Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse SH3 and multiple ankyrin repeat domains protein 2 (Shank2), partial

Recombinant Mouse SH3 and multiple ankyrin repeat domains protein 2 (Shank2), partial

  • 中文名稱(chēng)：
    小鼠Shank2重組蛋白
  • 貨號(hào)：
    CSB-YP802258MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    小鼠Shank2重組蛋白
  • 貨號(hào)：
    CSB-EP802258MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    小鼠Shank2重組蛋白
  • 貨號(hào)：
    CSB-EP802258MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    小鼠Shank2重組蛋白
  • 貨號(hào)：
    CSB-BP802258MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    小鼠Shank2重組蛋白
  • 貨號(hào)：
    CSB-MP802258MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Shank2; Cortbp1; Kiaa1022SH3 and multiple ankyrin repeat domains protein 2; Shank2; Cortactin-binding protein 1; CortBP1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
  • 基因功能參考文獻(xiàn)：
    1. The results indicate that SHANK2 is crucial for parallel fiber-Purkinje cell long-term potentiation, but not long-term depression. In addition, SHANK2 is important for intrinsic plasticity of neuronal excitability. PMID: 27581745
    2. location memory acquired in a head-fixed virtual environment. Encoding and updating of virtual cued goal location memory was impaired in Shank2-deficient mice that mimic a deletion found in human autistic patients and exhibit impaired spatial learning in a real environment. These results highlight the roles of the dorsal hippocampus and postsynaptic protein complexes in spatial learning and navigation in virtual reality. PMID: 28484738
    3. Shank2 protein is involved in spinal NMDA receptor-mediated pain, and mutations of Shank2 may suppress NMDA-ERK signaling in spinal pain transmission. PMID: 28326932
    4. We found that Shank2 regulates excitatory synapse density, motor coordination, and specific repetitive and anxiety-like behaviors, but is not associated with autistic-like social deficits or repetitive behaviors. PMID: 27903723
    5. Shank2(-) (/) (-) (Shank2 knock-out, KO) mice to investigate the controversial pain sensitivity issue and found that Shank2 KO mice showed reduced tactile perception and analgesia to chronic pain. PMID: 27145803
    6. trans-synaptic Zn mobilization by clioquinol, a Zn chelator and ionophore, rescues the social interaction deficits in Shank2-/- and Tbr1+/- mice PMID: 25981743
    7. Since mutations in all three human SHANK genes are linked to neuropsychiatric disorders such as autism and schizophrenia, Shank mutant mice serve as corresponding in vivo model systems--{REVIEW} PMID: 25917711
    8. Shank2 appears to be a key molecule regulating epithelial fluid secretion. PMID: 24445315
    9. syndapin I functions reflected direct, SH3 domain-mediated associations and functional interactions with ProSAP1/Shank2. PMID: 24751538
    10. Scaffolding proteins ProSAP1/2 were found within the postsynaptic specializations of synapses within the PNS, indicating a similar molecular assembly of central and peripheral postsynapses. PMID: 20800661
    11. Shank2 negatively regulates CFTR and this may play a significant role in maintaining epithelial homeostasis PMID: 14679199
    12. Data suggest that Shank 2 is expressed in the neurons of the developing retina and could play a critical role in the neuronal differentiation of the developing retina. PMID: 19299912

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Apical cell membrane. Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Cell projection, growth cone.
  • 蛋白家族：
    SHANK family
  • 組織特異性：
    Detected in brain (at protein level), where it is highly expressed in Purkinje cells.
  • 數(shù)據(jù)庫(kù)鏈接：