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  4. Recombinant Mouse Plexin-A4 (Plxna4), partial

Recombinant Mouse Plexin-A4 (Plxna4), partial

  • 中文名稱：
    小鼠Plxna4重組蛋白
  • 貨號(hào)：
    CSB-YP768880MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Plxna4重組蛋白
  • 貨號(hào)：
    CSB-EP768880MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Plxna4重組蛋白
  • 貨號(hào)：
    CSB-EP768880MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Plxna4重組蛋白
  • 貨號(hào)：
    CSB-BP768880MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Plxna4重組蛋白
  • 貨號(hào)：
    CSB-MP768880MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Plxna4
  • Uniprot No.：
  • 別名：
    Plxna4; Kiaa1550; Plexin-A4
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
  • 基因功能參考文獻(xiàn)：
    1. These findings implicate Semaphorin-6A - Plexin-A2/Plexin-A4 interactions in dorsal lateral geniculate nucleus axon guidance and in the spatiotemporal organization of guidepost cell populations in the mammalian subpallium. PMID: 28438183
    2. These findings suggest that by interacting with PlexA4, TrkA plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 localization and patterning. PMID: 26945060
    3. Both CLU and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU-PLXNA4 interactions may have therapeutic value in AD. PMID: 27378688
    4. work reveals a 2-fold role of the PlxnA ectodomains: imposing a pre-signaling autoinhibitory separation for the cytoplasmic domains via intermolecular head-to-stalk interactions and supporting dimerization-based PlxnA activation upon ligand binding. PMID: 27397516
    5. Results suggest that semaphoring 6a activates plexin 4a by disrupting an inhibitory plexin dimer and inducing the active dimer PMID: 26536270
    6. Distinct cytoplasmic domains in Plexin-A4 mediate diverse responses to semaphorin 3A in developing mammalian neurons. PMID: 24619647
    7. results suggest that Plexin-A4 is involved in the precise positioning of oligodendrocyte precursor cells in developing cerebral cortex. PMID: 22516460
    8. null mutations in Sema6A or PlexinA4 (PlexA4) exhibit a pronounced defect in OPL stratification of horizontal cell axons without any apparent deficits in bipolar cell dendrite or photoreceptor axon targeting. PMID: 22593055
    9. Findings suggest plexin-A4 and Sema3A as new intervention points for treating sepsis. PMID: 21098092
    10. It regulates lamina-restricted projection of hippocampal mossy fiber. (review) PMID: 21089322
    11. suggesting that a Semaphorin6A-Plexin-A4 cis interaction serves as an inhibitory mechanism. PMID: 20606624
    12. plexin-A4 was expressed in the developing nervous system with a pattern different to that of other members of the plexin-A subfamily (plexin-A1, plexin-A2 and plexin-A3) PMID: 12591607
    13. PlexA4 expressed in oligodendrocyte precursor cells acts as a mediator of semaphorin signals PMID: 17109816
    14. plexin-A4, as a component of the receptor complex for class III semaphorins, negatively regulates T cell-mediated immune responses PMID: 18209113
    15. plexin-A3 and plexin-A4 are expressed in newly-differentiated sympathetic neurons, but not their neural crest precursors. They function cooperatively to regulate the migration of sympathetic neurons and then differentially to guide the sympathetic axons. PMID: 18262512
    16. These results indicate that the stereotyped pruning of the visual and motor CST axon collaterals is differentially regulated and that this specificity arises from the differential expression of plexin receptors in the cortex. PMID: 18523013
    17. the signaling of plexin-A3, plexin-A4, and Sema6A is at least partially required for dorsal turning of the corticospinal tract axons PMID: 18727829
    18. The combined loss of PLXNA3 and PLXNA4 impaired facial branchiomotor axon guidance more severely than loss of either plexin alone, suggesting that SEMA3A and SEMA3F signals, even though both essential, are partially redundant. PMID: 18804103

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Plexin family
  • 組織特異性：
    Expressed in the developing nervous system. Widely expressed in both the central and peripheral nervous systems. Expressed in the peripheral ganglia, somatosensory, olfactory, visual, auditory and equilibrium systems.
  • 數(shù)據(jù)庫(kù)鏈接：