Recombinant Rat 72 kDa type IV collagenase (Mmp2)
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中文名稱:大鼠Mmp2重組蛋白
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貨號:CSB-YP014666RA
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規(guī)格:¥1836
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圖片:
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其他:
產(chǎn)品詳情
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純度:Greater than 90% as determined by SDS-PAGE.
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基因名:
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Uniprot No.:
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別名:Mmp2; 72 kDa type IV collagenase; EC 3.4.24.24; 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2) [Cleaved into: PEX]
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種屬:Rattus norvegicus (Rat)
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蛋白長度:Full Length of Mature Protein
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來源:Yeast
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分子量:64.1kDa
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表達區(qū)域:110-662aa
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氨基酸序列YNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSNDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKMDPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. -
蛋白標(biāo)簽:N-terminal 6xHis-tagged
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產(chǎn)品提供形式:Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
緩沖液:If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose. -
儲存條件:Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質(zhì)期:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項:Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet & COA:Please contact us to get it.
相關(guān)產(chǎn)品
靶點詳情
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功能:Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues.; PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta3 on the surface of blood vessels.
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基因功能參考文獻:
- MMP-2-activated near-infrared fluorescence signal correlates with the severity of intimal thickening in arteriovenous fistula created for hemodialysis access. PMID: 30061060
- Suggest roles for MMP2/9 in the morphological evolution of vasculature in surgical fl aps. PMID: 27902934
- MMP2 expression mediates the development of cyclophosphamide-induced cardiomyopathy. PMID: 29504102
- Data show that retinoic acid receptor alpha (RARalpha) improved the renal function and attenuated the progression of glomerulosclerosis (GS) that was associated with the over-expression of matrix metalloproteinases MMP2 and MMP9. PMID: 28645189
- Secretagogin-dependent MMP2 release from neurons regulates neuroblast migration. PMID: 28223495
- High MMP2 expression is associated with seizures. PMID: 28501723
- Studied effect of all-trans retinoic acid (ATRA) on matrix metalloproteinase 2 (MMP-2), and MMP-9 expression/ activity, and rat bone marrow-derived mesenchymal stem cell migration. MMP-2/-9 expression levels were higher in ATRA-treated MSCs; MMP-2/-9 activity was enhanced with increasing doses. Scratch test showed ATRA promoted cell migration of MSCs. PMID: 28488074
- immediate postnatal nutritional programming induces increases in circulating and aortic MMP-2 activity with parallel aortic wall alterations, such as decreased elastin integrity and enhanced thickening PMID: 26547079
- This study showed that in addition to the general reduction in placental and fetal growth during uteroplacental ischemia, localized angiogenic imbalance and diminished MMP-2 and MMP-9 could cause further decrease in placental and myoendometrial vascularization and placental and fetal growth in distal vs proximal uterus in hypertensive pregnant rats. PMID: 28912068
- Thus, similar to pharmaceutical ACE inhibitor captopril the dipeptide IW may effectively inhibit ACE activity and prevent the age and hypertension associated rise of aortic stiffness. PMID: 27239047
- Hyperglycemic animals showed an increased area of collagen fibers in the prostate, which was composed both types of collagens. MMP-2 activity was significantly reduced in the hyperglycemic animals, while MMP-9 activity was very low and showed no alteration. PMID: 28989027
- High MMP2 expression is associated with uraemic vascular calcifications. PMID: 26333546
- High mmp2 expression is associated with Retinitis Pigmentosa. PMID: 27893855
- MMP-2 mediates sarcomere degeneration in oncostatin M-induced cardiomyocyte dedifferentiation. PMID: 27199120
- conclusion, this study revealed a novel function of canstatin for inducing cell migration of adult rat cardiac fibroblasts at least in part by ERK phosphorylation through MMP-2 secretion, possibly via actin cytoskeletal change. PMID: 28003226
- The increase in nuclear MMP-2 activity seen during stunning injury here, indicates yet unknown biological actions, other than lamin proteolysis, which may require more severe ischemia to effect. PMID: 27079252
- The present study investigated rat models of Feeney's freefall-induced brain injury combined with Achilles tendon rupture-induced heterotopic ossification. It analyzed the altered curves of MMP-9, MMP-2 and tissue inhibitor of metalloproteinase-1 (TIMP-1) in addition to the curves of gene expression. PMID: 28259914
