigen processing or binding. PMID: 12910265
    12. Plexin signaling uncouples cell substrate-adhesion from cytoskeletal dynamics required for cell migration and axon extension. PMID: 14734633
    13. Plexin-A1 forms a receptor complex with vascular endothelial growth factor receptor type 2 in heart morphogenesis PMID: 14977921
    14. During mouse embryogenesis, the murine ortholog of plexin-A1 gene showed restricted spatial and temporal expression in the hindbrain, consistent with a role in cell body movement, or axonal guidance during facial nerve development. PMID: 15996756
    15. plexin-A1 associates with the triggering receptor expressed on myeloid cells-2 (Trem-2), linking semaphorin-signalling to the immuno-receptor tyrosine-based activation motif (ITAM)-bearing adaptor protein, DAP12 PMID: 16715077
    16. our findings establish a role for plexin A1-mediated axonal exclusion in organizing the projection pattern of spinal sensory afferents PMID: 17145500
    17. There are distinct expression patterns of the individual plexin-A family members suggesting that regenerating rubrospinal and facial motoneurons have a differential ability to transduce semaphorin signals. PMID: 17197097

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Plexin family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：