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  4. Recombinant Mouse Signaling threshold-regulating transmembrane adapter 1 (Sit1), partial

Recombinant Mouse Signaling threshold-regulating transmembrane adapter 1 (Sit1), partial

  • 中文名稱：
    小鼠Sit1重組蛋白
  • 貨號：
    CSB-YP803995MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Sit1重組蛋白
  • 貨號：
    CSB-EP803995MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Sit1重組蛋白
  • 貨號：
    CSB-EP803995MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Sit1重組蛋白
  • 貨號：
    CSB-BP803995MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Sit1重組蛋白
  • 貨號：
    CSB-MP803995MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Sit1
  • Uniprot No.：
  • 別名：
    Sit1; Sit; Signaling threshold-regulating transmembrane adapter 1; SHP2-interacting transmembrane adapter protein; Suppression-inducing transmembrane adapter 1
  • 種屬：
    Mus musculus (Mouse)
  • Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Negatively regulates T-cell antigen receptor (TCR)-mediated signaling. Involved in positive selection of T-cells.
  • 基因功能參考文獻：
    1. SIT and LAX are important negative regulators of immune responses that functionally cooperate. PMID: 23307938
    2. SIT as an important modulator of TCR-mediated signaling that regulates T-cell activation, homeostasis and tolerance PMID: 21957439
    3. SIT is a critical negative regulator of T-cell receptor-mediated signaling PMID: 16107703
    4. SIT negatively regulates T cell homeostasis. PMID: 18209059
    5. SIT and T cell receptor-interacting molecule (TRIM) regulate cell fate of developing thymocytes and are essential regulators of central tolerance. PMID: 18941181

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  • 亞細胞定位：
    Cell membrane; Single-pass type III membrane protein.
  • 組織特異性：
    Expressed in thymus and spleen, with highest levels in immature thymocytes (at protein level).
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:54390

    UniGene: Mm.31775