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  4. Recombinant Mouse Sodium/potassium/calcium exchanger 4 (Slc24a4), partial

Recombinant Mouse Sodium/potassium/calcium exchanger 4 (Slc24a4), partial

  • 中文名稱：
    小鼠Slc24a4重組蛋白
  • 貨號：
    CSB-YP805587MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Slc24a4重組蛋白
  • 貨號：
    CSB-EP805587MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Slc24a4重組蛋白
  • 貨號：
    CSB-EP805587MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Slc24a4重組蛋白
  • 貨號：
    CSB-BP805587MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Slc24a4重組蛋白
  • 貨號：
    CSB-MP805587MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc24a4
  • Uniprot No.：
  • 別名：
    Slc24a4; Nckx4; Sodium/potassium/calcium exchanger 4; Na(+)/K(+)/Ca(2+)-exchange protein 4; Solute carrier family 24 member 4
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis.
  • 基因功能參考文獻：
    1. Thus, despite its relative abundance in the lens, Nckx4 does not appear to have an indispensable role in the maintenance of lens clarity. PMID: 29128492
    2. The authors show that NCKX4 shapes the cone photoresponse together with the cone-specific NCKX2: NCKX4 acts early to limit response amplitude, while NCKX2 acts late to further accelerate response recovery. The regulation of Ca(2+) by NCKX4 in cones is a novel mechanism that supports their ability to function as daytime photoreceptors and promotes their survival. PMID: 28650316
    3. immunostaining of the apical plasma membranes of fluorotic ameloblasts was strongly reduced or absent suggesting that trafficking of NCKX4 to the apical membrane was strongly reduced PMID: 27752731
    4. olfactory sensory neurons in NCKX4(-/-);CNGB1(DeltaCaM) mice displayed markedly reduced electro-olfactogram amplitude accompanied by alterations in other response attributes PMID: 28053034
    5. pigment cells express robust, functional NCKX4 activity PMID: 27093457
    6. These findings highlight an essential, and to our knowledge previously unknown, role for Ca(2+) signaling in the MC4R pathway that leads to satiety, and a novel non-redundant role for NCKX4-mediated Ca(2+) extrusion in controlling MC4R signaling PMID: 25096581
    7. NCKX4 activity is stimulated by ATP through activation of the P2Y receptor signalling pathway. PMID: 24224486
    8. NCKX4 might be an important regulator of Ca(2+) transport during amelogenesis. PMID: 22677781
    9. These findings support a key role for SLC24A4 in calcium transport during enamel formation. PMID: 23375655
    10. These results establish the role of NCKX4 in shaping olfactory responses and suggest that rapid response termination and proper adaptation of peripheral sensory receptor cells tune the sensory system for optimal perception. PMID: 22057188

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  • 亞細胞定位：
    Cytoplasm. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
  • 組織特異性：
    Expressed in late secretory-stage and maturation-stage ameloblasts, with significantly increased expression during the late stages of amelogenesis (at protein level). Widely expressed in most regions of the brain, including hippocampus, neocortex, thalamu
  • 數據庫鏈接：

    KEGG: mmu:238384

    UniGene: Mm.312448