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  4. Recombinant Mouse Sal-like protein 4 (Sall4), partial

Recombinant Mouse Sal-like protein 4 (Sall4), partial

  • 中文名稱：
    小鼠Sall4重組蛋白
  • 貨號：
    CSB-YP804420MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Sall4重組蛋白
  • 貨號：
    CSB-EP804420MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Sall4重組蛋白
  • 貨號：
    CSB-EP804420MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Sall4重組蛋白
  • 貨號：
    CSB-BP804420MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Sall4重組蛋白
  • 貨號：
    CSB-MP804420MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Sall4
  • Uniprot No.：
  • 別名：
    Sall4; Sal-like protein 4; Zinc finger protein SALL4
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
  • 基因功能參考文獻：
    1. Findings indicate that SALL4 critically contributes to MLL-AF9-induced leukemia, unraveling the underlying transcriptional and epigenetic mechanisms in this disease. PMID: 28974232
    2. SALL4 associated with the NuRD co-repressor and repressed expression of the tumor suppressor genes Foxl1 and Dusp4. PMID: 28867346
    3. Study propose a model whereby enhancer binding by Sall4 and other pluripotency-associated transcription factors is responsible for maintaining the balance between transcriptional programmes in pluripotent cells. PMID: 27471257
    4. SALL4 has a negative impact in DNA damage repair, and support the model of dual functional properties of SALL4 in leukemogenesis through inhibiting DNA damage repair and promoting cell survival. PMID: 27132514
    5. these data reveal the full profile of PLZF and SALL4 regulatory targets in undifferentiated spermatogonia. PMID: 27068105
    6. study explores a pivotal role of Sall4 in regulating epigenetic maturation of mouse oocytes. PMID: 28031467
    7. JARID2 physically interacts with ESRRB, SALL4A, and PRDM14 PMID: 26523946
    8. As SALL4A is known to impair ZBTB16-mediated Kit repression [14], our study provides novel insights into the molecular mechanism by which ATRA could control KIT expression, and thereby the differentiation of Aal into A1 spermatogonia in vivo. PMID: 26427057
    9. In differentiated ESCs, Sall4 bound to these somatic cell program gene loci, which are reportedly occupied by Prdm1 in embryonic carcinoma cells. PMID: 25263278
    10. This study identified a critical role of the Sall4-Gli3 system at the early steps of limb development for proper development of the appendicular skeletal elements. PMID: 25848055
    11. Sall4 also interacts with Baf60a, a member of the SWI/SNF (switch/sucrose nonfermentable) ATP-dependent chromatin-remodeling complex, which is responsible for recruiting Sall4 to the site of DNA DSB damage. PMID: 25733712
    12. SALL4b is the major isoform in hematopoietic stem cells. Overexpression of either isoform impairs hematopoietic colony formation. Lineage-negative bone marrow overexpressing SALL4b fails to engraft. SALL4a or SALL4b overexpression impairs hematopoiesis. PMID: 25246269
    13. our data revealed that histone demethylase LSD1 may negatively regulate SALL4-mediated transcription, and the dynamic regulation of SALL4-associated epigenetic factors cooperatively modulates early hematopoietic precursor proliferation. PMID: 24163373
    14. these results indicate that 1) SALL4 isoforms are differentially expressed at the initiation of spermatogenesis PMID: 23326552
    15. Sall4 contributes to the transcriptional network operating in pluripotent cells together with Oct-3/4 and Sox2 PMID: 23269686
    16. SALL4 and KLF5 were aberrantly expressed in the CDX1(+) intestinal metaplasia of the stomach. Sustained expression of CDX1 gave rise to the induction of early intestinal-stemness markers, followed by the expression of intestinal-differentiation markers. PMID: 23112162
    17. Taking into account the importance of SALL4 for mouse development, we conclude that SALL4 may play an important role during mammalian germ cell development. PMID: 22572102
    18. Plzf antagonizes Sall4 function by displacing Sall4 from cognate chromatin to induce Sall1 expression PMID: 22385656
    19. This work provides further support that Sall4 manipulation may be a new model for expanding clinically transplantable stem cells. PMID: 21943195
    20. Results indicate that the FISH hybrid signal could be detected on mitotic chromosomes in both male and female mice and M. m. mandarinus. PMID: 21756254
    21. Data show that Sall4a and Sall4b have overlapping, but not identical binding sites within the embryonic stem cell genome. PMID: 20837710
    22. SALL4 is a master regulator that controls its own expression and the expression of OCT4. PMID: 20505821
    23. cloning and expression analysis; prominent expression in the developing midbrain, branchial arches and the limbs suggests an important function of SALL4 during development of these structures PMID: 12826753
    24. A positive and negative feed-forward circuit between Tbx5 and Sall4 ensures precise patterning of embryonic limb and heart and provides a unifying mechanism for heart/hand syndromes. PMID: 16380715
    25. SALL4B transgenic mice developed myelodysplastic syndrome (MDS)-like features and subsequently AML that was transplantable. PMID: 16763212
    26. Sall4 and Sall1 form heterodimers, and a truncated Sall1 caused mislocalization of Sall4 in the heterochromatin; thus, some symptoms of Townes-Brocks syndrome caused by SALL1 truncations could result from SALL4 inhibition. PMID: 16790473
    27. Sall4 as an essential transcription factor required for the early development of inner cell mass-derived cell lineages PMID: 17060609
    28. we demonstrate that Sall4 operates as a transcriptional repressor located to heterochromatin and that this activity is modulated by Cyclin D1. PMID: 17383611
    29. Bmi1 is a target gene for Sall4 in hematopoietic cells. PMID: 17557835
    30. the reprogramming activity of Sall4 is independent of an N-terminal domain implicated in recruiting the nucleosome remodeling and deacetylase corepressor complex, a global transcriptional repressor PMID: 18414659
    31. Tetraploid rescue underlined the extra-embryonic nature of the Sall4-1a phenotype and revealed a further embryonic function in Wnt/beta-catenin signaling to elongate the AP axis during gastrulation PMID: 18781635
    32. regulates the key lineage-associated genes Gata4, Gata6, Sox7, and Sox17 in extraembryonic endoderm cells PMID: 18804426
    33. A fundamental and redundant function of the Sall proteins in murine neurulation, is shown. PMID: 18818376
    34. Sall4 plays a diverse role in regulating stem cell pluripotency during early embryonic development through integration of transcriptional and epigenetic controls. PMID: 19060217
    35. Sall4 plays a crucial role in controlling the lineage commitment of hepatoblasts not only inhibiting their differentiation into hepatocytes but also driving their differentiation toward cholangiocytes PMID: 19185577
    36. six genes (Csk, Itga3, Jarid2, Prkaca, Rarg, and Sall4), known to cause NTDs when deleted, that are also down-regulated in p53 -/- embryos. PMID: 19229884
    37. Sall4 does not contribute to the central machinery of the pluripotency, it stabilizes embryonic stem cells by repressing aberrant trophectoderm gene expression. PMID: 19350679
    38. Positevely regulates Oct4 in preimplantation embryos and ES cells through a direct interaction with the Oct4/Pou5f1 promoter. PMID: 16980957

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Sal C2H2-type zinc-finger protein family
  • 數(shù)據(jù)庫鏈接：