- indicated that fibulin3 may reduce the levels of MMP2 and 9 and oxidative stress in hypertensive vascular remodeling. PMID: 27035767
- a role of miR-29b-3p in vascular calcification involves targeting MMP2. PMID: 28164126
- the endothelium under ANGII stimulation acts as a novel and key activator of latent pro-MT1MMP and pro-MMP2 in smooth muscle cells of rat aorta PMID: 26598508
- the D/P Cr ratio was correlated with effluent levels of TN-C (rho = 0.57, p < 0.001) and MMP-2 (rho = 0.73, p < 0.001). We suggest that TN-C in the effluents may be a diagnostic marker for peritoneal deterioration with EMT-like change PMID: 26770971
- cardiomyocytes in 2D culture synthesize matrix metalloproteinases MMP-2 and MMP-9 PMID: 26567576
- Report cross-talk between macrophages, smooth muscle cells, and endothelial cells in response to cigarette smoke alters MMP2/9 levels. PMID: 26318311
- Nuclear factor kappaB inhibitor pyrrolidine dithiocarbamate modulates myocardial MMP-2 expression and ameliorates cardiac remodelling in renovascular hypertension. PMID: 25816715
- High phosphate/calcium induces vascular smooth muscle cell calcification and differentiation to an osteochondrogenic phenotype with an associated increase in MMP-2 expression. PMID: 25987498
- Angiotensin II regulates MMP-2, MMP-9, and TIMP-1 expression and affects collagen deposition. PMID: 25867313
- Rosiglitazone attenuates the increased MMP2/9 activity induced by cigarette smoke. PMID: 25897215
- High matrix Methaloproteinase 2 expression is associated with oral cancer. PMID: 25605162
- Ischemia/reperfusion-activated MMP-2 leads to the degradation of cardiac MLCK. PMID: 25451385
- MMP-2 degraded Titin fragment in serum is related to induction of skeletal muscle atrophy. PMID: 25077715
- The increased activationof MMP2 in spontaneously hypertensive rat may also lead to endothelial hypermeability, apoptosis and vascular rarefaction. PMID: 23481598
- Effects of maternal diabetes on male offspring: high cell proliferation and increased activity of MMP-2 in the ventral prostate. PMID: 24988912
- MMP2 seems to contribute to early brain elevation of IL-1beta after transient ischemia PMID: 25108165
- Our results, taken together, demonstrated that MMP-2 and MMP-9 were involved in the development of H2S-induced acute lung injury and dexamethaxone exerted protective effects by alleviating the expression of MMP-2 and MMP-9. PMID: 24722316
- MMP-2 may have a functionally significant role in the etiology of degenerative disc disease PMID: 23621950
- The data suggest that Matrix metalloproteinases, and more specifically MMP-2, influence the growth of developing afferent neurites in the mammalian inner ear in vivo. PMID: 24935409
- Results suggest that MMP-2 and MMP-9 may play a significant role in blood-brain barrier disruption after alcohol abuse. PMID: 24966898
- Aortic dissection is initiated by MMP-2 overexpression as a result of increased NA release from sympathetic nervous endings in response to Ang II. PMID: 24194850
- intracellular inhibition of MMP-2 in cardiomyocytes increases contractility of aerobically perfused myocytes PMID: 24769238
- these results described a novel mechanism in atherosclerosis through PDGF-BB signaling in VSMC, in which MMP-2 expression is induced via extracellular signal-regulated kinases and p38 mitogen-activated protein kinase phosphorylation, as well as ROCK PMID: 24792035
- Brain MMMP-2 activity levels are increased following withdrawal from self-administered cocaine. PMID: 25326689
- MMP-2 -1306 C/T was shown to be involved in the pathogenesis of prostate cancer in a Turkish population. PMID: 25539555
- Demonstrate that ANGII regulates pro-MMP-2 protein expression via cell-specific pathways in rat aorta. PMID: 24907869
- In a rat mammary neoplasm model matrix metalloproteinase 2 localization, was localized to cancer cells and fibroblasts than in the stroma. PMID: 25343559
- The levels of active MMP-2 are downregulated in peripheral nerve during diabetes and with treatment withminocycline. PMID: 25158309
- The location of Mmp2 and activity can be detected by means of in situ zymography and confocal microcopy, and this methodology may provide a useful tool in studies on the role of gelatinases in tooth development, maturation and in pathological conditions. PMID: 22897943
- LA modulated increased MMP-2 and MMP-9 activities and decreased TIMP-1 and TIMP-2 levels during renal I-R. PMID: 24160412
- This study demonistrated that mmp2 throughout hippocampus at all ages but expression levels were highest during the first postnatal week. PMID: 24114974
- I/R injury in steatotic livers resulted in significant increases in expression of YKL-40 (9 fold), and activation of MMP-2 (15 fold)/MMP-9 (12 fold). PMID: 24380732
- Data indicate that mechanical stretch induces MMP-2 production in vascular smooth muscle cells (VSMC) via activation of Akt pathway, that is mediated by activation of PDGFR-beta signaling pathways. PMID: 23950935
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亞細(xì)胞定位:Secreted, extracellular space, extracellular matrix. Membrane. Nucleus.
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蛋白家族:Peptidase M10A family
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